Synthesis and characterization of hafnium oxide nanoparticles for bio-safety

Abstract

In recent years, the perspective of applying hafnium oxide (HfO 2 ) has geared up in various field of medical science such as neutron detection, bioimplants, biosensors, radiotherapy etc., The present study is to synthesis HfO 2 nanoparticles, and check its cell viability for in vivo applications. Hafnium oxide nanoparticles of different sizes (8.79, 7.16, 6.78 nm) were synthesized by varying the intervals of stirring time (6 h, 8 h, 12 h) by precipitation method. XRD pattern and Raman spectroscopy revealed that this material crystallizes in a monoclinic structure. SEM images and TEM micrographs showed that the HfO 2 NPs were spherical in shape with an average particle size of below 10 nm. The EDAX spectrum showed that the synthesized nanoparticles were HfO 2 . 3T3 fibroblast cell lines were chosen for cytotoxic study as it mimics the human cells. The aim of this study is to compare the toxicity of different sizes of HfO 2 nanoparticles on interaction with 3T3 fibroblast cell lines. From this study we could infer that smaller sized nanoparticles (6.78 and 7.17 nm) have 86% cell viability even at the concentration of 2500 g/mL.

Formation mechanism of hafnium oxide nanoparticles by a hydrothermal route

“…4,5 It oen plays an important role in the continuous down-scaling of integrated circuits since new insulating materials with a high dielectric constant are being researched to replace SiO 2 as a gate dielectric. 6,7 In terms of structural characteristics, hafnium oxide exists in three polymorphic structures, namely monoclinic (m-HfO 2 ) at low temperature, tetragonal (t-HfO 2 ) above 2050 K, and cubic (c-HfO 2 ) at around 2803 K. [8][9][10] Each structure has different applications.…”

“…Up to now, researchers have developed some synthesis approaches such as gel-sol method, 13 microemulsion processes 14 and precipitation. 10,15 However, these methods have some drawbacks, such as complicated operation, low yield and agglomerated products. In addition, all these ways only can obtain the m-HfO 2 NPs.…”

Wide‐bandgap HfO2‐V2O5 nanowires heterostructure for visible light‐driven photocatalytic degradation

“…A precipitation method was used to synthesize HfO 2 NPs. A 0.4 M (50 mL) aqueous solution of NaOH was added dropwise into a 0.1 M (50 mL) aqueous solution of HfCl 4 under continuous stirring for 6 hours to obtain white hafnium hydroxide precipitate.…”

Biological effect of zirconium dioxide-based nanoparticles

“…Previous research [16][17][18][19][20][21][22] has demonstrated the promising results for the application of nanoparticles of some metal dioxides and of solid solutions, which are composed so that they will have utility in biomedical applications. The additives, which provide certain functional properties to nanostructured materials, in particular, luminescent properties, are often used in the aforementioned nanoparticles as an admixture component.…”

“…It is worth noting that though there are several studies [16][17][18][19][20][21][22] dedicated to the biological effects of the nanoparticles, which are based on metal dioxides such as TiO 2 , HfO 2 , CeO 2 , and solid solutions containing them, there is considerably less information about the biological effect of zirconium dioxide-based nanoparticles [30][31][32]. However, since zirconium dioxide based nanopowders, solid solutions, nanocomposites and other ZrO 2 -containing nanomaterials, have become widely spread in scientific research and technological applications [33][34][35][36][37], studying their biological effect is important.…”