Synthesis and characterization of new copolymers of ethyl methacrylate grafted on tapioca starch as novel excipients for direct compression matrix tablets

Casas, Marta; Ferrero, C; de-Paz, M.-Violante; Jiménez-Castellanos, M.R.

doi:10.1016/j.eurpolymj.2009.02.019

Cited by 29 publications

(25 citation statements)

References 43 publications

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“…(Casas et al, 2009, Marinich et al, 2012 A grafting chainderived acrylic layer led to enzymatic resistance and hydrophobic behavior. (Alias et al, 2007) Fickian diffusion is the principal mechanism in most formulations.…”

Section: Influence Factors Summary Referencesmentioning

confidence: 99%

“…To some drugs, the release is an anomalous transport. (Casas et al, 2009;Marinich et al, 2012) to human health. As a personal point of view, enzymatically modified starch as extended-release excipient in oral tablets has a good application prospect.…”

Section: Influence Factors Summary Referencesmentioning

confidence: 99%

“…The products ovendried (OD) in vacuum exhibited lower plasticity and higher elasticity than the freezedried (FD) copolymers. (Casas et al, 2009) Drug type 1. The drug with higher solubility and higher friability is in accordance with the faster drug release.…”

Section: Influence Factors Summary Referencesmentioning

confidence: 99%

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Recent advances of starch-based excipients used in extended-release tablets: a review

Yan

Liu

2014

Drug Delivery

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In recent years, polysaccharides, including starch and its derivatives, have been widely used in the pharmaceutical industry, including as diluents, fillers, binders, disintegrants and glidants. The use of native starch as excipient in extended-release tablets is limited due to its low compactibility and enzymatic degradability, leading to the formation of weakly structured tablets. To overcome these limitations and expand the application of starch as an excipient, researchers have modified starch by physical and chemical methods, as well as by enzymatic hydrolysis. Some starch derivatives, including retrograded starch, pregelatinized starch, carboxymethyl starch, starch acetate, cross-linked starch and grafted starch have recently been introduced as excipients in oral tablets to control drug release. In this review, applications of starch and its derivatives as extended release excipients are reviewed and future frontiers are described.

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Section: Influence Factors Summary Referencesmentioning

confidence: 99%

Section: Influence Factors Summary Referencesmentioning

confidence: 99%

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Recent advances of starch-based excipients used in extended-release tablets: a review

Yan

Liu

2014

Drug Delivery

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“…are extensively studied for various biomedical applications. [9][10][11] Copolymers of N(-1,1-dimethyl-3-oxobutyl) acrylamide (DOBA) with hydroxyethyl methacrylate and isobutyl/cyclohexyl methacrylate, and hydroxyethyl methacrylate/vinyl acetate were also proposed as useful materials for contact lenses and other biomedical applications. [12,13] Poly(MMA) is a well-known material which possesses excellent optical characteristics, resistance to discolouration, light weight, and has been used for a variety of applications.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and swelling properties of copolymers of N(-1,1-dimethyll-3-oxobutyl)acrylamide with methyl methacrylate

Dodda

2013

Designed Monomers and Polymers

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To cite this article: Dodda Jagan Mohan (2014) Synthesis, characterization and swelling properties of copolymers of N(-1,1-dimethyll-3-oxobutyl)acrylamide with methyl methacrylate, Designed Monomers and Polymers, 17:5, 438-444, DOI: 10.1080/15685551.2013.867567 To link to this article: https://doi.org/10.1080/15685551.2013.867567 Copolymers of N(-1,1-dimethyl-3-oxobutyl)acrylamide (DOBA) and Methyl methacrylate (MMA) were prepared in dimethylformamide using benzoylperoxide as the initiator at 70°C. They were characterized by IR, 1 H NMR, and 13 C NMR. Copolymer compositions were determined by the analysis of 1 H NMR spectra. The weight and number average molecular weights of the polymers were determined by size exclusion chromatography. Monomer reactivity ratios were found to be 1.52 for MMA and 0.43 for DOBA according to Kelen-Tüdos method. Glass transition temperatures of the copolymers were determined by differential scanning calorimetry. The initial decomposition temperatures of the polymers were about 215°C as measured by thermogravimetric analysis under nitrogen atmosphere. Swelling properties of the polymers were measured in distilled water. Maximum water uptake of about 70% was observed for poly(DOBA). In case of copolymers, water uptake decreases with the increase of MMA content in the polymer chain.

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“…-the amorphization of organic materials consisting of small molecules (most APIs can be classified in this group) (Panchagnula & Bhardwaj, 2008); and -the amorphization of large polymer molecules (Casas et al, 2009). …”

Section: Amorphization In Pharmaceutical Technologymentioning

confidence: 99%

Amorphization of a crystalline active agent with the aim of pharmaceutical technological formulation

Laczkovich¹

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Synthesis and characterization of new copolymers of ethyl methacrylate grafted on tapioca starch as novel excipients for direct compression matrix tablets

Cited by 29 publications

References 43 publications

Recent advances of starch-based excipients used in extended-release tablets: a review

Recent advances of starch-based excipients used in extended-release tablets: a review

Synthesis, characterization and swelling properties of copolymers of N(-1,1-dimethyll-3-oxobutyl)acrylamide with methyl methacrylate

Amorphization of a crystalline active agent with the aim of pharmaceutical technological formulation

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