Synthesis and characterization of pH and temperature double-sensitive nanocomposite hydrogels consisting of poly(dimethylaminoethyl methacrylate) and clay

Chen, Yi; Xu, Weijian; Xiong, Yan; Peng, Chang; Liu, Wenyong; Zeng, Guangsheng; Peng, Yue

doi:10.1557/jmr.2013.82

Cited by 26 publications

(19 citation statements)

References 27 publications

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“…An absorption peak around 1635 cm −1 was detected due to the bend vibration of CC groups which shows that the considerable CC groups remain in PDMAEMA Hgs‐11 sample. Chen and coworkers reported that the existed CC groups is indicative of the presence of incomplete reacted monomer . Reversely, the intensity of the absorption was low in the spectra of Hgs‐1 and Hgs‐6 samples, indicating the nearly complete reaction of monomer in the hydrogels prepared at low gel preparation concentration.…”

Section: Resultsmentioning

confidence: 99%

Influence of gel preparation concentration on statistical mechanics of poly(dialkylaminoethyl methacrylate) gels on the basis of scaling concept: Toward tunable elasticity and thermomechanical parameters

Tanc

Orakdöğen

2019

J of Applied Polymer Sci

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In order to evaluate the scaling parameters of weakly cationic crosslinked network structures, poly(dialkylaminoethyl methacrylate)‐based hydrogels were synthesized via free‐radical crosslinking in aqueous solution varying systematically concentration of pregel solution. Based on the gel‐preparation concentration, variation in structural properties, effective crosslinking density, average molecular weight of polymer chains, and thermodynamic parameters from combined swelling and elasticity results were discussed using the scaling theory to predict various exponent identities. The concentration dependence of compressive elastic modulus as‐prepared state was described by a power‐law relationship G0≈ν20m with the exponent of m = 3.55 indicating the importance of the trapped entanglements. Two structural characteristics, the network chain length N and the average molecular weight of polymer chains have inverse dependence on the gel‐preparation concentration in the matrix, while the compressive moduli and effective crosslinking density show completely direct dependence. Experimentally determined N values of PDMAEMA hydrogels first decrease with increasing ν20 up to 0.2972 and the dependence of N on the gel‐preparation concentration gives the relation N≈X−1ν20n with a scaling parameter n = −1.80, which coincides with the prediction of scaling theory. Acceptable agreement was found between the estimate of crosslink density fluctuations deduced from mechanical measurements and the results derived from independent swelling observations. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48350.

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Section: Resultsmentioning

confidence: 99%

Influence of gel preparation concentration on statistical mechanics of poly(dialkylaminoethyl methacrylate) gels on the basis of scaling concept: Toward tunable elasticity and thermomechanical parameters

Tanc

Orakdöğen

2019

J of Applied Polymer Sci

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“…At low pH values, the protonation keeps polymer chains hydrophilic even when the hydrogen bonding is destroyed at high temperatures. However, at pH values higher than p K a , the deprotonation results in co‐occurrence of both hydrogen bonding and hydrophobic interactions where the latter predominates. In other words, in basic solution, the PDMAEMA chains quickly collapse due to the powerful hydrophobic interactions and less thermal energy is needed for phase transition.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and investigation of dual pH‐ and temperature‐responsive behaviour of poly[2‐(dimethylamino)ethyl methacrylate]‐grafted gold nanoparticles

