Synthesis and characterization of mesoporous Gd2O3 nanotube and its use as a drug-carrying vehicle

Chang, Yu‐Min; Liu, Kun-Ho; Chao, Chih-Shin; Chen, San‐Yuan; LIu, Dean-Mo

doi:10.1016/j.actbio.2010.03.009

Cited by 13 publications

(12 citation statements)

References 22 publications

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“…colloidal and combustion methods [9,10], Chang et al [11] reported on the preparation of a mesoporous Gd 2 O 3 network with a tubular nanostructure by using a combination of soft template and sol-gel methods. In general, liquid based synthesis methods usually require careful control of reaction parameters such as pH, temperature, and concentration of reactants in order to obtain the desired particle size and morphology.…”

Section: Introductionmentioning

confidence: 99%

Growth of Gd2O3 nanoparticles inside mesoporous silica frameworks

Ballem

Söderlind

Nordblad

et al. 2013

Microporous and Mesoporous Materials

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Gadolinium oxide (Gd 2 O 3 ) nanoparticles with very small size and narrow size distribution were synthesized by infiltration of Gd(NO 3 ) 3 ·6H 2 O as an oxide precursor into the pores of SBA-15 mesoporous silica using a wet-impregnation technique. High resolution transmission electron microscopy and X-ray diffraction show that during the hydrothermal treatment of the precursor at 550 °C, gadolinium oxide nanoparticles inside the silica pores are formed. Subsequent dissolution of the silica framework in aqueous NaOH resulted in well dispersed nanoparticles with an average diameter of 3.6 ± 0.9 nm. If GdCl 3 ·6H 2 O is used as precursor, GdOCl is formed instead of Gd 2 O 3 . The Gd 2 O 3 nanoparticles showed a weak antiferromagnetic behaviour, as expected.

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Section: Introductionmentioning

confidence: 99%

Growth of Gd2O3 nanoparticles inside mesoporous silica frameworks

Ballem

Söderlind

Nordblad

et al. 2013

Microporous and Mesoporous Materials

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“…The absorption appearing around 1,510 and 1,410 cm −1 corresponds to CO asymmetric vibration. The band at 540 cm −1 is assigned to the Gd-O vibration mode of the cubic Gd 2 O 3 [3]. Also, we know that the peaks at 800 to 1,400 are assigned to CdO [35].…”

Section: Powder Xrd Analysismentioning

confidence: 99%

“…Pure CdO cell parameters calculated as a = 0.46941 nm and for doped CdO (in x = 0.08 mmole) were a = 0.46912 nm. The calculations showed that the unit cell volume of pure CdO is 0.1034 nm 3 and that of the doped CdO is 0.10324 nm 3 . So, we can conclude that there is a contraction in the unit cell when doping Gd 3+ in CdO.…”

Section: Powder Xrd Analysismentioning

confidence: 99%

“…Gadolinium oxide (Gd 2 O 3 ) has been frequently used as host material due to abundant resource in nature. Further, Gd is a known contrast agent for magnetic resonance imaging (MRI), and thus the rare-earth ion-doped Gd 2 O 3 can be used in dual, MRI, and fluorescence imaging applications [2] and as a drug carrier [3]. In addition, pure and doped Gd 2 O 3 films have been studied as high dielectric constant gate dielectric films, phosphor films, and scintillating films [4,5].…”

Section: Introductionmentioning

confidence: 99%

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Sol–gel synthesis, characterization, and optical properties of Gd3+-doped CdO sub-micron materials

et al. 2013

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Highly crystalline Gd 3+ -doped cadmium oxide micro-structure was synthesized by calcining the obtained precursor of a sol-gel reaction. The reaction was carried out with cadmium nitrate (Cd(NO 3 ) 2 ·4H 2 O), gadolinium oxide, and ethylene glycol (C 2 H 6 O 2 ) reactants without any additives at 80°C for 2 h. The resulting gel was calcined at 900°C with increasing temperature rate of 15°C/min for 12 h in a furnace. As a result of heating, the organic section of the gel was removed, and the Gd 3+ -doped cadmium oxide micro-structure was produced. The obtained compound from the sol-gel technique possesses a cubic crystalline structure at a micro scale. XRD study indicates that the obtained Gd 3+-doped CdO has a cubic phase. Also, the SEM images showed that the resulting material is composed of particles with cluster structure. Also, FT-IR spectroscopy was employed to characterize the Gd 3+ -doped CdO micro-structures.

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“…Therefore, they are chelated to form a stable compound and thereby reduce the toxicity levels. 9 There are various methods to synthesize the gadolinium oxide nanoparticles such as polyol method, 10 co-precipitation method, 11 hydrothermal method, 12 sol-gel method, 13 template-assisted technique, 14 pulsed laser ablation, 15 pulsed electron beam evaporation 16 and mechano-chemical methods. 17 Di®erent morphologies of gadolinium oxide nanoparticles such as nanospheres, 18 nano¯bers, 19 nanotubes/ nanorods 20 and nanoplates 21 can be prepared by controlling the process parameters.…”

Section: Introductionmentioning

confidence: 99%

Silica-Coated Europium-Doped Gadolinium Oxide Nanorods for Dual-Modal Imaging of Cancer Cells

Gayathri

Kumar

Panigrahi

et al. 2017

NANO

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Dual-modal imaging of cancer cells is possible with the silica-coated europium-doped gadolinium oxide nanorods due to their magnetic and luminescent properties. In the synthesized nanorods, europium ions serve as`luminescent centers' facilitating optical imaging and gadolinium oxide acts as the contrast agent for magnetic resonance imaging (MRI). This article reports the synthesis method of the europium-doped gadolinium oxide (Eu:Gd 2 O 3 Þ nanorods by the co-precipitation method. The prepared nanorods are further coated with silica to improve its biocompatibility. From the x-ray di®raction (XRD) data, the crystallinity was found to decrease due to the amorphous nature of the silica. Transmission electron microscopy (TEM) studies show that Eu:Gd 2 O 3 nanorods with a length of $ 600 nm and diameter of $ 40 nm were formed. Silica was coated uniformly with the thickness of $ 15 nm. Fourier transform infrared spectroscopy (FTIR) con¯rms the presence of silica in the prepared nanorods. Emission at 611 nm due the presence of Eu 3þ ions was observed. The life time of uncoated and silica-coated nanorods was calculated to be 1.1 ms and 0.9 ms, respectively. In vitro cytotoxicity of the synthesized nanorods in MG63 (human osteosarcoma cell line) was assessed by MTT assay. In vitro MRI studies reveal that the prepared nanorods can be used for T 1 contrast enhancement.

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Synthesis and characterization of mesoporous Gd2O3 nanotube and its use as a drug-carrying vehicle

Cited by 13 publications

References 22 publications

Growth of Gd2O3 nanoparticles inside mesoporous silica frameworks

Growth of Gd2O3 nanoparticles inside mesoporous silica frameworks

Sol–gel synthesis, characterization, and optical properties of Gd3+-doped CdO sub-micron materials

Silica-Coated Europium-Doped Gadolinium Oxide Nanorods for Dual-Modal Imaging of Cancer Cells

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