Synthesis and characterization of poly(4-alkyl-4-methyl-2-azetidinone)s

Fournier, Martin; Prud’homme, Robert E.

doi:10.1002/(sici)1099-0518(19990315)37:6<761::aid-pola11>3.0.co;2-x

Cited by 4 publications

(1 citation statement)

References 14 publications

(31 reference statements)

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“…Recently, Kumar et al performed an alkyne/azide click chemistry on PA-3 bearing azide functions previously synthesized by anionic polymerization of acrylamide initiated by sodium azide . The synthesis of polyamide-3 was also achieved through polycondensation of β-alanine and its derivatives , or by ring-opening polymerization of substituted β-lactams − or unsubtituted β-propiolactam with an enzymatic or an anionic approach . However, and depending on the polymerization method, some limitations are observed, such as a low monomer conversion, low molar masses, long reaction time, or the use of toxic solvent.…”

Section: Introductionmentioning

confidence: 99%

Solvent-Free Anionic Polymerization of Acrylamide: A Mechanistic Study for the Rapid and Controlled Synthesis of Polyamide-3

et al. 2016

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Mechanistic insights into bulk hydrogen-transfer polymerization of acrylamide initiated by t-BuONa are proposed in this study where attention is particularly given to the initiation and propagation steps. This anionic polymerization methodology led to the synthesis of polyamide-3 with controlled molar masses. NMR, SEC, and MALDI-ToF characterizations are supporting the chemical structures and the macromolecular dimensions of polyamide-3. The polymerization is completed in a few minutes depending on the targeted molar mass as confirmed by a complementary temperature vs time study. DSC and TGA measurements enabled the determination of the glass transition and degradation temperatures at 88 and 357 °C, respectively. Side reactions such as branching, transfer to monomer, and formation of polyacrylamide units were shown to occur and depend on the amount of base added. The formation of imide groups is also observed due to the formation of ammonia in the polymerization medium.

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Section: Introductionmentioning

confidence: 99%

Solvent-Free Anionic Polymerization of Acrylamide: A Mechanistic Study for the Rapid and Controlled Synthesis of Polyamide-3

et al. 2016

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Synthesis, characterization, and in vitro drug release study of 3‐arm poly‐β‐alanine

Kumar

Adhikary

Tungala

et al. 2015

J of Applied Polymer Sci

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Synthesis of three arms star-shaped poly-b-alanine (3-b-ala) based on tri(prop-2-yn-1-yl) benzene-1,3,5-tricarboxylate (TBT) and azido terminated poly-b-alanine (N 3 -P-ala) was performed using click reaction. TBT was synthesized by nucleophilic substitution reaction between propargyl alcohol and 1,3,5-benzenetricarbonyltrichloride. For the first time, N 3 -P-ala was synthesized through anionic polymerization of acrylamide using sodium azide as an initiator. TBT was characterized by FT-IR and 1 HNMR. N 3 -p-ala was characterized by FT-IR, GPC, and 1 HNMR and 3-b-ala was characterized by FT-IR, GPC, 1 HNMR, TGA, and XRD. The synthesized 3-b-ala was used for drug loading and releasing studies. Polymer loaded drug (3-b-ala-D) hybrid was used in in vitro studies of drug (Diclofenac sodium) release in phosphate buffer solution (PBS) at 37 6 0.5 C and pH 7.4. The drug loading and releasing studies were analyzed by UV-visible spectrophotometer. 3-b-ala-D was examined by AFM to analyze the surface morphology and roughness.

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Direct Poly(β-alanine) Synthesis via Polycondensation in Ionic Liquids

et al. 2012

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Poly(β-alanine) was successfully synthesized by an alternative method, which is the direct polyamidation of β-alanine in ionic liquids with triphenylphosphite as a condensing agent. It was found that 1,3-dimethylimidazolium dimethylphosphate was the most suitable reaction medium, in which a number-average degree of polymerization up to 49.5 was obtained. It was shown that the method is also applicable to the direct synthesis of polypeptides, for example, poly(l-valine) and poly(l-isoleucine).

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Synthesis and characterization of poly(4-alkyl-4-methyl-2-azetidinone)s

Cited by 4 publications

References 14 publications

Solvent-Free Anionic Polymerization of Acrylamide: A Mechanistic Study for the Rapid and Controlled Synthesis of Polyamide-3

Solvent-Free Anionic Polymerization of Acrylamide: A Mechanistic Study for the Rapid and Controlled Synthesis of Polyamide-3

Synthesis, characterization, and in vitro drug release study of 3‐arm poly‐β‐alanine

Direct Poly(β-alanine) Synthesis via Polycondensation in Ionic Liquids

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