Synthesis and characterization of p (N-isopropylacrylamide)  hydrogels with tunable swelling behavior using different crosslinkers

Kubilay, Şenol; Selçuk, Kadir; Sariaydin, Dursun

doi:10.15671/hjbc.719698

Cited by 2 publications

(1 citation statement)

References 45 publications

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“…In general, acrylamide-based compounds are well known for their absorptive and medicinal properties. In line with our research interest in AAm based materials, [17][18][19][20][21][22] in this article we report the copolymerization of NIPAAm with AAm. The present study aims to develop N-isopropyl acrylamide/acrylamide; (NI-PAAm/AAm) based hydrogels with pH and temperature sensitivities and higher swelling properties.…”

Section: Introductionsupporting

confidence: 68%

Smart Hydrogels: Preparation, Characterization, and Determination of Transition Points of Crosslinked N-Isopropyl Acrylamide/Acrylamide/Carboxylic Acids Polymers

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2021

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Smart hydrogels (SH) were prepared by thermal free radical polymerization of N-isopropyl acrylamide (NIPAAm), acrylamide (AAm) with acrylic acid (A) or maleic acid (M), and N, N′-methylene bisacrylamide. Spectroscopic and thermal characterizations of SHs were performed using FTIR, TGA, and DSC. To determine the effects of SHs on swelling characteristics, swelling studies were performed in different solvents, solutions, temperatures, pHs, and ionic strengths. In addition, cycle equilibrium swelling studies were carried out at different temperatures and pHs. The temperature and pH transition points of SHs are calculated using a sigmoidal equation. The pH transition points were calculated as 5.2 and 4.2 for SH-M and SH-A, respectively. The NIPAAm/AAm hydrogel exhibits a critical solution temperature (LCST) of 28.35 °C, while the SH-A and SH-M hydrogels exhibit the LCST of 34.215 °C and 28.798 °C, respectively, and the LCST of SH-A is close to the body. temperature. Commercial (CHSA) and blood human serum albumin (BHSA) were used to find the adsorption properties of biopolymers on SHs. SH-M was the most efficient SH, adsorbing 49% of CHSA while absorbing 16% of BHSA. In conclusion, the sigmoidal equation or Gaussian approach can be a useful tool for chemists, chemical engineers, polymer and plastics scientists to find the transition points of smart hydrogels.

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Section: Introductionsupporting

confidence: 68%

Smart Hydrogels: Preparation, Characterization, and Determination of Transition Points of Crosslinked N-Isopropyl Acrylamide/Acrylamide/Carboxylic Acids Polymers

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2021

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Effect of using high molecular weight crosslinker on the physical properties of super porous hydrogel composite

Safa Mohammed Nser,

Athmar Dhahir Habeeb Al-Shohani,

Alaa Abuawad

2023

AJPS

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Superporous hydrogel composite is widely utilized and investigated as a gastro retentive drug delivery system. Materials used in Superporous hydrogel formulation have a profound effect on its properties’, N-methylene bisacrylamide is the crosslinker of choice for the preparation of SPH. The purpose of this study is to determine if using a new high molecular weight crosslinker such as polyethylene glycol diacrylate will affect the physical characteristics of SPH and drug release behavior. For the preparation of super porous hydrogel polyvinyl alcohol, acrylamide, polyethylene glycol diacrylate 700, N, N-Methylene bisacrylamide, sodium bicarbonate, and tween 20 were used. Trifluoperazine HCl was used as a model drug. The buoyancy, porosity, density, drug release, drug content, swelling ratio, and swelling time were studied and compared. All the physical characteristics and medication release profiles were impacted by changing the formulation parameters. The formula with the best physical qualities had 300 µl of acrylamide (40 percent w/v), 20 mg of polyvinyl alcohol, 200 µl of Tween 20 (v/v), 5 µl of polyethylene glycol diacrylate 700, 45 µl ammonium persulfate, 45 µl TEMED and 50 mg of sodium bicarbonate. Around 80% of the drug was released over the course of 12 hours according to zero order kinetics. By modifying the formulation parameters using polyethylene glycol diacrylate, Superporous hydrogel was successfully manufactured and has the best properties to be employed as a gastro retentive drug delivery system.

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Synthesis and characterization of p (N-isopropylacrylamide) hydrogels with tunable swelling behavior using different crosslinkers

Cited by 2 publications

References 45 publications

Smart Hydrogels: Preparation, Characterization, and Determination of Transition Points of Crosslinked N-Isopropyl Acrylamide/Acrylamide/Carboxylic Acids Polymers

Smart Hydrogels: Preparation, Characterization, and Determination of Transition Points of Crosslinked N-Isopropyl Acrylamide/Acrylamide/Carboxylic Acids Polymers

Effect of using high molecular weight crosslinker on the physical properties of super porous hydrogel composite

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