Synthesis and characterization of new complexes of nickel (II), palladium (II) and platinum(II) with derived sulfonamide ligand: Structure, DFT study, antibacterial and cytotoxicity activities

Bouchoucha, Afaf; Zaater, Sihem; Bouacida, Sofiane; Mérazig, Hocine; Djabbar, Safia

doi:10.1016/j.molstruc.2018.02.057

Cited by 98 publications

(33 citation statements)

References 56 publications

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“…These absorption ranges correspond to the composition of well-selected octahedral configuration around Ni (II) [58][59][60]. The observed magnetic moment values (table 1) of nickel complexes indicate the paramagnetic nature of Ni (II), which confirms the octahedral structure of these nickel complexes [30,37,38]. 112…”

Section: Nmmentioning

confidence: 69%

“…In the free ligands the HOMO is located on complexes. The energy gaps (∆E) of L 3 and L 4 complexes are the smallest suggesting a lower stability and a higher antimicrobial activity for these two complexes than the rest of the complexes [38]. Fig.…”

Section: Frontier Molecular Orbitalsmentioning

confidence: 91%

“…About 1 ml of young bacterial and fungal inocula containing approximately 10 6 CFU/ml Colony Forming Unite was spread on the surface of the nutrient agar and Sabouraud Dextrose Broth, with the help of a sterile cotton swab. The tested compounds were dissolved in DMSO solvent at concentration of 5 and 10 mg/ml [37,38]. The wells (6mm in diameter) were punched carefully using a sterile Pipette Pasteur and 25µL of tested solutions at different concentrations were added into each labeled well.…”

Section: Biological Studiesmentioning

confidence: 99%

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Impact of the functionalized tetrazole ring on the electrochemical behavior and biological activities of novel nickel (II) complexes with a series of tetrazole derivatives

Allab

Chikhi

Zaater

et al. 2020

Inorganica Chimica Acta

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Six new nickel (II) complexes with a series of tetrazole derivatives functionalized by different substituents {5-(2-(1-Benzyltetrazol-5-yl) phenyl)-2-ethyl-4-methylthiazole (L 1), 1-Benzyl-5-(2-(1methylpyrrol-2-yl)phenyl) tetrazole (L 2), 5-(2-(1-Pivalyltetrazol-5-yl)phenyl)-2-ethyl-4methylthiazole (L 3), 5-(2-(1-Methylpyrrol-2-yl) phenyl)-1-pivalyltetrazole (L 4), 2-Ethyl-4-methyl-5-(2-(1 methyltetrazol-5-yl) phenyl) thiazole (L 5) and 1-Methyl-5-(2-(1-methylpyrrol-2-yl)phenyl) tetrazole (L 6)} have been synthesized and characterized by analytical and spectral methods. The data clearly indicated that the nickel (II) complexes are coordinated to the monodentate tetrazole derivatives via nitrogen (N3) atom of the tetrazole ring. The octahedral geometry is observed for all the complexes. The thermogravimetric analysis revealed the presence of coordinated and hydrated water molecules in the coordination sphere. The DFT calculations performed on both the ligands and the complexes allowed to optimize the structures, the stability and to explain the electrochemical behavior and the biological activities of the nickel (II) complexes. The study of the substituents effects on the redox properties of the ligands and their nickel (II) complexes were discussed via cyclic voltammograms. Electron donating substituents shift the reduction potentials toward negative values, while anodic shift of the oxidation potentials is manifested by the substituents having an electron withdrawing effect. The in vitro antimicrobial activities of the ligands and their corresponding nickel (II) complexes have been evaluated against four bacterial and two fungal strains.

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Section: Nmmentioning

confidence: 69%

Section: Frontier Molecular Orbitalsmentioning

confidence: 91%

Section: Biological Studiesmentioning

confidence: 99%

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Impact of the functionalized tetrazole ring on the electrochemical behavior and biological activities of novel nickel (II) complexes with a series of tetrazole derivatives

Allab

Chikhi

Zaater

et al. 2020

Inorganica Chimica Acta

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“…HOMO and LUMO molecular orbitals play a significant role in understanding intramolecular charge transfer (ICT) . Within molecules, the HOMO is localized on electron‐rich moieties and demonstrates the capability to donate electrons.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and photophysical studies on a new fluorescent phenothiazine‐based derivative

et al. 2020

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A new typical phenothiazine compound functionalized with thienyl-indandione derivative (PTZTID) was synthesized and characterized using spectral analysis (ultraviolet-visible (UV-vis) light, infrared (IR), 1 H nuclear magnetic resonance (NMR) and 13 C NMR tools). The UV-vis absorption spectra of the PTZTID solution in 1,4-dioxane showed two absorption bands attributed to localized aromatic π-π* transitions of conjugated aromatic moieties and intramolecular charge transfer with the characteristics of a π-π* transition. The fluorescence spectra exhibited a maximum emission wavelength at 580 nm. The effect of concentration on photophysical properties took the form of a minor hypsochromic shift, which was attributed to some extent to the occurrence of H-type aggregation of the PTZTID derivative. Binary solvent effects on the spectroscopic behaviour of PTZTID were measured at different H 2 O/1,4-dioxane ratios. Similarly, when increasing the water content, a hypsochromic shift was observed that resulted from H-type aggregation.Furthermore, geometry and electronic configurations of PTZTID were studied at density functional theory /B3LYP level and indicated that the compound had a nonplanar (butterfly structure). K E Y W O R D Scomputational studies, density functional theory, fluorescence, PTZTID

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“…41,42 Moreover, the HOMO-LUMO energy gap decrease shows the ease of charge transfer interactions, which may be responsible for the bioactivity of the molecules. 43 The 3D plots of frontier orbitals in the optimized geometry denote the red color for positive phase and the green one for the negative phase of wave function as shown in Fig. 2.…”

Section: Computational Studiesmentioning

confidence: 99%

Synthesis of new thienylpicolinamidine derivatives and possible mechanisms of antiproliferative activity

et al. 2020

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Synthesis and characterization of new complexes of nickel (II), palladium (II) and platinum(II) with derived sulfonamide ligand: Structure, DFT study, antibacterial and cytotoxicity activities

Cited by 98 publications

References 56 publications

Impact of the functionalized tetrazole ring on the electrochemical behavior and biological activities of novel nickel (II) complexes with a series of tetrazole derivatives

Impact of the functionalized tetrazole ring on the electrochemical behavior and biological activities of novel nickel (II) complexes with a series of tetrazole derivatives

Synthesis and photophysical studies on a new fluorescent phenothiazine‐based derivative

Synthesis of new thienylpicolinamidine derivatives and possible mechanisms of antiproliferative activity

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