Synthesis and Characterization of Photo-Cross-Linked Networks Based on l-Lactide/Serine Copolymers

Abstract

New lactide-based polydepsipeptide polymer networks and cross-linked beads have been prepared by UV photopolymerization of acrylated poly(L-lactic acid-co-glycolic acid-co-L-serine) [PLA-(Glc-Ser)]. These materials have been developed for use as polymer scaffolds in tissue engineering, cell encapsulation, and injectable drug delivery, which have ligand-immobilizable and biodegradable characteristics. The acrylated PLA(Glc-Ser) cross-linked polymer networks obtained were glassy and transparent, and the gel content was approximately 90%. The networks showed relatively low swelling in water, due to their cross-linked nature, but are easily swelling in chloroform and in dimethyl sulfoxide. The acrylate polymers on copolymerization with 2-hydroxyethyl methacrylate (HEMA) resulted in crosslinked networks [PLA(Glc-Ser)/HEMA], which were swelling in water and in DMSO showing the potential of the polymer in hydrogel applications. The modified PLA(Glc-Ser) beads prepared by UV-initiated suspension polymerization were characterized by optical microscopy and FTIR. These degradable networks and beads should be useful as polymer scaffolds for biomaterial applications. † Creative and fundamental R&D program for SME's. ‡ Japan Small Business Corporation.

Novel Aliphatic Polyesters Based on Functional Cyclic (Di)Esters

“…Copolymers containing thiol residues suffer from severe degradation. 2,5-Morpholinedione derivatives in which R 2 is a hydrogen atom (7a-10a) [25][26][27][28][29][30][31][32] have also been reported to undergo both homoand copolymerization.…”

Electrospun nanofibers of a degradable poly(ester amide). Scaffolds loaded with antimicrobial agents

“…Specifically, different poly(ester amide)s have been developed for biomedical applications such as drug delivery systems (e.g. in the form of microspheres [1][2][3][4][5][6][7][8] or coatings [9][10][11][12][13]), hydrogels [14,15], smart materials [16], tissue engineering [17][18][19][20] and gene carriers [21].…”

Synthesis and characterization of inexpensive 3-Nɛ-benzyloxycarbonyl-L-lysyl-morpholine-2,5-dione

“…Morpholine-2,5-dione derivatives can open-polymerize or open-copolymerize by initiation or catalysis with other cyclic compounds such as lactide (LA) [1][2][3][4][5][6][7][8][9], e-Caprolactone (CL) [10][11][12][13], and the homopolymers and copolymers have some reaction-active groups such as amido (−NH 2 ), carboxyl (−COOH), hydroxyl (−OH), mercapto (−SH), and so on [14]. These polymers or copolymers have both excellent biocompatibility and biodegradability, so they can be widely used in the field of tissue engineering and controlled-drug-release system.…”