Synthesis and Characterization of New 1,2-Dihydropyridine-3-Carbonitrile Compounds with Study of Expected Biological Activity

Ibraheem, Hiba H.; Al-Majedy, Yasameen K.; Salim, Ali; Al-Bayati, Redha I.

doi:10.22401/jnus.21.2.07

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…According to the diffusion process, the synthesized compounds were tested for antifungal activity against Candida albicans, and antibacterial gram-positive Staphylococcus aureus, Streptococcus epidermidis, and gram-negative E. coli, Klebsiella sp. [15] at a concentration of 10µg/L and 1µg/L Ampicillin and Fluconazole were used as standards for antibacterial and antifungal activity respectively.…”

Section: Evaluation Of Antibacterial and Antifungal Assaymentioning

confidence: 99%

Synthesis, Biological Evaluation and Quantum Chemical Studies of novel 3-Acetylpyridin-2(1H)-one Derivative

Al-Majedy¹,

Al-Majedy²,

Issa³

2022

Preprint

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2, 4-dihydroxybenzaldehyde reacts for ethyl acetoacetate yielded 3-acetyl-7-hydroxy-2H-chromen-2-one (1), which was then cyclized with ethyl acetoacetate in the presence of ammonium acetate to give compound 3-acetyl-4-(4-(dimethylamino) phenyl) -6-(7-hydroxy-2-oxo-2H-chromen-3-yl)pyridin-2(1H)-one (2). Melting point, TLC, FT-IR spectroscopy, and 1H-NMR were used to characterize the newly synthesized compound. Pyridine (2) is a synthetic compound. Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebsiella sp., and Candida albicans were chosen for their antibacterial and antifungal properties. Compounds 2 demonstrated strong antibacterial activity when compared to the regular drug Ampicillin using the diffusion process. Compound 2 showed high antifungal efficacy as compared to the standard medication fluconazole. The results demonstrated that the tested compounds 1 and 2 have substantially stronger antioxidant activity than the well-known antioxidant ascorbic acid. They had a high ability for scavenging DPPH and hydroxyl radicals. Quantum chemical parameters for the highest occupied molecular orbital energy (EHOMO) and the lowest unoccupied molecular orbital energy (ELUMO) were determined and presented.

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Section: Evaluation Of Antibacterial and Antifungal Assaymentioning

confidence: 99%

Synthesis, Biological Evaluation and Quantum Chemical Studies of novel 3-Acetylpyridin-2(1H)-one Derivative

Al-Majedy¹,

Al-Majedy²,

Issa³

2022

Preprint

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“…gram negative and fungal infections (Candida albicans). Employ nutrient agar medium by way of very well diffusion method [13,14]. All derivatives compound were pendent within water solutions at various concentrations spread from one mg and 0.01 mg within one hundred mL.…”

Section: Synthesis Of Acid Hydrazide Derivative (4)mentioning

confidence: 99%

Synthesis, Characterization and Biological Activity of Some Heterocyclic Compounds Containing Quinoline Molecule

Hameed

Ibraheem

2020

ANJS

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This work includes "organic" composition while biologically probe for several modern heterocyclic derivatives via 3 steps: Firstly synthesis from some 5-membered. heterocyclic derivatives (Pyrazole while isoindoline-1,3-dione) from quinoline. Secondly included characterized and confirmed by using melting point, TLC, infrared spectrum analysis while 1 H-NMR. Thirdly ncluded the examination of biological activity of some components against (4) varieties of pathogen bacteria (Staphylococcus aureus, Staphylococcus epidermidis) gram-positive and (Escherichia coli, Klebsiella sp.) gram-negative and fungal infections (Candida albicans). The results of whole derivatives show stellar biological activity compared to antibiotics (gentamycin).

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Synthesis and Biological evaluation of Novel Nicotinonitrile derivatives derived from N-Substituted Coumarinyl Chalcones

Mohammed

Ibraheem

Hussein

2021

J. Phys.: Conf. Ser.

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This work included synthesis of several new pyridine derivatives (3a-c) by cyclization of Coumarinyl Chalcones (2a-c) with malononitrile in presence of ammonium acetate. Prepared compounds were diagnosed using Melting point, TLC, FT-IR spectroscopy and 1H-NMR. The synthesized pyridines (3a-c) were screnned for their antibacterial and antifungal activity against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebsiella sp., and Candida albicans. Respectively by diffusion method compounds 3a, 3b and 3c showed good antibacterial activity and by comparison with the medicine Ampicillin. Compounds 3a, 3b and 3c showed moderate antifungal activity compared to the standard drug fluconazole.

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Synthesis and Characterization of New 1,2-Dihydropyridine-3-Carbonitrile Compounds with Study of Expected Biological Activity

Cited by 3 publications

References 16 publications

Synthesis, Biological Evaluation and Quantum Chemical Studies of novel 3-Acetylpyridin-2(1H)-one Derivative

Synthesis, Biological Evaluation and Quantum Chemical Studies of novel 3-Acetylpyridin-2(1H)-one Derivative

Synthesis, Characterization and Biological Activity of Some Heterocyclic Compounds Containing Quinoline Molecule

Synthesis and Biological evaluation of Novel Nicotinonitrile derivatives derived from N-Substituted Coumarinyl Chalcones

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