Synthesis and characterization of new O,O‐diethyl phosphorothioates derived from substituted tetrazolo[1,5‐a]quinolin‐ 4‐ylmethanol derivatives

Abstract

A simple and convenient method is developed for the synthesis of new O,O-diethyl O-(substituted tetrazolo[1,5-a]quinolin-4-yl)methyl phosphorothioates, which has been synthesized for the first time from tetrazolo[1,5-a] quinolines via tetrazolo[1,5-a]quinolin-4-ylmethanol derivatives.The structures of the all newly synthesized compounds were elucidated by analytical and spectral methods.

An Efficient Synthesis of 3,4-Dihydro-3-substituted-2H-naphtho[2,1-e][1,3]oxazine Derivatives Catalyzed by Zirconyl(IV) Chloride and Evaluation of its Biological Activities

“…Several methods for the preparation of 1,3-oxazine derivatives have previously been reported. [20][21][22][23][24] As per our interest [25][26][27][28][29][30] to develop better protocols for the synthesis of biologically active heterocyclic molecules, we would like to report the synthesis of a series of new 3,4-dihydro-3-substituted-2H-naphtho[2,1-e][1,3]oxazine derivatives using 1-naphthol, formalin and various anilines as substrates in presence of zirconyl(IV) chloride (ZrOCl2) catalyst. To the best of our knowledge there is no report on the one-pot synthesis of 3,4-dihydro-3-substituted-2H-naphtho[2,1-e][1,3]oxazines using ZrOCl 2 as a catalyst.…”