Synthesis and Characterization of Molecularly Imprinted Polymers of Di-(2-Ethylhexyl) Phthalate Using The Precipitation Polymerization Method

Abstract

Molecularly Imprinted Polymers (MIP) is a synthetic functional material that can recognize target molecules selectively. This study aims to synthesize and characterize MIP and its performance by precipitation polymerization method using methacrylic acid (MAA), ethylene glycol dimethacrylate (EGDMA), and di-(2-Ethylhexyl) phthalate (DEHP). Characterization of MIP was conducted by FTIR, SEM-EDS, SAA, and UV-Vis spectrophotometer. The effect of concentration and time on MIP adsorption ability against DEHP was also determined. SEM shows that MIP_DEHP_MAA-co-EGDMA surface morphology is arranged from more uniform, less tight, and more fine granules than NIP_MAA-co-EGDMA. FTIR characterization of MIP and NIP (Non-Imprinted Polymers) shows absorption bands of functional groups were -OH, C-H, C=O, and -C=C. SAA characterization shows MIP surface area is 137.660 m 2 /g, total pore volume 0.1555 cc/g, and an average pore radius 22.59 Å that indicates as mesopore material. MIP_DEHP_MAA-co-EGDMA (AE) adsorbed DEHP better than NIP_MAA-co-EGDMA. The difference value of the adsorbed DEHP (qe) was 0.212 mg/g.

Bio‐Inspired Imprinting Materials for Biomedical Applications

“…Precipitation polymerization is another promising polymerization method to produce MIP particles with more spherical surfaces and uniform sizes. [ 96 , 97 , 98 ] In the precipitation system, the growing polymer chains are insoluble with monomers, or monomer and initiators are soluble with the medium while the polymer chains are not soluble, both of which eventually lead to the precipitation of formed polymer out of the reaction system. Then the polymers undergo washing and centrifugation operations to obtain resultant MIPs.…”

Purification of Andrographolide Methanolic Extract Using Molecularly Imprinted Polymer Prepared by Precipitation Polymerization

“…Spherical and monodisperse particle shapes will produce a good separation profile. In addition, precipitation polymerization can prevent the destruction of particles due to grinding and filtering, which is usually performed in bulk polymerization [13]. This method begins with a homogenous system that becomes heterogeneous in the continuous phase.…”

“…Precipitation polymerization involves homogeneous nucleation in MIP particles formation. Initially, all components were mixed, while the critical chain lengths insoluble in the continuous phase were grown after polymerization to form particles and precipitate [7,[11][12][13][14][15][16].…”

“…Precip tation polymerization involves homogeneous nucleation in MIP particles formation. In tially, all components were mixed, while the critical chain lengths insoluble in the contin uous phase were grown after polymerization to form particles and precipitate [7,[11][12][13][14][15][16] MIP has been used in several fields, such as drug delivery with specific targets [16-20 separation of related molecules and food adulterants in chromatography, industri safety, and environmental analysis or separation [16,21,22]. It is also employed in the pu rification of biological, chemical reagents, and natural products [16,[23][24][25][26][27]; therefore, i this study, MIP prepared using andrographolide as a template molecule was used for th purification.…”