Synthesis and characterization of multifunctional magnetic polyvinyl alcohol (PVA) microspheres for embolization of blood vessel

Qiu, Shuang; Ge, Nai J.; Sun, Dong; Zhao, Sheng; Sun, J.; Guo, Zhao; Hu, Ke; Gu, Ning

doi:10.1109/tbme.2015.2469735

Cited by 13 publications

(12 citation statements)

References 18 publications

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“…In medicine, PVA is convenient because it has low protein absorption and chemical resistance [121]. Thus, it has been used for applications such as controlled drug delivery systems [106], soft contact lenses [96,106], eye drops [122], embolization particles [123,124], tissue adhesion barriers [125,126], transdermal patches and jellies for the skin [115], and as artificial cartilage and meniscus [106,127]. Moreover, PVA helps dissipate heat and prolongs electronic devices' lifetime [128], is helpful for wastewater treatment [129][130][131][132], as well as in the industrial, commercial, and food sectors [106,[133][134][135][136][137][138][139][140].…”

Section: Usesmentioning

confidence: 99%

Non-Ionic Surfactants for Stabilization of Polymeric Nanoparticles for Biomedical Uses

et al. 2021

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Surfactants are essential in the manufacture of polymeric nanoparticles by emulsion formation methods and to preserve the stability of carriers in liquid media. The deposition of non-ionic surfactants at the interface allows a considerable reduction of the globule of the emulsion with high biocompatibility and the possibility of oscillating the final sizes in a wide nanometric range. Therefore, this review presents an analysis of the three principal non-ionic surfactants utilized in the manufacture of polymeric nanoparticles; polysorbates, poly(vinyl alcohol), and poloxamers. We included a section on general properties and uses and a comprehensive compilation of formulations with each principal non-ionic surfactant. Then, we highlight a section on the interaction of non-ionic surfactants with biological barriers to emphasize that the function of surfactants is not limited to stabilizing the dispersion of nanoparticles and has a broad impact on pharmacokinetics. Finally, the last section corresponds to a recommendation in the experimental approach for choosing a surfactant applying the systematic methodology of Quality by Design.

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Section: Usesmentioning

confidence: 99%

Non-Ionic Surfactants for Stabilization of Polymeric Nanoparticles for Biomedical Uses

et al. 2021

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“…Poly(vinyl alcohol) (PVA) has good biocompatibility , and elasticity, so it is the most commonly used material for fabricating embolic microspheres. − Currently, the methods for fabricating PVA microspheres mainly include emulsification, followed by chemical cross-linking, ,, spray drying, , freezing–thawing, , and microfluidic technology. − For example, Li et al dispersed PVA aqueous solution into the mixed solution of Span 80 and n -heptane by stirring to form water-in-oil droplets and then added glutaraldehyde (GA) as a chemical cross-linking agent to prepare PVA microspheres . Avcioglu et al prepared PVA powder particles by the spray drying method .…”

Section: Introductionmentioning

confidence: 99%

Controllable Fabrication of Monodisperse Poly(vinyl alcohol) Microspheres with Droplet Microfluidics for Embolization

Yang

Deng

et al. 2022

Ind. Eng. Chem. Res.

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A novel strategy based on droplet microfluidics is developed for facile fabrication of monodisperse poly(vinyl alcohol) (PVA) microspheres with controllable sizes and elastic properties for embolization. Monodisperse emulsion droplets are fabricated as templates by dissolving PVA and boric acid in the aqueous disperse phase, and chemical cross-linking between PVA and boric acid inside droplet templates is triggered by adding NaOH into the downstream receiving solution. The cross-linking speed and degree between PVA and boric acid inside droplet templates can be controlled by adjusting the NaOH concentration, height, and rotating speed of the receiving solution. The sizes of droplet templates and resultant cross-linked PVA microspheres can be precisely controlled by adjusting the characteristic dimensions of the microfluidic device as well as the flow rates of disperse and continuous phases. Moreover, the elastic, swelling, and drug-loading properties of PVA microspheres can be controllably regulated by adjusting the ratio of PVA to boric acid in the disperse phase. With an in vitro chip, excellent embolization performances of the fabricated PVA microspheres are visually demonstrated. The proposed strategy provides a facile and efficient route for fabricating monodisperse PVA microspheres with a controllable size and elastic, swelling, drug-loading, and drug-release properties, which are highly desired for applications in embolization therapy.

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“…12 Currently, a wide variety of functional polyvinyl alcohol embolization microspheres have been reported. These include CT/MR imaging capability, [13][14][15][16] tissue adhesion, 13 magnetic responsiveness and magneto-thermal properties, 17 and so forth. Unfortunately, Unfortunately, PVA embolic microspheres have good hydrophilicity, which is not helpful for hydrophobic drug loading.…”

Section: Introductionmentioning

confidence: 99%

Amphiphilic drug slow release microspheres fabricated using polyvinyl alcohol, 10‐Undecen‐1‐ol, and multi‐walled carbon nanotubes

Tian

Liu

Yang

et al. 2022

J of Applied Polymer Sci

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In this paper, novel embolic microspheres with efficient drug delivery and slow drug release properties were developed, which have potential applications in transarterial chemoembolization (TACE). The microspheres were prepared by suspension polymerization using vinyl acetate, 10-Undecen-1-ol (UO), multiwalled carbon nanotubes, and crosslinking agent (1,4-butanediol divinyl ether). In the process, porous titanium tubes are used to control the particle size of the microspheres. In addition, the introduction of long-chain (UO) makes the microsphere good swelling property in acetone. Multi-walled carbon nanotubes modified by hexadecyltrimethoxysilane (HDTMS) are helpful for increasing both spherical morphology stabilization and swelling properties in acetone as well (C-PVA-2UO/CNT). Target drug was dissolved in acetone and the mcirospheres were dispersed in acetone to realize drug load. In vitro biocompatibility analysis showed that C-PVA-2UO/CNT is noncytotoxic and hemocompatible. The sustained drug release properties of C-PVA-2UO/CNT were confirmed by drug indomethacin (IMC) loading and release experiments. These findings suggest that the newly developed C-PVA-2UO/CNT has great potential to be used as a drug-loaded embolization agent.

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Synthesis and characterization of multifunctional magnetic polyvinyl alcohol (PVA) microspheres for embolization of blood vessel

Abstract: The magnetic hydrogel microspheres exhibited the specific fluidity-like iodized oil, but were able to form solid embolus. Because of the advantages of this novel material, it is expected to get extensive application in the clinic embolotherapy.

Cited by 13 publications

References 18 publications

Non-Ionic Surfactants for Stabilization of Polymeric Nanoparticles for Biomedical Uses

Non-Ionic Surfactants for Stabilization of Polymeric Nanoparticles for Biomedical Uses

Controllable Fabrication of Monodisperse Poly(vinyl alcohol) Microspheres with Droplet Microfluidics for Embolization

Amphiphilic drug slow release microspheres fabricated using polyvinyl alcohol, 10‐Undecen‐1‐ol, and multi‐walled carbon nanotubes

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