Synthesis and characterization of heteroleptic metal complexes of Isoniazid and Metformin

Abstract

Mixed ligand complexes of Metformin and Isoniazid have been synthesized and characterized by solubility studies, percentage metal analysis, UV-Vis spectroscopy, IR spectroscopy, magnetic moments and conductivity measurements. The infrared spectra revealed the coordination of the ligands to the metal ions [manganese(II), cobalt(II), nickel(II), copper(II) and zinc(II)]. Meformin coordinated as a bidentate ligand via the imine nitrogen while isoniazid coordinated through its amino nitrogen (NH) and carbonyl oxygen (C=O). The electronic 2 spectra and magnetic moments for the complexes strongly suggested a six coordinate octahedral geometry. The-1 2-1 molar conductance values of the complexes are within the range 0.45-8.72 Ω cm mol , and this confirms the non-electrolytic nature of the complexes.

Synthesis, characterization and antibacterial activity of mixed ligand complexes of Nicotinamide and 2,2′-Bipyridine

“…The syntheses and structural elucidations of several mixed ligand complexes of nicotinamide have also been reported (Sahin et al, 2016;Cakir et al, 2001;Ucar et al, 2007, Kose , 2007Al-noor, 2007, Yurdakul et al, 2014. Studies on the antimicrobial activities of the mixed ligand complexes of nicotinamide have shown that the complexes possess higher activity than the free ligands, which is in agreement with numerous reports that have shown that metal complexes of ligands or organic drugs are more active than the free ligands or drugs (Lawal et al, 2015;Akinyele et al, 2020 recorded in the 4000 -400 cm region with a Shimadzu FT-IR 8000 spectrophotometer using KBr pellets. UV-Visible spectra of the samples were measured in the range 800 -200 nm using a Shimadzu UV-Vis 1800 spectrophotometer.…”

“…The magnetic moment values as displayed in Table 4, shows that all the complexes are paramagnetic, except the Zn(II) complex which was diamagnetic. The copper(II) complex gave a value of 1.5 BM w h i c h i n d i c a t e s t h e p r e s e n c e o f antiferromagnetism , Akinyele, 2020. The magnetic susceptibility values for cobalt(II) and Ni(II) complexes supports an octahedral geometry (Cotton and Wilkinson, 1966;Lee, 1996).…”

“…Upon coordination, the electronic transitions of the complexes exhibited a positive shift toward longer wavelength with values ranging from 264-312 nm which were due to π-π* and n-π* transitions (Cakir et al, 2001;Akinyele et al, 2020), which implies a strong interaction between the ligand and the metallic ion. The visible spectra of the Co(II) complex of nicotinamide mixed with 2,2'-bipyridine showed two distinct bands at 509 4 4 nm and 666 nm which is attributed to T g→ A g 1 1 4 4 (P) and T g→ T g in an octahedral environment 1 2 (Cakir et al, 2001;Kose, 2007).…”

Water soluble Zinc(II) complexes: Geometrical, thermal, DNA/HSA/BSA binding, and cytotoxicity studies

“…It is mainly prescribed for type 2 diabetes, but it is also being used to cure polycystic ovarian syndrome, which can lead to infertility and obesity. 1 Unexpectedly, several retrospective epidemiologic studies of diabetic patients consuming metformin or phenformin over extended periods of time found that these medications decreased the risk of cardiovascular diseases and cancer. 2 Overall, metformin's antidiabetic and anticancer modes of action are quite complicated and have been extensively discussed elsewhere.…”

Isoniazid Derived Schiff Base Metal Complexes: Synthesis, Characterization, Thermal Stability, Antibacterial and Antioxidant Activity Study

“…Many investigations have demonstrated that metal complexes of isoniazid, in which isoniazid acts as a mono-, bi-, or poly-dentate ligand, not only have antibacterial activities but also have fascinating biological features. Similarly, these compounds are more effective and less harmful to the liver than isoniazid [18][19]. Multiple studies have highlighted the significance of creating new isoniazid hydrazones as possible antituberculous drugs.…”