Synthesis and Characterization of Nanostructured Lipid Nanocarriers for Enhanced Sun Protection Factor of Octyl p-methoxycinnamate

Prado, Alice Haddad do; Araújo, Jennifer Thayanne Cavalcante de; Eloy, Josimar O.; Fonseca-Santos, Bruno; Pereira-da-Silva, Marcelo A.; Peccinini, Rosângela Gonçalves

doi:10.1208/s12249-019-1547-0

Cited by 17 publications

(7 citation statements)

References 42 publications

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“…According to do Prado et al [26], less crystalline structures require less energy to promote the fusion of the compound; thus, lower enthalpy values are expected. Therefore, the reduction of ΔH due to TA incorporation into the nanoparticles suggest that this lipophilic liquid contributed to the formation of a more amorphous structure.…”

Section: Resultsmentioning

confidence: 99%

Assessment of the Technological Properties of Idebenone and Tocopheryl Acetate Co-Loaded Lipid Nanoparticles

et al. 2021

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Several liquid lipids have been proposed to obtain nanostructured lipid carriers (NLC) with improved efficiency. An attractive strategy is the use of oils that could elicit a synergic effect with the loaded drug. In this work, different percentages (0–4% w/w) of tocopheryl acetate (TA), an oily antioxidant, were used as liquid lipid to prepare NLC loading idebenone (IDE), a synthetic antioxidant investigated for the treatment of neurodegenerative and topical diseases. The technological properties of such NLC were evaluated, as well as the interactions among lipid core components. Loading different percentages of IDE (1–4% w/w) into NLC containing TA up to 4% w/w, no significant change of mean size and polydispersity index was observed. IDE loading capacity was 4% w/w but NLC containing IDE percentages greater than 1.5% w/w showed poor stability during long-term storage. Differential scanning calorimetry analyses highlighted linear relationships between peak temperature and TA percentages, while the enthalpy variation and recrystallization index values showed that increasing the percentage of TA led to less crystalline structure of the NLC core. Therefore, NLC co-loading IDE and TA could be useful to design new delivery systems for the treatment of diseases that could benefit from the co-administration of these antioxidants.

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Section: Resultsmentioning

confidence: 99%

Assessment of the Technological Properties of Idebenone and Tocopheryl Acetate Co-Loaded Lipid Nanoparticles

et al. 2021

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“…POPC confers greater fluidity to the lipid bilayer, which can result in a better adjustment of the bilayer components throughout the storage period, as reported for other lipid structures. 50,56 The addition of POPC to the RL liposomes made peptide encapsulation more difficult, as seen previously, but may improve liposome stability. Comparing the characteristics between formulations B and D, formulation D was even more stable, probably due to the Chol used in its composition.…”

Section: Stability Evaluationmentioning

confidence: 89%

“…the acyl chain and the RL molecule as a consequence of the intercalation of the POPC molecule between the rhamnolipids, characterizing the observed reduction in the HD of formulations B and D, which has previously been reported for phospholipid vesicles as well as other lipid compositions. 42,49,50 Chol had no apparent influence on the size or ZP of the RL liposomes. Chol is one of the most widely used co-solutes in vesicle systems.…”

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confidence: 85%

“…indicating that the peptide is effectively incorporated within the liposome and not on its surface. 50 The release behavior of the liposomal samples is summarized in the cumulative percentage release up to the maximum value predicted by the EE studies ( Figure 5). The use of POPC in the liposome preparations resulted in a reduction in particle size and the fastest peptide release for the B p sample (6 h for complete release).…”

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confidence: 99%

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Rhamnolipid-Based Liposomes as Promising Nano-Carriers for Enhancing the Antibacterial Activity of Peptides Derived from Bacterial Toxin-Antitoxin Systems

