Synthesis and characterization of mesoporous SBA-15 and SBA-16 as carriers to improve albendazole dissolution rate

Abstract

Albendazole (ABZ, anti-parasitic active pharmaceutical ingredient) is a crystalline low water-soluble drug, thus the dissolution rate in gastrointestinal fluids is limited. Consequently, the improvement of the water solubility and dissolution rate of ABZ implies a great challenge for a more efficient treatment of hydatidosis. In this context, SBA-15 and SBA-16 ordered mesoporous silica materials were synthetized and loaded with ABZ. X-ray diffraction, FT-IR spectroscopy, nitrogen physisorption manometry, particle size distribution and scanning electronic microscopy were used to characterize unloaded and loaded materials (ABZ/SBA-15 and ABZ/SBA-16). The loaded ABZ amount in the carriers was estimated by elemental analysis. For the loaded materials, the drug solubility and release profile were evaluated. In addition, mathematical models were compared to explain the dissolution kinetics of ABZ from mesoporous solids. ABZ was successfully loaded into the mesopores. The amorphous state of the adsorbed ABZ was confirmed by differential scanning calorimetry that resulted in a notable increment in the dissolution rate compared to crystalline ABZ. Drug release behaviors were well simulated by the Weibull model for ABZ/SBA-15 and by the Gompertz function for pure ABZ and ABZ/SBA-16. The SBA-15 carrier exhibited the highest drug loading and dissolution rate becoming a promising material to improve ABZ bioavailability.

Antibacterial Effect of Thymol Loaded SBA-15 Nanorods Incorporated in PCL Electrospun Fibers

“…Hu et al [8] found that SBA-16-based 3D continuous and interconnected porous particles can reduce the diffusion resistance and facilitate transport of drugs compare to 2D cylindrical channel materials such as MCM-41. However, SBA-15 had shown higher drug loading ability than SBA-16 [9]. Two-dimensional hexagonal structured SBA-15, one of the most important types of mesoporous silicas, has large pore sizes (5-30 nm), an ordered structure, and surface silanol groups that can facilitate intermolecular hydrogen bonding with different drugs promoting their bioavailability, which is especially important for highly hydrophobic drugs; in addition, pore-mouth functionalization can avoid a premature drug release by means of molecular gates [10].…”

Solid Polymeric Nanoparticles of Albendazole: Synthesis, Physico-Chemical Characterization and Biological Activity

“…The located between 1222.87 and 958.62 correspond to CH and NH in-plane bending vibrati -deformation. The last region of bands, 923.90-597.93 cm −1 consist in skeletal vibrations, plane bending, NH2 rocking and C-S stretching vibrations [22][23][24][25]. e main characteristic bands observed in the pure PU spectrum were assigned as follows: haracteristic band at 3500-3250 cm −1 with a peak at around 3346; the C-H band at 3000-2 ith a peak at around 2873, and the band corresponding to the fingerprint region, at 750-1…”

“…The five bands located between 1222.87 and 958.62 correspond to CH and NH in-plane bending vibrations and CHdeformation. The last region of bands, 923.90-597.93 cm −1 consist in skeletal vibrations, CH out of plane bending, NH 2 rocking and C-S stretching vibrations[22][23][24][25].…”

Intra-articular delivery of celastrol by hollow mesoporous silica nanoparticles for pH-sensitive anti-inflammatory therapy against knee osteoarthritis

“…HMSNs are excellent candidates for loading traditional medicine facing the issue of their poor solubility. The ability to improve bioavailability has been demonstrated in many drugs with poor solubilities such as resveratrol and albendazole [ 28 , 29 ]. The high volume of pores provides a large contact area to the vehicle solution, leading to better drug loading and release.…”