Synthesis and Characterization of Novel Five-Membered Heterocycles and Their Activity against Candida Yeasts

Abstract

Some new tetrazole derivatives were prepared by the reaction between the prepared azomethine compounds I 6-I 10 with sodium azide in anhydrous tetrahydrofuran (THF) with a few drops of distilled water and under reflux conditions. Azomethine compounds were prepared by thermal condensation reactions of aromatic aldehydes with primary aromatic amines. The prepared compounds (tetrazole derivatives) were screened for their antibacterial activity (by disc diffusion method). Compound I 6 is the most active derivative that has recorded a significantly (p<0.01) stronger influence to inhibit the growth of Candida zeylanoides with an average zone of inhibition of 26.0 mm. Derivatives I 7 and I 9 showed the lowest zone of inhibition of 8.0 mm against Candida zeylanoides. This study may be helpful in designing more potential anticandidal agents for therapeutic use in the future.

Preparation of some metallic complexes from selected organic ligands and characterization it spectrophotometry as a model of a ligand scavenger to metals in health applications

“…General procedure for prepare of imine compounds [5][6][7][8]: Imine compounds are preparation by mixing 0.01moleof amine and 0.02 mole ofaldehydepresence trace of glacial acetic acid in 25 mL abs. ethanol, the reaction completed for 4hours, the purity of the Imine compounds were monitored with Thin Lear Chromatography.…”

Synthesizes, characterization, molecular modelling studies and bioactivity of a novel bicyclic compound of δ-lactam with oxazepine ring containing-sulphur substitute using an economic method

“…The inhibition zone of 100% was less than the inhibition zone of 80%. This is due to the fact that the high concentration of 100% prevents the spread of the lactozepine well [33]. Antioxidant activity of the synthesise compound was also assessed in order to examine the ability of the compound to scavenge the free radicals using the DPPH reagent in a free radical scavenging assay.…”

Discovery of a new fungicide by screening triazole sulfonylhydrazone derivatives and its downy mildew inhibition in cucumber

“…On the other hand, hydrazones (iNHN=C‐1) are known as biologically active fragements, which are widely used as a scaffold in agricultural chemistry . It has been reported that derivatives of hydrazones are shown to possess a wide range of biological activities, such as antifungal, antibacterial, insecticidal, herbicidal, antiviral and anticancer activities . Heretofore, some pharmaceutical companies have developed dozens of fungicides, insecticides, plant growth regulators such as benquinox, hydramethylnon and diflufenzopyr .…”

“…[31][32][33] It has been reported that derivatives of hydrazones are shown to possess a wide range of biological activities, such as antifungal, antibacterial, insecticidal, herbicidal, antiviral and anticancer activities. [34][35][36][37][38][39] Heretofore, some pharmaceutical companies have developed dozens of fungicides, insecticides, plant growth regulators such as benquinox, hydramethylnon and diflufenzopyr. [40][41][42] All of the findings inspired us to design the bioactive structures with these functional motifs as potential agrochemical leads for plant disease control.…”