Synthesis and characterization of hydroxyapatite-gelatine composite materials for orthopaedic application

Yanovska, Anna; Кузнецов, В. Н.; Stanislavov, A. S.; Husak, Yevheniia; Pogorielov, Мaksym; Стариков, В. В.; Bolshanina, S.; Danilchenko, S. N.

doi:10.1016/j.matchemphys.2016.08.006

Cited by 16 publications

(8 citation statements)

References 37 publications

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“…The mixed addition (Ful and Gel) had a positive effect on the mechanical properties of NCs, with Gel acting as an adhesive material between particles. 17 The increase in Ful content resulted in higher compressive strength: +24.5% (Hap_Gel_Ful_0.5), +23.6% (Hap_Gel_Ful_1.0), and +33.0% (Hap_Gel_Ful_2.0) compared to pure Hap. The results obtained indicate that the positive effect of Gel dominates the negative effect of Ful particles, leading to increasing compressive strength.…”

Section: Compression Testsmentioning

confidence: 96%

“…16 Gel, a product of partial collagen hydrolysis, exhibits attractive properties such as stability, less antigenicity than collagen, plasticity, adhesiveness, low cost, full resorbability in vivo, biocompatibility, and biodegradability, and its physicochemical properties can be suitably modulated. 17 However, the effects of Gel on Hap crystal morphology, mechanical strength, and biocompatibility are still not understood. 14 The Internet of things (IoT) focuses on the interconnection and effective networking of machines and computing devices through the infrastructure of the Internet.…”

Section: Introductionmentioning

confidence: 99%

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Comparative study on physicochemical and mechanical characterization of newnanocarbon-based hydroxyapatite nanocomposites

Barabáş¹,

Deemter²,

Katona³

et al. 2019

Turk J Chem

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This study evaluated the effect of different additives such as nanocarbon compounds (0.5, 1.0, and 2.0 wt.%) with different morphologies and gelatin (Gel) (10 wt.%) on the mechanical properties of hydroxyapatite (Hap)based nanocomposites (NCs). The NCs were prepared using the innovation process "SmartBox" based on the Internet of things (IoT), which provides process control and reproducibility, and they were characterized by X-ray diffraction, particle size distribution, transmission electron microscopy, Fourier transform infrared spectroscopy, and thermal analysis. The compressive strength tests demonstrated that the use of grapheme oxide (Hap_GO_2.0-133 N/mm 2) , and/or Gel (Hap_Gel-152 N/mm 2) as additives to reinforce Hap (106 N/mm 2) is more appropriate than the use of single functionalized multiwalled carbon nanotubes (Hap_fMWCNT_1.0-110 N/mm 2) and fullerene (Hap_Ful_0.5-106 N/mm 2) .

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Section: Compression Testsmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Comparative study on physicochemical and mechanical characterization of newnanocarbon-based hydroxyapatite nanocomposites

Barabáş¹,

Deemter²,

Katona³

et al. 2019

Turk J Chem

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“…Издание подготовлено на кафедре общей физики Тверского государственного университета. В настоящее время при создании остеопластических биоматериалов особое внимание уделяется регенеративному подходу, согласно которому имплантат должен не просто замещать поврежденную костную либо хрящевую ткань, но и способствовать ее полному восстановлению [1][2][3]. В связи с этим значительный интерес представляют кальцийфосфатные цементы [4][5][6], которые в биологических жидкостях постепенно резорбируются с высвобождением ионов кальция и фосфат-ионов, необходимых для образования новой костной ткани.…”

Section: Isbn 978-5-7609-1275-6unclassified

“…Выявлено, что с ростом массовой доли ПВС в материале от 3 По данным адсорбционно-структурного анализа удельная поверхность растертых кальцийфосфатных цементов, содержащих полимеры, значительно выше, чем для образцов с неорганическими компонентами. В частности, для цементов, полученных на основе 35 % суспензии ГА/  ТКФ и порошка ПЭГ либо 10 % раствора ПВС, Межвузовский сборник научных трудов Выпуск 9, 2017…”

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Physical and Chemical Properties of Cement Based on Calcium Phosphate Suspensions

Musskaya¹,

Крутько²,

Кулак³

2017

pcascnn

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“…Hydroxyapatite (HA) is an inorganic component that naturally present in bone tissue and widely used as a main composite for bone tissue regeneration [6]. Bovine hydroxyapatite (BHA) is a natural HA derived from bovine bone.…”

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confidence: 99%

Fabrication and characterization of bovine hydroxyapatite-gelatin-alendronate scaffold cross-linked by glutaraldehyde for bone regeneration

Samirah

Budiatin

Mahyudin

et al. 2021

Journal of Basic and Clinical Physiology and Pharmacology

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Objectives Alendronate are widely used in the treatment of bone disorders characterized by inhibit osteoclast-mediated bone resorption such as Paget’s disease, fibrous dysplasia, myeloma, bone metastases and osteoporosis. In recent studies alendronate improves proliferation and differentiation of osteoblasts, thereby facilitating for bone regeneration. The disadvantages of this class are their poor bioavailability and side effects on oral and intravenous application such as stomach irritation and osteonecrosis in jaw. Thus, local treatment of alendronate is needed in order to achieve high concentration of drug. Bovine hydroxyapatite-gelatin scaffold with alendronate was studied. Glutaraldehyde was used as cross-linking agent, increase the characteristics of this scaffold. The objectives of this study were to manufacture and characterize alendronate scaffold using bovine hydroxyapatite-gelatin and crosslinked by glutaraldehyde. Methods Preparation of cross-linked bovine hydroxyapatite-gelatin and alendronate scaffold with different concentration of glutaraldehyde (0.00, 0.50, 0.75, and 1.00%). The scaffolds were characterized for compressive strength, porosity, density, swelling ratio, in vitro degradation, and cytotoxicity (the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay, shorted as MTT assay). Results Bovine hydroxyapatite-gelatin-alendronate scaffold cross-linked with glutaraldehyde showed lower density than without glutaraldehyde. As glutaraldehyde concentration increased, porosity also increased. Eventually, it reduced compressive strength. Swelling ratio and in vitro degradation was negatively dependent on glutaraldehyde concentration. In addition, the scaffold has a good safety by MTT assay. Conclusions Bovine hydroxyapatite-gelatin-alendronate scaffold was fabricated with various concentrations of glutaraldehyde. The presence of glutaraldehyde on bovine hydroxyapatite-gelatin-alendronate is safe and suitable candidate scaffold for bone regeneration.

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Synthesis and characterization of hydroxyapatite-gelatine composite materials for orthopaedic application

Cited by 16 publications

References 37 publications

Comparative study on physicochemical and mechanical characterization of newnanocarbon-based hydroxyapatite nanocomposites

Comparative study on physicochemical and mechanical characterization of newnanocarbon-based hydroxyapatite nanocomposites

Physical and Chemical Properties of Cement Based on Calcium Phosphate Suspensions

Fabrication and characterization of bovine hydroxyapatite-gelatin-alendronate scaffold cross-linked by glutaraldehyde for bone regeneration

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