Synthesis and characterization of novel tamarind gum and rice bran oil-based emulgels for the ocular delivery of antibiotics

Rawooth, Madhusmita; Qureshi, Dilshad; Hoque, Monjurul; Prasad, M P; Mohanty, Biswaranjan; Alam, Mohammad Asif; Anis, Arfat; Sarkar, Preetam; Pal, Kunal

doi:10.1016/j.ijbiomac.2020.07.231

Cited by 18 publications

(5 citation statements)

References 44 publications

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“…This suggested the fact that the rate of diffusion of the drug was composition dependent. The diffusion rate of the drug from the polymeric composite film was controlled by the viscosity-building properties of TG [ 74 ]. The K value of F1D was similar to the K value of F3D and F4D ( p > 0.05).…”

Section: Resultsmentioning

confidence: 99%

“…Ciprofloxacin (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazine-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrate, CPH) is the most effective fluoroquinolone antibiotic against Gram-negative bacilli bacteria such as Escherichia coli, Salmonella spp., Shigella spp., and diplococci Neisseria spp. [ 45 , 74 ]. It was also found to be effective against some Gram-positive strains [ 76 ].…”

Section: Resultsmentioning

confidence: 99%

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Effect of Tamarind Gum on the Properties of Phase-Separated Poly(vinyl alcohol) Films

Rawooth

Habibullah²,

Qureshi

et al. 2022

Polymers

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The current study aims to evaluate the effect of tamarind gum (TG) on the optical, mechanical, and drug release potential of poly(vinyl alcohol) (PVA)-based films. This involves preparing PVA-TG composite films with different concentrations of TG through a simple solvent casting method. The addition of TG has enhanced the phase separation and aggregation of PVA within the films, and it becomes greater with the increase in TG concentration. Brightfield and polarized light micrographs have revealed that aggregation is favored by forming crystalline domains at the PVA-TG interface. The interconnected network of PVA-TG aggregates influenced the swelling and drying properties of the films. Using Peleg’s analysis, the mechanical behavior of films was determined by their stress relaxation profiles. The addition of TG has made no significant changes to the firmness and viscoelastic properties of films. However, long-durational relaxation times indicated that the interconnected network might break down in films with higher TG concentration, suggesting their brittleness. The controlled release of ciprofloxacin in HCl solution (0.5% (w/v)) appears to decrease with the increase in TG concentration. In fact, TG has inversely affected the impedance and altered the ionic conductivity within the films. This seems to have directly influenced the drug release from the films as the mechanism was found to be non-Fickian diffusion (based on Korsmeyer–Peepas and Peppas–Sahlin kinetic models). The antimicrobial study using Escherichia coli was carried out to evaluate the activity of the drug-loaded films. The study proves that TG can modulate the properties of PVA films and has the potential to fine-tune the controlled release of drugs from composite films.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Effect of Tamarind Gum on the Properties of Phase-Separated Poly(vinyl alcohol) Films

Rawooth

Habibullah²,

Qureshi

et al. 2022

Polymers

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“…Bigels were analysed on a Frontier Fourier transform infrared spectroscopy (FT‐IR) spectrum (Perkin Elmer, Inc., Waltham, MA, USA) coupled to an ATR accessory. The scanning was performed using a wavenumber range from 400 to 4000 cm −1 with a resolution of 4 cm −1 (Rawooth et al ., 2020).…”

Section: Methodsmentioning

confidence: 99%

Effect of the use of sweet potato or chayote tuber starch hydrogels on the physical properties of oleogel‐in‐hydrogel (bigels) systems

De Los Santos‐Trinidad,

Pérez‐Alonso,

Cruz‐Sosa

et al. 2023

Int J of Food Sci Tech

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SummaryBigel systems (BG) were formed through the combination of an oleogel (OG) formed with canola oil and beeswax (5% wt.), and a hydrogel (HG) formed with sweet potato (SP) or chayote tuber (CH) starch (10 % wt.), using three OG:HG ratios (30:70, 40:60, 50:50). All the BG were self‐standing, exhibiting uniform and well‐defined phase distribution of OG‐in‐HG, and oil binding capacities greater than 96%. Droplet size of BG was influenced by the OG:HG ratio, higher amount of OG produced smaller droplet sizes. The characterization of BG by FTIR and XRD showed structural configuration in BG is driven by physical and steric interactions by displaying distinctive characteristics of each individual phase and dismissing the formation of novel bonds. BG showed a pseudoplastic behaviour and was characterized as a weak gel, G′>G′′ at strains below 100% for BGSP and 50% for BGCH, with a shifting process (G′′>G′) at higher strains. Viscoelastic properties were influenced by the OG:HG ratio where BG at 50:50 exhibited lower strength and resistance to deformation. Textural parameters in BGSP were higher than BGCH, and influenced by the OG:HG ratio, indicating that the phase proportion in BG can modulate its structure and performance.

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“…The new combination in emulgels showed extended release of the two drugs which potentially improve resident time in ocular tissues, patient compliance, and adherence to treatment. Rawooth M, et al [48], developed tamarind gum (TG) and rice bran oil (RBO)-based emulgels of ciprofloxacin HCl and suggested a significantly lower release from the emulgel matrices. The emulgels were able to improve the corneal permeation of drug and thus could be explored to deliver drugs to the internal structures of the eye.…”

Section: Other Routesmentioning

confidence: 99%

Overview of Emulgel as Emergent Topical Delivery: Recent Applications and Advancement

Amgaonkar¹,

Kochar²,

Chandewar³

et al. 2021

JPRI

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Emulgel is an emerging delivery system with added advantages over other topical delivery systems which is proven to be boon for cosmetics and dermatology. Emulgels are emulsion which is converted to Gel, which will make it a non greasy and enhances patient compliance. The amalgamation of the two systems would be advantages in term of high drug loading capacity and low skin irritation, site specific targeting avoiding first-pass metabolism and increase in bioavailability. Work carried out by researchers proved that, Emulgel/ Nanoemulgel loaded with drugs has been found effective in many topical disorders and it is emerging as potential drug delivery system in area of dermatology. In the present review current research works that carried out on Emulgel and nano emulgels are discussed and also highlighted the recent applications of Emulgel in transdermal as well as dental, ocular, vaginal, and other delivery system.

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Synthesis and characterization of novel tamarind gum and rice bran oil-based emulgels for the ocular delivery of antibiotics

Cited by 18 publications

References 44 publications

Effect of Tamarind Gum on the Properties of Phase-Separated Poly(vinyl alcohol) Films

Effect of Tamarind Gum on the Properties of Phase-Separated Poly(vinyl alcohol) Films

Effect of the use of sweet potato or chayote tuber starch hydrogels on the physical properties of oleogel‐in‐hydrogel (bigels) systems

Overview of Emulgel as Emergent Topical Delivery: Recent Applications and Advancement

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