Synthesis and characterization of NiFe2O4 magnetic nanoparticles with different coating materials for magnetic particle imaging (MPI)

Magnetic particle imaging: tracer development and the biomedical applications of a radiation-free, sensitive, and quantitative imaging modality

“…Irfan et al synthesised small Ni-ferrite nanoparticles (9–12 nm), functionalised with either a citric acid (CA) or polyacrylic acid (PAA) coating. 255 The MPI performance of the superparamagnetic NiFe 2 O 4 @CA and NiFe 2 O 4 @PAA nanoparticles was evaluated, both showcasing an improved FWHM over commercially available VivoTrax and Perimag SPIONs. In a different study, Du et al designed monodisperse single-core Mn-ferrite nanoparticles, with the intention of producing a highly sensitive tracer with good multi-modal MRI/MPI performance and impressive MFH properties.…”

Comprehensive Evaluation of Magnetic Particle Imaging (MPI) Scanners for Biomedical Applications

“…MPI uses superparamagnetic iron oxide nanoparticles (SPIONs) as a tracer to carry out a scan of the objects (phantoms, In-vitro, and In-vivo applications) [88]. MPI exploits the nonlinear magnetization behavior of the nanoparticles to the applied magnetic field.…”

Characterization and Applications of Metal Ferrite Nanocomposites

“…The superparamagnetic response and biocompatibility of magnetic NPs make them potential candidates as contrast agents in magnetic resonance imaging (MRI) and tracer agents in magnetic particle imaging (MPI). Due to its soft magnetic behavior, NiFe 2 O 4 is used as a contrast agent in MRI [189]. NiFe 2 O 4 @PAA composites (PAA -polyacrylic acid) could be considered as potential tracer agents for MPI, outperforming the commercial, commonly used tracer agents due to the minimum relaxation time of 3.10 μs and high resolution of 7.75 mT, [189].…”

“…Due to its soft magnetic behavior, NiFe 2 O 4 is used as a contrast agent in MRI [189]. NiFe 2 O 4 @PAA composites (PAA -polyacrylic acid) could be considered as potential tracer agents for MPI, outperforming the commercial, commonly used tracer agents due to the minimum relaxation time of 3.10 μs and high resolution of 7.75 mT, [189]. Besides its use in photothermal and sonodynamic therapy of melanoma, MnFe 2 O 4 /C nanocomposite may also be used as a novel theranostic agent in nanomedicine [190].…”