Mohammadi

Salami‐Kalajahi

Roghani‐Mamaqani

et al. 2017

Applied Organom Chemis

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Gold nanoparticles (AuNPs) were synthesized by reduction of chloroauric acid (HAuCl4) aqueous solution with hydrazine monohydrate. The AuNPs were immediately treated with cysteamine to obtain amine‐functionalized nanoparticles (Au‐NH2). The reaction of Au‐NH2 with epichlorohydrin and subsequent treatment with sodium hydroxide gave epoxidized AuNPs (Au‐EP). Then, thiol‐capped AuNPs (Au‐SH) were synthesized by reaction of Au‐EP with cysteamine. A ‘grafting to’ approach was utilized to graft bromine‐terminated poly(N,N′‐dimethylaminoethyl methacrylate), synthesized via aqueous atom transfer radical polymerization, with various molecular weights (6280, 25 800, 64 200 and 87 600 g mol−1) onto Au‐SH to obtain Au‐P1, Au‐P2, Au‐P3 and Au‐P4 samples, respectively. All samples were exposed to temperature and pH variations, and Z‐average diameter was monitored using dynamic light scattering. According to the results, polymer‐grafted nanoparticles collapsed at lower temperatures with increasing solution pH for all molecular weight ranges due to deprotonation of tertiary amine groups. However, higher molecular weight polymers were more sensitive to pH variation especially in alkaline media. Also, a high degree of agglomeration was observed for Au‐P4 nanoparticles in alkaline media on increasing the temperature to 55 and 65 °C.

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“…This structure favored the release of the content by electrical stimulation which changed the redox state of the polypyrrole (55). The use of copolymers in the preparation of the composites was recurrent in the studies found (11, 29,52,55,58,60,61). The copolymers associate different polymer units, achieving synergistic effects for certain properties or associating different characteristics.…”

Section: Polymersmentioning

confidence: 99%

“…Therefore, the physically crosslinked hydrogel by Laponite proved suitable for biological applications given its volume phase transition temperature at around 40°C approaching that of the human body, and also due to the ability to reversible stimuliresponsiveness (60). Moreover, other approaches involved double-responsive composites, whose release was modulated by both pH and temperature (29,58,89).…”

Section: Modified Drug Release Systems: Improvements Derived From Orgmentioning

confidence: 99%

Clay and Polymer-Based Composites Applied to Drug Release: A Scientific and Technological Prospection

Meirelles

Raffin

2017

J Pharm Pharm Sci

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-There has been a growing trend in recent years for the development of hybrid materials, called composites, based on clay and polymers, whose innovative properties render them attractive for drug release. The objective of this manuscript was to conduct a review of original articles on this topic published over the last decade and of the body of patents related to these carriers. A scientific prospection was carried out spanning the period from 2005 to 2015 on the Web of Science database. The technological prospection encompassed the United States Patent and Trademark Office, the European Patent Office, the World International Patent Office and the National Institute of Industrial Property databases, filtering patents with the code A61K. The survey revealed a rise in the number of publications over the past decade, confirming the potential of these hybrids for use in pharmaceutical technology. Through interaction between polymer and clay, the mechanical and thermal properties of composites are enhanced, promoting stable, controlled drugs release in biological media. The most cited clays analyzed in the articles was montmorillonite, owing to its high surface area and capacity for ion exchange. The polymeric part is commonly obtained by copolymerization, particularly using acrylate derivatives. The hybrid materials are obtained mainly in particulate form on a nanometric scale, attaining a modified release profile often sensitive to stimuli in the media. A low number of patents related to the topic were found. The World International Patent Office had the highest number of lodged patents, while Japan was the country which published the most patents. A need to broaden the application of this technology to include more therapeutic classes was identified. Moreover, the absence of regulation of nanomaterials might explain the disparity between scientific and technological output.

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Synthesis and characterization of pH and temperature double-sensitive nanocomposite hydrogels consisting of poly(dimethylaminoethyl methacrylate) and clay

Abstract: Abstract

Cited by 26 publications

References 27 publications

Influence of gel preparation concentration on statistical mechanics of poly(dialkylaminoethyl methacrylate) gels on the basis of scaling concept: Toward tunable elasticity and thermomechanical parameters

Influence of gel preparation concentration on statistical mechanics of poly(dialkylaminoethyl methacrylate) gels on the basis of scaling concept: Toward tunable elasticity and thermomechanical parameters

Synthesis and investigation of dual pH‐ and temperature‐responsive behaviour of poly[2‐(dimethylamino)ethyl methacrylate]‐grafted gold nanoparticles

Clay and Polymer-Based Composites Applied to Drug Release: A Scientific and Technological Prospection

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