Synthesis and Characterization ofN-glucosylated 1,3,4-Thiadiazolidines

I2/CHP‐Mediated Oxidative Coupling of 2‐Aminobenzamides and Isocyanides: Access to 2‐Aminoquinazolinones

“…On the basis of the above results, a plausible reaction mechanism is shown in Scheme . Isocyanide 2 reacts with iodine by 1,1‐addition to give intermediate I , . The reaction of I with 2‐aminobenzamide 1 gives intermediate II by dehydrohalogenation.…”

“…Therefore, the development of an efficient strategy to construct 2‐amino‐substituted quinazolinones using an inexpensive catalyst under mild conditions is desirable. As reported in the literature, isocyanides could be converted into carbonimidic dihalides through the reaction with Br 2 , Cl 2 , or SO 2 Cl 2 , and these intermediates could then react further with nucleophiles to form heterocycles. Recently, Mirza[11b] reported an efficient synthesis of 2‐amino‐substituted quinazolinones under transition‐metal‐free conditions.…”