Synthesis and Characterization of (Methyl Methacrylate/Phenyl Acrylamide) Hydrogel for Biomedical Applications

Abstract

The basic explorations of structure property correlations and the variety of commercial and biological applications all attest to the fact that amphiphilic is highly useful. In this work, the monomer phenyl acrylamide was synthesized by reacting acrylamide with chloro benzene in the presence of pyridine. Two series of Poly (phenyl acrylamide-co-methyl methacrylate) (poly(PAAm-co-MMA)) hydrogels have been prepared, series 1 composed of PAAm/MMA copolymers covering a range of composition (60-90% PAAm) while series 2 composed of 90PAAm/10MMA copolymer containing 1, 2, 3, and 4 wt% of N,N'-methylenebisacrylamide (MBAA) as crosslinker. Fourier transform infrared spectroscopy (FT-IR) was used to characterize the resulting monomer and polymers. The effects of the monomer ratio and added crosslinker on the swelling behavior and mechanical properties of poly (PAAm-co-MMA) hydrogels were investigated. Swelling parameters such as volume fraction of polymer (φ2), weight loss during swelling were determined. Depending on shear and Young's modulus (G and E), network parameters such as polymer-solvent interaction (χ), cross-link density (ve), and molecular mass between cross-links (Mc) were calculated. The ability of series 1 hydrogels for use in controlled release of drugs such as ciprofloxacin was also studied. Results revealed that during the first 10 hours, most of the drug load is released.

Crosslinked poly(hydroxybutyl acrylate-co-acrylamide) based hydrogels: synthesis, characterization, and performance evaluation in heavy metal removal

“…Crosslinked hydrogels prepared from different hydrophilic monomers have been widely utilized in different fields, including contact lenses, drug delivery, diagnostics, pharmaceutical, wound dressing, gene delivery, agriculture, thermo sensitive materials, and food industry [6][7][8][9]. Among them, hydrogels prepared from acrylamide derivatives have been used in various fields such as linear polymers, tissue engineering, film making, smart polymers, heavy metal removal, and dye removal [10][11][12][13][14][15].…”

Synthesis of Multifunctional Polymers Based on Tert-Butyl Acrylamide/Octyl Acrylate as Lubricant Additives and Adsorbents for Copper Ion from Aqueous Solution

“…By using the standard corrosion testing method, the anticorrosion activity of the potential polymeric additions was examined 25,26 . The steel metal was initially cut and machined into small pieces that measured 30mm×20mm×4mm (area: 2.4 square inches).…”

Synthesis and characterization of modified PVC waste with different diamines for Hg(II) removal

“…On the other hand, the huge production, and uses of plastic polymers such as PVC and polyethylene cause many environmental problems due to their durability [6,7]. To reduce the problems caused by these pollutants, polymers waste should be recycled to useful materials that can be employed in many applications, such as oil/water separation, heavy metals removal, construction and building, drug delivery release, and gases separation [8][9][10][11]. To ensure the success of using PVC waste as heavy metals removal, its chemical structure should be modified by introducing functional groups containing high electron density atoms such as oxygen and nitrogen due to the ability of such atoms to form strong coordination bonds with heavy metals ions [12].…”