Synthesis and Characterization of Gold@Gold(I)−Thiomalate Core@Shell Nanoparticles

Abstract

In this paper, the synthesis of gold at gold(I)-thiolate core at shell nanoparticles is described for the first time. The chemical nature and structure of these nanoparticles were characterized by a multi-technique approach. The prepared particles consist of gold metallic cores, about 1 nm in size, surrounded by stable gold(I)-thiomalate shells (Au at Au(I)-TM). These nanoparticles could be useful in medicine due to the interesting properties that gold(I)-thiomalate has against rheumatoid arthritis. Furthermore, the described results give new insights in the synthesis and characterization of metallic and core at shell nanoparticles.

Advanced Methods of Electron Microscopy in Catalysis Research

“…In Figure 4.1, a conventional high-resolution transmission electron microscopy (HR-TEM) micrograph of a bimetallic nanoparticle 2 nm in diameter shows the interatomic distances; however, the contrast is not directly related with the different atomic positions in the bimetallic nanoparticle (Corthey et al, 2010) proposed by the theoretical model shown in Figure 4.1b. …”

“…When nanoparticles are being prepared for analysis by TEM or STEM, it is common to prepare the specimen by placing the nanoparticles on holey carbon copper grids. In some synthesis procedures, the nanoparticles are covered with a layer of organic ligands (Corthey et al, 2010); if required, this organic layer can be removed by exposing the specimen to a beam shower for a few minutes before placing it in the microscope.…”

The Development of Targeted Drug Delivery Systems for Rheumatoid Arthritis Treatment

“…Metallic nanoparticles include iron-oxide nanoparticles, silica-gold nanoshells, gold nanoparticles, and Quantum dots (cadmium, selenium, and zinc) (Riehemann et al, 2009;van Vlerken & Amiji, 2006). Although originally developed for cancer treatment, these technologies are currently being translated to rheumatoid arthritis treatment applications (Corthey et al, 2010). The use of metals can yield multifunctional nanoparticles whereby both therapeutic delivery and imaging are facilitated (Riehemann et al, 2009).…”

“…However, the synthesis of gold core-gold(I)-thiomalate nanoparticles (Au@AU(I)-TM) was recently completed. Au@Au(I)-TM bears surface carboxylate groups which may be further modified for specific drug delivery applications (Corthey et al, 2010); therefore, these nanoparticles may pave the way to a renewed interest in the use of gold in the treatment of rheumatoid arthritis.…”

A General Perspective of the Characterization and Quantification of Nanoparticles: Imaging, Spectroscopic, and Separation Techniques

“…203,204 In X-ray diffraction (XRD), 140 X-ray beams are projected over the NPs in a determined angle, called theta "θ", and the diffracted X-rays are collected in an angle of 2θ (See Table 5). XRD allows structural phase identification of the NPs cristallinity (e.g., between magnetite and maghemite NPs) 115,116 giving also the average particle size by using the Scherrer equation.…”