Synthesis and Characterization of New Chalcone Derivatives of Aryl-Himachalene

Edder, Youssef; Lahcen, Intissar Ait; Faris, Abdelmoujoud; Fdil, Naı̈ma; Boualy, Brahim; Karim, Abdallah

doi:10.1080/00304948.2020.1751562

Cited by 4 publications

(1 citation statement)

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“…Herein, as a part of our ongoing study targeting himachalenes as a starting material for the development of new functionalized sesquiterpenes of highly added value 13 – 19 , we report a first total synthesis of trans-himachalol ( 5) from himachalenes, readily and abundantly available sesquiterpenes, in five steps.…”

Section: Introductionmentioning

confidence: 99%

From himachalenes to trans-himachalol: unveiling bioactivity through hemisynthesis and molecular docking analysis

Faris,

Edder,

Louchachha

et al. 2023

Sci Rep

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In this study, we report the first total hemisynthesis of trans-himachalol sesquiterpene, a stereoisomer of the natural cis-himachalol isolated from Cedrus atlantica essential oils, from himachalenes mixture in five steps. Reactions conditions were optimized and structures of the obtained compounds were confirmed by IR, mass spectra, 1H, and 13C NMR. The synthesized compounds were investigated for potential activities on various isolated smooth muscles and against different neurotransmitters using molecular docking. The results show that the synthesized compounds display high affinities towards the active site of the protein 7B2W and the compounds exhibit promising activities on various isolated smooth muscles and against different neurotransmitters.

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Section: Introductionmentioning

confidence: 99%