Synthesis and characterization of novel drug delivery nanoparticles based on polyzwitterionic copolymers

Kostova, Bistra; Kamenska, Elena; Momekov, Georgi; Rachev, Dimitar; Georgiev, Georgi V.; Balashev, Konstantin

doi:10.1016/j.eurpolymj.2012.12.003

Cited by 4 publications

(4 citation statements)

References 22 publications

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“…It was found that with increasing of MDMAPS, d decreased from 828 to 463 nm. Compared with the data obtained from our previous study (11), it could be concluded that the in situ inclusion of Ibu in the gel particles led to an increase of d, compared to d of the particles with the same copolymer composition but not loaded with Ibu. This relationship finds its confirmation from the analysis of SEM data and the release profiles of Ibu from CH2/Ibu, CH3/Ibu, and CH4/ Ibu.…”

Section: Characteristics Of Emulsifier-free Emulsion Copolymerizationcontrasting

confidence: 47%

“…It was established that the change of the initial monomer feed led to changes in the type and mechanism of EEC, as well as the shape, the average diameter and the morphology of the copolymer nanoparticles. Using this approach were obtained copolymer matrices with different compositions, structure and properties that release the drug depending on the therapeutic requirements (11).…”

Section: Introductionmentioning

confidence: 99%

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Design and Concept of Polyzwitterionic Copolymer Microgel Drug Delivery Systems In Situ Loaded with Non-steroidal Anti-inflammatory Ibuprofen

Kostova

Kamenska²,

Georgieva

et al. 2016

AAPS PharmSciTech

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Nowadays, the modern pharmaceutical investigations are directed toward obtaining of new polymer micro-and nano-sized drug delivery carriers. In this respect, the use of hydrogel carriers based on polyzwitterions (PZIs) is an opportunity in the preparation of polymer drug delivery systems with desired characteristics. This paper describes the synthesis and characterization of micro-structured p(VA-coDMAPS) systems with different compositions in situ loaded with Ibuprofen by emulsifier-free emulsion copolymerization (EEC) in water. The mean size of the prepared microparticles was measured by SEM and particles have been visualized by AFM. The inclusion of Ibuprofen in the polyzwitterionic copolymer microgel systems was established by using DSC. In vitro drug release experiments were carried out in order to estimate the ability of the obtained microgels to modify the release of water-insoluble Ibuprofen.

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Section: Characteristics Of Emulsifier-free Emulsion Copolymerizationcontrasting

confidence: 47%

Section: Introductionmentioning

confidence: 99%

Design and Concept of Polyzwitterionic Copolymer Microgel Drug Delivery Systems In Situ Loaded with Non-steroidal Anti-inflammatory Ibuprofen

Kostova

Kamenska²,

Georgieva

et al. 2016

AAPS PharmSciTech

Self Cite

View full text Add to dashboard Cite

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“…[3] In the synthesis of a polymer, chaingrowth polymerization reactions can be used to polymerize one or more type of monomer with the aid of an initiator. [4] The addition polymerization technique requires decomposition of an initiator to generate active species of free radicals, cations, or anions to polymerize the unsaturated monomers. [5] Free radical initiators (such as benzoyl peroxide, potassium persulfate (KPS), and 2,2'azobis(isobutyronitrile) (AIBN)) propagate the polymer chain with a carbon radical.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of N-vinylpyrrolidone/Acrylic acid nanoparticles for drug delivery: Method optimization

et al. 2018

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There are various approaches to deliver therapeutic agents to the preferred target. Polymeric nanoparticles were found to have pleasing suitability as a drug carrier. The goal of this research was to optimize the synthesis method to obtain the desirable %yield and particle properties of the new biocompatible polymer-based nanoparticles. The non-toxic polymer, N-vinyl pyrrolidone (NVP) and a widely used hydrophilic biocompatible acrylic acid (AA) monomer were used to form the drug nanocarriers. The synthesis method was optimized by changing the types of initiator (KPS or V50) and the monomers molar ratio (NVP:AA). It was found that by varying both the monomer molar ratio and the type of reaction initiator, did not have significant effect on the physicochemical characteristics of the nanocarriers. The FTIR spectra of all products exhibited the peaks of carboxylic acid, carbonyl, and tertiary amine functional group vibration. The particle size of the nanocarriers was in the range of 173.6 ± 18.4 to 201.4 ± 17.1 nm with negative surface charge. However, the yield obtained increased as the initiator was altered from KPS to V50, and when the acrylic acid molar ratio was increased from 1:1 to 1:3. In conclusion, changing the initiator and monomer molar ratio may affect the physicochemical properties of the nanocarriers and the %yield of the nanocarrier product. Further investigations are essential to obtain the favorable drug nanocarriers for drug delivery.

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“…Various polymer carriers of drugs, such as liposomes, polymerosomes, micelles, nanocages, and dendrimers, also are known [13][14][15][16][17][18][19][20][21]. These carriers usually are synthesized through the emulsion polymerization [22,23], self-assembly process [24], phase separation [25], and through the formation of micelles [26,27], etc. Furthermore, hollow polymer nanocapsules also are known [28,29], which usually are prepared through the layer-by-layer deposition of polymer chains on a template followed by the extraction of the template.…”

Section: Introductionmentioning

confidence: 99%

Nanoporous capsules of block co-polymers of [(MeO-PEG-NH)-b-(L-GluA)]-PCL for the controlled release of anticancer drugs for therapeutic applications

et al. 2016

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Herein, new nanoporous capsules of the block co-polymers of MeO-PEG-NH-(L-GluA)10 and polycaprolactone (PCL) have been synthesized through a surfactant-free cost-effective self-assembled soft-templating approach for the controlled release of drugs and for therapeutic applications. The nanoporous polymer capsules are designed to be biocompatible and are capable of encapsulating anticancer drugs (e.g., doxorubicin hydrochloride (DOX) and imatinib mesylate (ITM)) with a high extent (∼279 and ∼480 ng μg(-1), respectively). We have developed a nanoformulation of porous MeO-PEG-NH-(L-GluA)10-PCL capsules with DOX and ITM. The porous polymer nanoformulations have been programmed in terms of the release of anticancer drugs with a desired dose to treat the leukemia (K562) and human carcinoma cells (HepG2) in vitro and show promising IC50 values with a very high mortality of cancer cells (up to ∼96.6%). Our nanoformulation arrests the cell divisions due to 'cellular scenescence' and kills the cancer cells specifically. The present findings could enrich the effectiveness of idiosyncratic nanoporous polymer capsules for use in various other nanomedicinal and biomedical applications, such as for killing cancer cells, immune therapy, and gene delivery.

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Synthesis and characterization of novel drug delivery nanoparticles based on polyzwitterionic copolymers

Cited by 4 publications

References 22 publications

Design and Concept of Polyzwitterionic Copolymer Microgel Drug Delivery Systems In Situ Loaded with Non-steroidal Anti-inflammatory Ibuprofen

Design and Concept of Polyzwitterionic Copolymer Microgel Drug Delivery Systems In Situ Loaded with Non-steroidal Anti-inflammatory Ibuprofen

Synthesis of N-vinylpyrrolidone/Acrylic acid nanoparticles for drug delivery: Method optimization

Nanoporous capsules of block co-polymers of [(MeO-PEG-NH)-b-(L-GluA)]-PCL for the controlled release of anticancer drugs for therapeutic applications

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