Synthesis and characterization of monosodium urate (MSU) nano particles

Abstract

In Gout the deposition of crystals of Monosodium Urate monohydrate (MSUM) in various connective tissues and joints occurs, which is very painful with immflamation.The deposition likely to begin with nano particles form and expected to grow in to micro-paricles and hence it is important to synthesize and characrterize MSU nano-particles. The MSU nano particles were synthesized by wet chemical method using NaOH and uric acid (C5H4N4O3) and then characterized by powder XRD, TEM, FT-IR and thermal analysis. From the powder XRD the triclinic structure was found and 40 nm average particle size was estimated by using Scherrer's formula. From TEM the particle size was found to be in the range of 20 to 60 nm. The FT-IR spectrum for the MSU nano particles confirmed the presence of O-H stretching, N-H stretching, N-H rocking, C = O, C = C Enol or Keto and C = N vibrations. The thermal analysis was carried out from room temperature to 900ºC. With comparison to the bulk MSU the thermal stability of MSU nano particles was slightly higher and 1.5 water molecules were found to be associated with MSU nano particals. Present results are compared with the bulk MSU.

Structure and cleavage of monosodium urate monohydrate crystals

“…MSU crystals were prepared according to an established method. 3 50 cm 3 sodium hydroxide (0.2 M) was heated to 70°C. Uric acid (1.67 g, 9.93 mmol) was added in small portions and the solution was stirred for 4 h. A white opaque powder precipitate was recovered by filtrating, washing with distilled water, and drying at 60°C.…”

Electrophoretically Deposited p-Phenylene Diamine Reduced Graphene Oxide Ultrathin Film on LiNi0.5Mn1.5O4 Cathode to Improve the Cycle Performance

“…Peaks at 3408, 1726, 1622, 1221, and 1051 cm –1 in the spectrum of GO film are from H 2 O, carboxyl CO, aromatic CC, epoxy C–O, alkoxyl C–O, respectively . The FTIR spectrum of the p PD–rGO film presents three new peaks at 823, 1165, and 1508 cm –1 , originating from N–H rocking, C–N stretching vibrations, and C–N and N–H bending vibrations, respectively. During the preparation of the p PD–rGO suspension, the reaction between p PD molecules and GO nanosheets generated C–N groups.…”

Aqueous and Methanol Extracts of Paullinia pinnata (Sapindaceae) Improve Monosodium Urate-Induced Gouty Arthritis in Rat: Analgesic, Anti-Inflammatory, and Antioxidant Effects

“…MSU crystals were synthesized according to a modified protocol of Tank et al [17]. Two-hundred milliliters of an aqueous solution of NaOH (1 M) was stirred well and heated up to 70°C.…”