Synthesis and characterization of MFI-type borosilicate zeolites and evaluation of their efficiency as drug delivery systems

Khatamian, M.; Yavari, A.; Akbarzadeh, A.

doi:10.1016/j.msec.2017.03.008

Cited by 16 publications

(5 citation statements)

References 41 publications

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“…The clinoptilolite/graphene oxide composite demonstrated a high doxorubicin-loading capacity and increased cytotoxicity against in vitro lung cancer cells, thus demonstrating improved effectiveness. The efficiency of MFI-type borosilicate zeolites as DDS for doxorubicin was also reported [ 104 ]. In this system, it is worth mentioning that the drug-loading efficiency was greatly influenced by the borosilicate particle size, the organization of the zeolite nanocrystals, and the external surface area of MFI borosilicate.…”

Section: Zeolites As Drug Delivery Systemsmentioning

confidence: 99%

“…In this system, it is worth mentioning that the drug-loading efficiency was greatly influenced by the borosilicate particle size, the organization of the zeolite nanocrystals, and the external surface area of MFI borosilicate. Moreover, the in vitro release of doxorubicin from the MFI borosilicate particles proved to be pH dependent, with a higher drug release rate in low pH environments [ 104 ]. This pH-dependent release of MDDS has already been mentioned elsewhere in this manuscript as a good strategy to control the release of certain drugs along the gastrointestinal tract.…”

Section: Zeolites As Drug Delivery Systemsmentioning

confidence: 99%

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Zeolites as Ingredients of Medicinal Products

et al. 2023

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Development of new medicinal products for particular therapeutic treatment or for better manipulations with better quality and less side effects are possible as a result of advanced inorganic and organic materials application, among which zeolites, due to their properties and versatility, have been gaining attention. This paper is an overview of the development in the use of zeolite materials and their composites and modifications as medicinal products for several purposes such as active agents, carriers, for topical treatments, oral formulations, anticancer, the composition of theragnostic systems, vaccines, parenteral dosage forms, tissue engineering, etc. The objective of this review is to explore the main properties of zeolites and associate them with their drug interaction, mainly addressing the advances and studies related to the use of zeolites for different types of treatments due to their zeolite characteristics such as molecule storage capacity, physical and chemical stability, cation exchange capacity, and possibility of functionalization. The use of computational tools to predict the drug—zeolite interaction is also explored. As conclusion was possible to realize the possibilities and versatility of zeolite applications as being able to act in several aspects of medicinal products.

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Section: Zeolites As Drug Delivery Systemsmentioning

confidence: 99%

Section: Zeolites As Drug Delivery Systemsmentioning

confidence: 99%

Zeolites as Ingredients of Medicinal Products

et al. 2023

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“…Zeolites, i.e., crystalline aluminosilicates, which are now widely used in various fields of industry, seem to be attractive materials for biomedical and tissue engineering applications. Examples of these applications include haemostatics [7], carriers for drug delivery [8,9], substrates for protein immobilization [10], substrates for incorporating metallic ions with antibacterial properties [11], and, particularly, bone implant coatings [12]. Various applications of zeolites, including applications with biomedical perspectives, have been summarized in recent reviews [13,14].…”

Section: Introductionmentioning

confidence: 99%

Silicalite-1 Layers as a Biocompatible Nano- and Micro-Structured Coating: An In Vitro Study on MG-63 Cells

et al. 2019

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Silicalite-1 is a purely siliceous form of zeolite, which does not contain potentially harmful aluminum in its structure as opposed to ZSM-5 aluminosilicate types of zeolite. This paper reports on a study of a silicalite-1 film, deposited on a silicon Si(100) substrate, as a potential anti-corrosive and biocompatible coating for orthopaedic implants. Silicalite-1 film was prepared in situ on the surface of Si(100) wafers using a reaction mixture of tetrapropyl-ammonium hydroxide (TPAOH), tetraethyl-orthosilicate (TEOS), and diH2O. The physico-chemical properties of the obtained surface were characterized by means of X-ray photoelectron spectroscopy, water contact angle measurement, atomic force microscopy, and scanning electron microscopy. The biocompatibility was assessed by interaction with the MG-63 cell line (human osteosarcoma) in terms of cell adhesion, morphology, proliferation, and viability. The synthesized silicalite-1 film consisted of two layers (b- and a, b-oriented crystals) creating a combination of micro- and nano-scale surface morphology suitable for cell growth. Despite its hydrophobicity, the silicalite-1 film increased the number of initially adhered human osteoblast-like MG-63 cells and the proliferation rate of these cells. The silicalite-1 film also improved the cell viability in comparison with the reference Si(100) substrate. It is therefore a promising candidate for coating of orthopaedic implants.

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“…Where k is the dimensionless form factor (usually 0.94 for zeolites), D is the size of the crystallite in nm, λ is the wavelength of radiation of X-ray in CuKα, β is the full width at half maximum (FWHM) of the diffraction peak and θ is the angle of the peak in the XRD pattern, the most characteristic peak of crystalline phase of faujasite zeolite considered to obtain the crystallite size estimations was the peak at 6.8(2θ angle) [30]. Fourier transform infrared (FTIR) spectroscopy to identify the functional groups present on the surface of the zeolites was carried out.…”

Section: D=kλˑ(βcosθ) -1mentioning

confidence: 99%