Synthesis and characterization of novel flavonoid derivatives via sequential phosphorylation of quercetin

Abstract

Flavonoids constitute a large family of plant-derived polyphenolic compounds that are found in fruits, vegetables, spices, wines and juices 1. Examples of flavonoids include quercetin, fisetin, luteolin, apeginin, myricetin and many others. Previous studies have shown that these compounds exhibit an array of biological effects that are beneficial to humans, including antiviral, antioxidative, anti-inflammatory and anticarcinogenic. The solubility of these polyphenolic compounds can be increased through the modification of the chemical structure, which may improve oral bioavailability 2. As a result, considerable efforts have been directed towards the development of novel, highly soluble conjugates having clinical profiles that are similar or even superior to those exhibited by the parent molecules in vitro. These include synthetic esters, acyl

Antimicrobial Activity of a New Class of Phosphorylated and Modified Flavonoids

“…10 Osonga et al have also demonstrated the solubility of quercetin via sequential phosphorylation. 11…”

“…11 In this study, both quercetin and apigenin were modified with benzyl phosphite following the procedure by Osonga et al. 11 The synthesis of QSA was followed by using the previously reported literature. 28 The addition of the sulfonate group helps to increase the solubility as well as increasing the acidity of the compound.…”

Flavonoid-derived anisotropic silver nanoparticles inhibit growth and change the expression of virulence genes in Escherichia coli SM10

“…[23][24][25] However, its biological activities have been limited by poor solubility in aqueous solvents. We have reported the synthesis of phosphorylated quercetin derivatives 26 with signicantly enhanced solubility in water than the parent quercetin. [27][28][29] The anisotropic AgNPs have varying bactericidal effects when prepared in various shapes and sizes.…”

Synthesis, characterization and antifungal activities of eco-friendly palladium nanoparticles

“…The sequential synthesis was undertaken to develop modied hydroxyl groups, which produced modied avonoids derivatives, quercetin diphosphate (5,4 0 -QDP) which was synthesized and characterized as reported in our previous work. 26…”

“…Synthesis of palladium nanoparticles from QDP and palladium(II) ions.Step asynthesis of QDP from quercetin,26 1quercetin, 2 -QDP, 3aunfavorable surface complex state, 4afavorable surface complex state, 3bunfavorable oxidation-reduction state, and 4bfavorable oxidation-reduction state. Green-favorable state while red-unfavorable but viable state.…”