Synthesis and characterization of nanoporous SiO2/pHEMA biocomposites

Liu, Yen Yu; Liu, Tse Ying; Chen, San‐Yuan; LIu, Dean-Mo

doi:10.1007/s10856-007-3355-4

Cited by 16 publications

(19 citation statements)

References 30 publications

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“…It should be pointed out that the existence of some pores in the composite can improve the bioactivity of the biomaterials effectively on the premise of the mechanical guarantee. Besides, the porosity is essential to allow fluids, tissue and bone in growth [19,20]. The results show an enhancement of hardness due to the nanoscale structures in consolidated materials.…”

Section: Titanium-al 2 O 3 Nanocompositesmentioning

confidence: 99%

Hybrid Ti‐ceramic bionanomaterials for medical engineering

Niespodziana

Jurczyk

Miklaszewski

et al. 2010

Phys. Status Solidi (c)

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In the last decade a great interest has been observed in the field of nanoscale materials. Commercially pure titanium as well as titanium alloys have become predominant in implantology. Low hardness and poor tribiological properties of titanium alloys may become critical factor when wear phenomena are involved. One of the methods that allow the change of properties of Ti alloys is the production of nanocomposites, which will exhibit the favorable mechanical properties of titanium and excellent biocompatibility and bioactivity of ceramics. In this work hybrid Ti‐x wt% ceramic (45S5 Bioglass, SiO2, Al2O3) bionanocomposites (x =0, 3 and 10) were prod‐uced by the combination of mechanical alloying and powder metallurgical process. Reinforced by 45S5 Bioglass, SiO2 or Al2O3 particles, Vickers hardness of Ti‐based nanocomposite is higher from two to six times in comparison with pure microcrystalline Ti. Additionally, the experimental results show that in Ringer's solution at 37 °C, Ti‐based nanocomposites have good corrosion resistance. On the other hand, in vitro studies show that these bionanocomposites have excellent biocompatibility and could integrate with bone (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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Section: Titanium-al 2 O 3 Nanocompositesmentioning

confidence: 99%

Hybrid Ti‐ceramic bionanomaterials for medical engineering

Niespodziana

Jurczyk

Miklaszewski

et al. 2010

Phys. Status Solidi (c)

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“…They have neither antigenicity nor cytotoxicity and can be processed into porous form for use as bone substitutes or scaffolds. 15,18,[40][41][42] However, their usage is limited because of their brittle nature and the difficulty in processing into highly porous structures with controlled porosity. 42,43 To overcome these disadvantages, HA and TCP are combined with polymers such as starch, PLLA, PLA, PE, chitosan and collagen, to make composite scaffolds.…”

Section: Bioceramicsmentioning

confidence: 99%

Development of biodegradable scaffolds for tissue engineering: A perspective on emerging technology

Liu¹,

Czernuszka²

2007

Materials Science and Technology

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The scaffold, a three-dimensional (3D) substrate that serves as a template for tissue regeneration, plays an essential role in tissue engineering. The ideal scaffold should have surface chemistry and microstructure tailored to facilitate cellular attachment, proliferation and differentiation; adequate mechanical strength for handling; and an appropriate biodegradation rate without undesirable byproducts. Research on biopolymer formulation and scaffold fabrication has been intense over the past 10 years. A perspective is provided of important issues related to scaffold development from biodegradable polymers. The mechanical properties and biocompatibility (including biodegradability and bioresorptability) of commonly used biopolymers are reviewed. Scaffold design and fabrication techniques are assessed and compared. Scaffold architecture, including pore size and size distribution, and its effects on cell growth are discussed. The importance of structural hierarchy over a range of length scales is highlighted. Unfortunately, conventional processing techniques cannot yet control both scaffold architecture and surface chemistry. An emerging scaffold fabricating technique using solid free form fabrication (SFF), although currently restricted to relatively symmetrical structures, has been shown to be highly effective in integrating structural architecture with changes in surface chemistry of the scaffolds, and integration of growth factors. Several examples of the application of SFF are presented.

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“…Methods for obtaining polymer/silica nanocomposites include: (a) mixing silica nanoparticles and the polymer [10][11][12][13][14], (b) sol-gel processes in presence of a solution of the organic polymer [10,13,[15][16][17][18], and (c) in situ sol-gel process and simultaneous polymerization [12,14,19]. Introduction of functional groups along the backbone of the polymer can favor the formation of covalent bonds between organic and inorganic phases during sol-gel reaction [9,17,20].…”

Section: Introductionmentioning

confidence: 99%

“…All these methods have been widely studied to prepare hybrid hydrogel-silica nanocomposites. Polymer-silica hybrids have been obtained by using homopolymer and copolymer networks based in hydroxyethylmethacrylate (HEMA) and hydroxyethylacrylate (HEA) being polymerized simultaneously by sol-gel synthesis of the silica network [12][13][14]19,21,22].…”

Section: Introductionmentioning

confidence: 99%

Silica phase formed by sol–gel reaction in the nano- and micro-pores of a polymer hydrogel

Bonilla¹,

Gómez-Tejedor²,

Perilla³

et al. 2013

Journal of Non-Crystalline Solids

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ElsevierPlazas Bonilla, CE.; Gómez-Tejedor, JA.; Perilla, JE.; Gómez Ribelles, JL. (2013). Silica phase formed by sol-gel reaction in the nano-and micro-pores of a polymer hydrogel. Journal of Non-Crystalline Solids. 379:12-20. doi:10.1016/j.jnoncrysol.2013. Corresponding author José L. Gómez Ribelles .E-mail address: jlgomez@ter.upv.es AbstractHybrid composites consisting in a hydrogel matrix with silica micro-and nano-particles reinforcement were produced and characterized. The strategy proposed in this work to obtain these composites consisted in a two-step synthesis, being the polymer network formation the first step. Porous poly(hydroxyethyl acrylate) polymer network was produced via free radical polymerization. Monomer and crosslinker were diluted in a varying amount of ethanol that controls the porosity of the resulting network. Polymeric microstructure drives the absorption of a silica precursor solution and the further distribution of the inorganic phase which was formed "in situ" in part occupying the pores and in part in the form of nanoparticles distributed in the polymer phase.Composites with silica content up to 60% by weight were obtained. In the case where the silica phase was continuous, samples maintained their integrity after eliminating the organic phase by pyrolysis. Water absorbed in the gel was able to crystallize, at least in Clara E. Plazas Bonilla, Journal of Non-Crystaline Solids 379 (2013) 12-20 2 part, when the silica content was below 30% by weight. Interestingly, for higher silica content the glass transition of the polymer phase was suppressed as well. Compliance was determined by indentation experiments. A continuous decrease in compliance was observed as filler content increased. Improvement of bioactivity of the material in simulated body fluid was also assessed. The synthetic route proposed allowed obtaining a family of composite hydrogels with variable properties. HighlightsA procedure to synthesize an interconnected silica nanophase in a previously formed polymer hydrogel.Silica nano-and micro-domains formed in a polymer nano-and micro-porous hydrogel by a sol-gel reaction.Hybrid materials with up to 60% by weight silica content in which both silica and organic phases are continuous.

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Synthesis and characterization of nanoporous SiO2/pHEMA biocomposites

Cited by 16 publications

References 30 publications

Hybrid Ti‐ceramic bionanomaterials for medical engineering

Hybrid Ti‐ceramic bionanomaterials for medical engineering

Development of biodegradable scaffolds for tissue engineering: A perspective on emerging technology

Silica phase formed by sol–gel reaction in the nano- and micro-pores of a polymer hydrogel

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