Synthesis and Characterization of Novel Chickpea Protein Hydrolysate-Vanadium Complexes Having Cell Inhibitory Effects on Lung Cancer A549 Cells Lines

Mukhamedov, N.; Wubulikasimu, Atikan; Rustamova, Nigora; Nuerxiati, Rehebati; Mirzaakhmedov, Sharafitdin; Ishimov, Uchqun; Ziyavitdinov, Jamolitdin F.; Yili, Abulimiti; Aisa, Haji Akber

doi:10.1007/s10930-021-09979-4

Cited by 11 publications

(5 citation statements)

References 38 publications

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“…(e) Molecular docking simulations for the DEDEQIPSHPPR–calcium complex (soybean peptide) (Gan, Kong, et al., 2022). (f) Structures of HKERVQLHIIPTAVGK (chickpea protein peptide) and its zinc complex illustrated by MOE (Mukhamedov et al., 2023).…”

Section: Discussion Of the Chelation Mechanism Based On Amino Acid Se...mentioning

confidence: 99%

A critical review of a typical research system for food‐derived metal‐chelating peptides: Production, characterization, identification, digestion, and absorption

Yu,

Liu,

Zhou

2023

Comp Rev Food Sci Food Safe

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In the past decade, food‐derived metal‐chelating peptides (MCPs) have attracted significant attention from researchers working towards the prevention of metal (viz., iron, zinc, and calcium) deficiency phenomenon by primarily inhibiting the precipitation of metals caused by the gastrointestinal environment and exogenous substances (including phytic and oxalic acids). However, for the improvement of limits of current knowledge foundations and future investigation directions of MCP or their derivatives, several review categories should be improved and emphasized. The species’ uniqueness and differences in MCP productions highly contribute to the different values of chelating ability with particular metal ions, whereas comprehensive reviews of chelation characterization determined by various kinds of technique support different horizons for explaining the chelation and offer options for the selection of characterization methods. The reviews of chelation mechanism clearly demonstrate the involvement of potential groups and atoms in chelating metal ions. The discussions of digestive stability and absorption in various kinds of absorption model in vitro and in vivo as well as the theory of involved cellular absorption channels and pathways are systematically reviewed and highlighted compared with previous reports as well. Meanwhile, the chelation mechanism on the molecular docking level, the binding mechanism in amino acid identification level, the utilizations of everted rat gut sac model for absorption, and the involvement of cellular absorption channels and pathway are strongly recommended as novelty in this review. This review makes a novel contribution to the literature by the comprehensive prospects for the research and development of food‐derived mineral supplements.

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Section: Discussion Of the Chelation Mechanism Based On Amino Acid Se...mentioning

confidence: 99%

A critical review of a typical research system for food‐derived metal‐chelating peptides: Production, characterization, identification, digestion, and absorption

Yu,

Liu,

Zhou

2023

Comp Rev Food Sci Food Safe

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“…The cytotoxic activity of the total extracts of all fungal endophytes was tested against three human cancer cells lines: HT-29 (colon cancer), MCF-7 (breast cancer), and HeLa (cervical cancer). An MTT assay was carried out as described, with minor modifications [ 70 , 71 , 72 ]. The samples were dissolved in DMSO; the extract concentration was 50 μg/μL.…”

Section: Methodsmentioning

confidence: 99%

Diversity and Biological Activities of Endophytic Fungi from the Flowers of the Medicinal Plant Vernonia anthelmintica

Litao

Rustamova

Ning

et al. 2022

IJMS

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Secondary metabolites produced by endophytic fungi are an important source of biologically active compounds. The current research was focused on the biological activities of ethyl acetate extracts of fungi, isolated and identified from Vernonia anthelmintica flowers for the first time. In addition, an investigation of the non-polar chemical composition of dichloromethane-ethyl acetate extracts of the most active fungal strain was carried out. The isolates included Ovatospora senegalensis NR-03, Chaetomium globosum NR-04, Thielavia subthermophila NR-06, Aspergillus calidoustus NR-10, Aspergillus keveii XJF-23 and Aspergillus terreus XJF-3 species. Strains were identified by 18S rRNA gene sequencing methods and were registered in GenBank. Crude extracts of the fungi displayed in vitro biological activities, including antimicrobial and cytotoxic activities. A melanin content assay was performed on murine B16 cells. An ethyl acetate extract of O. senegalensis NR-03 showed high anticancer and antimicrobial activity; therefore, we also studied the non-polar chemical composition of the dichloromethane-ethyl acetate fraction and identified 52 non-polar compounds with the different medium. This investigation discovered that the secondary metabolites of the total extract of endophytic fungi could be a potential source of alternative natural antimicrobial, cytotoxic and melanin synthesis activity in their host plant, and the isolation of bioactive metabolites may provide a lead to new compounds of pharmaceutical significance.

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“…Similarly, several peptides, obtained by hydrolyzing chickpea seed proteins, were found to increase the cytotoxic effects of vanadium oxides that were attributed to cell penetrating suggestions (Mukhamedov et al, 2021). The MVRRFLVTLRIRRACGPPRVRV sequence, derived from the N-end of p14ARF, a tumor suppressor that is deregulated in many cancer types, was found to decrease cell proliferation and lead to induction of apoptosis (Johansson et al, 2008).…”

Section: Strategies To Enhance the Efficiency Of Cppsmentioning

confidence: 98%

Cell penetrating peptides: Highlighting points in cancer therapy

Asrorov

Wang

Zhang

et al. 2023

Drug Development Research

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Cell‐penetrating peptides (CPPs), first identified in HIV a few decades ago, deserved great attention in the last two decades; especially to support the penetration of anticancer drug means. In the drug delivery discipline, they have been involved in various approaches from mixing with hydrophobic drugs to the use of genetically conjugated proteins. The early classification as cationic and amphipathic CPPs has been extended to a few more classes such as hydrophobic and cyclic CPPs so far. Developing potential sequences utilized almost all methods of modern science: choosing high‐efficiency peptides from natural protein sequences, sequence‐based comparison, amino acid substitution, obtaining chemical and/or genetic conjugations, in silico approaches, in vitro analysis, animal experiments, etc. The bottleneck effect in this discipline reveals the complications that modern science faces in drug delivery research. Most CPP‐based drug delivery systems (DDSs) efficiently inhibited tumor volume and weight in mice, but only in rare cases reduced their levels and continued further processes. The integration of chemical synthesis into the development of CPPs made a significant contribution and even reached the clinical stage as a diagnostic tool. But constrained efforts still face serious problems in overcoming biobarriers to reach further achievements. In this work, we reviewed the roles of CPPs in anticancer drug delivery, focusing on their amino acid composition and sequences. As the most suitable point, we relied on significant changes in tumor volume in mice resulting from CPPs. We provide a review of individual CPPs and/or their derivatives in a separate subsection.

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Synthesis and Characterization of Novel Chickpea Protein Hydrolysate-Vanadium Complexes Having Cell Inhibitory Effects on Lung Cancer A549 Cells Lines

Cited by 11 publications

References 38 publications

A critical review of a typical research system for food‐derived metal‐chelating peptides: Production, characterization, identification, digestion, and absorption

A critical review of a typical research system for food‐derived metal‐chelating peptides: Production, characterization, identification, digestion, and absorption

Diversity and Biological Activities of Endophytic Fungi from the Flowers of the Medicinal Plant Vernonia anthelmintica

Cell penetrating peptides: Highlighting points in cancer therapy

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