Synthesis and characterization of platinum–sterol hydrazone complexes with biological activity against Leishmania (L.) mexicana

Synthesis and antileishmanial activity of novel pyridinium-hydrazone derivatives

“…These compounds comprising a diverse group of chemical structures have been reported as antileishmanial agents. Most of them include nitrogen heterocycle rings such as quinolines 9 , quinazolines 10 , acridines 11 , pyrimidines 12 , pyrazols 13 , pyridines 8 , benzothiazoles 14 , imidazoles 15 , thiadiazoles 16 and include functional structures such as alkyl phospholipids 17 , ether phospholipids 18 , chalcones 19 , amidines 20 , oximes 21 , amidoxime 22 , hydrazones 23 and hydrazides 24,25 . On the other hand, a number of quaternized amine derivatives such as thiadiazolium-phenylamine 26,27 , arylisoquinolinium 28 , imidazo-pyridinium 29 , alkylammonium-phenothiazines 30 , indolo-quinolinium 31 and naphthalimide-amonnium 32 were previously reported to exert antiprotozoal properties.…”

Pharmacologically potentials of hydrazonone containing compounds: a promising scaffold

“…Promastigotes of Leishmania (L) Mexicana were treated for 48 h with 10 μM of the sterol hydrazones Hpy1 or Hpy2 alone or coordinated to Pt. Hpy1 produced higher leishmanistatic activity than Hpy2 (39% growth inhibition vs. 16%), which significantly increased (71%) when the complex trans-(Pt (Hpy1) 2 (Cl) 2 ) was used (Visbal et al, 2008). .…”

Synthesis and characterization of some Chromium(III) complexes of dibasic tridentate hydrazone schiff base ligands

“…The coordination chemistry of aroylhydrazones has received much impetus due to its remarkable anticancer, antimicrobial, antiviral, vasodilator, analgesic and anti inflammatory properties exhibited by these compounds which can be related to their metal complexing abilities [1][2][3][4][5][6][7][8][9]. This paper presents the synthesis and characterization of four new tridentate Schiff base ligands, N-(2-hydroxy-1-naphthaldehyde)--(4-nitrobenzoyl)hydrazone (HNNH = H2L 1 ),N-(2-hydroxy-4-methoxybenzaldehyde)--(2-furoyl) hydrazone (HMFH = H2L 2 ), N-(2-hydroxyacetophenone)--(2-theonyl) hydrazone (HATH = H2L…”