Synthesis and characterization of new 1H-pyrazolo[3,4-b]pyridine phosphoramidate derivatives

Abstract

Twelve new 1H-pyrazolo [3,4-b]pyridine phosphoramidate derivatives were synthesized under mild conditions by nucleophilic aromatic substitution reaction of aminoalkylphosphoramidates over 4-Cl substituted pyrazolo [3,4-b]pyridine in good yields. The new compounds were characterized by IR, 1 H, 13 C and 31 P NMR spectroscopy and HRMS. The crystal structure of one compound was solved by X-ray diffraction and showed a network of intermolecular interactions involving phosphoramidate groups.

Synthesis and Application of [Zr-UiO-66-PDC-SO3H]Cl MOFs at The Preparation of Dicyanomethylene Pyridines via Chemical and Electrochemical Methods

“…19,20 These compounds have been applied as drugs for cancer, malaria, HIV, antimicrobial, anti-tumor, antifungal, anticonvulsant, antihypertension and urinary incontinence treatment. [19][20][21][22][23][24][25][26][27] On the other hand, the chemical reactivity is very complex. Numerous factors control the reaction mechanisms which are subject of everyday experiences.…”