Synthesis and Characterization of Iodixanol

Priebe, H.; Dugstad, Harald; Gacek, Matthew; Hagen, Edward H.; Homestad, O. M.; Larsen, Åsmund; Sjøgren, C. E.; Thomassen, Terje

doi:10.1177/0284185195036s39903

Cited by 13 publications

(11 citation statements)

References 5 publications

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“…During the production process (7, 8) and pharmaceutical processing, iodixanol like any drug substance may be exposed to acid, base, air, heat and daylight. Whether iodixanol is stable under such conditions had to be investigated.…”

Section: Introductionmentioning

confidence: 99%

Stability of the X-ray contrast agent iodixanol=3,3',5,5'-tetrakis(2,3-dihydroxypropylcarbamoyl)-2,2',4,4',6,6'-hexaiodo-N,N'-(2-hydroxypropane-1,3-diyl)-diacetanilide towards acid, base, oxygen, heat and light

Priebe¹,

Aukrust²,

Bjørsvik

et al. 1999

J Clin Pharm Ther

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Section: Introductionmentioning

confidence: 99%

Stability of the X-ray contrast agent iodixanol=3,3',5,5'-tetrakis(2,3-dihydroxypropylcarbamoyl)-2,2',4,4',6,6'-hexaiodo-N,N'-(2-hydroxypropane-1,3-diyl)-diacetanilide towards acid, base, oxygen, heat and light

Priebe¹,

Aukrust²,

Bjørsvik

et al. 1999

J Clin Pharm Ther

Self Cite

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show abstract

“…2h ). Iodixanol shows a similar spectrum to protein from 2800 to 3150 cm −1 , but has a quite different spectrum profile in the fingerprint region where there is a unique vibrational peak at 1523 cm −1 contributed by the aromatic ring as well as the secondary amide II band in its molecular structure 64 . By sweeping the SRS spectrum of the LF layer immersed in Iodixanol, we found a small SRS peak at 1523 cm −1 that disappeared when Iodixanol was rinsed out (Fig.…”

Section: Resultsmentioning

confidence: 98%

Long-term in vivo imaging of mouse spinal cord through an optically cleared intervertebral window

et al. 2022

Nat Commun

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The spinal cord accounts for the main communication pathway between the brain and the peripheral nervous system. Spinal cord injury is a devastating and largely irreversible neurological trauma, and can result in lifelong disability and paralysis with no available cure. In vivo spinal cord imaging in mouse models without introducing immunological artifacts is critical to understand spinal cord pathology and discover effective treatments. We developed a minimally invasive intervertebral window by retaining the ligamentum flavum to protect the underlying spinal cord. By introducing an optical clearing method, we achieve repeated two-photon fluorescence and stimulated Raman scattering imaging at subcellular resolution with up to 15 imaging sessions over 6–167 days and observe no inflammatory response. Using this optically cleared intervertebral window, we study neuron-glia dynamics following laser axotomy and observe strengthened contact of microglia with the nodes of Ranvier during axonal degeneration. By enabling long-term, repetitive, stable, high-resolution and inflammation-free imaging of mouse spinal cord, our method provides a reliable platform in the research aiming at interpretation of spinal cord physiology and pathology.

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“…Considerable ingress of iodixanol was noticed in the EVs after ultracentrifugation (Figure S5, Supporting Information). [ 41 ] We have performed TEM analysis of these layers and a large number of EVs were detected in the first two layers (Size: 180–600 nm), while cell debris were seen in the subsequent layers (Figure S4, Supporting Information). This result reaffirms the production of EVs containing penicillin by P. chrysogenum .…”

Section: Resultsmentioning

confidence: 99%

Raman Microspectroscopy Imaging Analysis of Extracellular Vesicles Biogenesis by Filamentous Fungus Penicilium chrysogenum

et al. 2022

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The mechanism of production of extracellular vesicles (EVs) and their molecular contents are of great interest due to their diverse roles in biological systems and are far from being completely understood. Even though cellular cargo releases mediated by EVs have been demonstrated in several cases, their role in secondary metabolite production and release remains elusive. In this study, this aspect is investigated in detail using Raman microspectroscopic imaging. Considerable evidence is provided to suggest that the release of antibiotic penicillin by the filamentous fungus Penicillium chrysogenum involves EVs. Further, the study also reveals morphological modifications of the fungal body during biogenesis, changes in cell composition at the locus of biogenesis, and major molecular contents of the released EVs. The results suggest a possible general role of EVs in the release of antibiotics from the producing organisms.

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Synthesis and Characterization of Iodixanol

Cited by 13 publications

References 5 publications

Stability of the X-ray contrast agent iodixanol=3,3',5,5'-tetrakis(2,3-dihydroxypropylcarbamoyl)-2,2',4,4',6,6'-hexaiodo-N,N'-(2-hydroxypropane-1,3-diyl)-diacetanilide towards acid, base, oxygen, heat and light

Stability of the X-ray contrast agent iodixanol=3,3',5,5'-tetrakis(2,3-dihydroxypropylcarbamoyl)-2,2',4,4',6,6'-hexaiodo-N,N'-(2-hydroxypropane-1,3-diyl)-diacetanilide towards acid, base, oxygen, heat and light

Long-term in vivo imaging of mouse spinal cord through an optically cleared intervertebral window

Raman Microspectroscopy Imaging Analysis of Extracellular Vesicles Biogenesis by Filamentous Fungus Penicilium chrysogenum

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