Sanches¹,

Rocha²,

Bedoya³

et al. 2021

IJN

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Background: Antimicrobial resistance poses substantial risks to human health. Thus, there is an urgent need for novel antimicrobial agents, including alternative compounds, such as peptides derived from bacterial toxin-antitoxin (TA) systems. ParELC3 is a synthetic peptide derived from the ParE toxin reported to be a good inhibitor of bacterial topoisomerases and is therefore a potential antibacterial agent. However, ParELC3 is inactive against bacteria due to its inability to cross the bacterial membranes. To circumvent this limitation we prepared and used rhamnolipid-based liposomes to carry and facilitate the passage of ParELC3 through the bacterial membrane to reach its intracellular target-the topoisomerases. Methods and Results: Small unilamellar liposome vesicles were prepared by sonication from three formulations that included 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine and cholesterol. ParELC3 was loaded with high efficiency into the liposomes. Characterization by DLS and TEM revealed the appropriate size, zeta potential, polydispersity index, and morphology. In vitro microbiological experiments showed that ParELC3 loaded-liposomes are more efficient (29 to 11 µmol•L −1) compared to the free peptide (>100 µmol•L −1) at inhibiting the growth of standard E. coli and S. aureus strains. RL liposomes showed high hemolytic activity but when prepared with POPC and Chol this activity had a significant reduction. Independently of the formulation, the vesicles had no detectable cytotoxicity to HepG2 cells, even at the highest concentrations tested (1.3 mmol•L −1 and 50 µmol•L −1 for rhamnolipid and ParELC3, respectively). Conclusion: The present findings suggest the potential use of rhamnolipid-based liposomes as nanocarrier systems to enhance the bioactivity of peptides.

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“…To overcome this limitation, the second generation of SLNs was developed and named as nanostructured lipid carriers (NLC). NLCs are composed of solid and liquid lipids at room and body temperature as well as lipids with different chain lengths that promote the formation of an imperfect crystal structure [ 54 - 60 ]. Thus, this structure avoids crystallization and allows free spaces for drug storage and improves drug loading, which makes them suitable for drug delivery into brain tumor cells.…”

Section: Lipid-based Drug Delivery Nanosystemsmentioning

confidence: 99%

Drug Delivery Nanosystems in Glioblastoma Multiforme Treatment: Current State of the Art

Filippo

Duarte

Luiz

et al. 2021

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: Glioblastoma multiforme (GBM) is the most common primary malignant Central Nervous System cancer, responsible for about 4% of all deaths associated with neoplasia, characterized as one of the most fatal human cancers. Tumor resection does not possess curative character, thereby radio and/or chemotherapy are often necessary for the treatment of GBM. However, drugs used in GBM chemotherapy present some limitations, such as side effects associated with nonspecific drug biodistribution as well as limited bioavailability, which limits their clinical use. To attenuate the systemic toxicity and overcome the poor bioavailability, a very attractive approach is drug encapsulation in drug delivery nanosystems. The main focus of this review is to explore the actual cancer global problem, enunciate barriers to overcome in the pharmacological treatment of GBM, as well as the most updated drug delivery nanosystems for GBM treatment and how they influence biopharmaceutical properties of anti-GBM drugs. The discussion will approach lipid-based and polymeric nanosystems, as well as inorganic nanoparticles, regarding their technical aspects as well as biological effects in GBM treatment. Furthermore, the current state of the art, challenges to overcome and future perspectives in GBM treatment will be discussed.

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Synthesis and Characterization of Nanostructured Lipid Nanocarriers for Enhanced Sun Protection Factor of Octyl p-methoxycinnamate

Cited by 17 publications

References 42 publications

Assessment of the Technological Properties of Idebenone and Tocopheryl Acetate Co-Loaded Lipid Nanoparticles

Assessment of the Technological Properties of Idebenone and Tocopheryl Acetate Co-Loaded Lipid Nanoparticles

Rhamnolipid-Based Liposomes as Promising Nano-Carriers for Enhancing the Antibacterial Activity of Peptides Derived from Bacterial Toxin-Antitoxin Systems

Drug Delivery Nanosystems in Glioblastoma Multiforme Treatment: Current State of the Art

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