Synthesis and characterization of new hydrogels on the basis of water‐soluble maleic anhydride copolymers with γ‐aminopropyltriethoxysilane

Abstract

This work describes the synthesis and macromolecular reactions of maleic anhydride (MA)-acrylic acid (AA) binary reactive copolymers with ␥-aminopropyltriethoxysilane (APTS) as a polyfunctional crosslinker. Copolymers with a given composition of MA-AA (47.17-52.83 wt %) were synthesized by radical binary copolymerization with benzoyl peroxide as an initiator in p-dioxane at 70°C in nitrogen atmosphere and initial monomer ratio of 1 : 1. It is shown that the network structure is formed in MA-AA/ APTS in water by intermolecular reaction between the anhydride unit and the amine group, as well as between the etoxysilyl fragment and free carboxyl groups of the acrylic acid and maleic anhydride unit. Swelling parameters such as beginning time of hydrogel formation, initial rate of swelling, swelling rate constant, equilibrium swelling, and equilibrium water content were determined for copolymer/ APTS/water systems with various copolymer/crosslinker ratios. Formation of a hyperbranched network structure through the fragmentation of side-chain reactive groups in the studied systems was confirmed by FTIR, TGA, and DSC methods.

Effect of Ni(II), Cd(II), and Cu(II) metal ions on the crystallinity of poly(maleic anhydride‐alt‐acrylic acid)

“…When the polar polymers process H‐bonding capability, the most energetically favored crystal structure will tend to capitalize on these features. The synthesized copolymer by the use of 1 : 1 M ratios of initial monomers, respectively, had the following characteristics 11…”

Synthesis and antitumor activity of poly(3,4‐dihydro‐2H‐pyran‐co‐maleic anhydride‐co‐vinyl acetate)

“…Previously, we observed a similar effect for binary and ternary copolymers of an MA/VA/acrylic acid monomer system. 26,27 It was shown that the VA linkages in the terpolymer imparted immobility to the polymer chains and low polyanionic character. 27 The hydrolyzed copolymer has sufficiently high antitumor activity, which depends on the amount of hydrogen-bonding carboxylic groups and their regular distribution in the side chains of functional macromolecules.…”

Design, Synthesis and Characterization of 3,4-Dihydro-2H-pyran Containing Copolymer/Clay Nanocomposites

“…Water-soluble anhydride-containing copolymers, used as polyanions, and their functional derivatives have high biological and physiological activity and, in particular, antimicrobial and antitumor properties (12)(13)(14). Especially pyran containing copolymers and terpolymers of 3,4-dihydro-2H-pyran (DHP) including poly (DHP-alt-MA) are linked to a class of high performance bioengineering polymers which have a wide range of applications in bio-and gene-engineering processing, and drug delivery systems as effective agents, enzyme carriers and bioconjugates (11)(12)(13)(14)(15)(16). 3,4-Dihydro-2H-pyran (DHP) and its derivate undergo complex-radical alternating copolymerization with MA with ease (12).…”

“…The last one is melt processing method in which intercalation and exfoliation of layered silicates in polymeric matrix is applied during mat (10)(11)(12)(13)(14)(15). Clay and their modified organic derivatives are characterized employing not only simple, but also modern characterization methods including identification of chemical compositions by gravimetric analysis, inductively coupled plasma (ICP) or XRF, cation exchange capacity (CEC) using standard ammonium acetate method, surface area measurement, Fourier transform infrared spectroscopy (FTIR), powdered X-ray diffraction (XRD) and others (15)(16)(17)(18)(19). The instrumental techniques, mainly FTIR and XRD, are essential methods for determination of clay structure.…”