Synthesis and characterization of impurities of Apixaban drug substance—An anticoagulant

Abstract

Apixaban is an anticoagulant used to treat venous thromboembolic disorders. The present work describes the origin and synthesis of related substances of Apixaban PG ester‐1 and PG ester‐2. These impurities arise in the process of Apixaban drug substance, later these impurities are transformed into the final Apixaban drug substance. These novel synthesized impurities were characterized by 1H NMR, 13C NMR, HPLC, and HRMS analysis.