Synthesis and characterization of glycosylated nano particles

Lepoittevin, Bénédicte; Masson, Sébastien; Huc, Vincent; Haut, C.; Roger, Philippe

doi:10.1515/epoly.2006.6.1.415

Cited by 5 publications

(7 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Then, glycosidic molecules as maltose, maltotriose, or maltohexaose were covalently grafted onto PET fibers by amidation or reductive amination. Previously, we have already studied that these two reactions for the functionalization of polystyrene nanoparticles prepared by radical emulsion polymerization and satisfactory yields were obtained 35…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Chemical surface modification of poly(ethylene terephthalate) fibers by aminolysis and grafting of carbohydrates

Bech

Meylheuc²,

Lepoittevin

et al. 2007

J. Polym. Sci. A Polym. Chem.

Self Cite

136

126

View full text Add to dashboard Cite

PET is a semicrystalline thermoplastic polyester used in many fields. For a variety of applications, however, it is necessary to impart desired properties by introducing specific functional groups on the surface. Aminolysis of PET fibers with diamines (1,2-diaminoethane, 1,6-diaminohexane, 3,6-dioxa-1,8-diaminooctane, and 4,9-dioxa-1,12-diaminododecane) gives amino functional groups on the surface. The effects of temperature, reaction time, diamine concentration, and solvent employed for the grafting were studied. The graft yield was observed to increase with temperature, reaction time, and diamine concentration. Aminolysis affects greatly the geometry and surface morphology of PET fibers as observed by scanning electronic microscopy and atomic force microscopy in tapping mode. A decrease of fibers diameter and an increase of surface heterogeneity and roughness due to chemical degradation is observed. Amino groups on the surface were used to prepare glycosylated fibers by reductive amination or amidation with different carbohydrates as maltose, maltotriose, and maltohexaose. The study reveals that the yield is dependent on the initial amino groups' surface concentration and the molar mass of the carbohydrate. These surfaces could benefit to a wide range of applications in the biomedical field.

show abstract

Section: Resultsmentioning

confidence: 99%

“…The amount of grafted sugars was determined by phenol‐sulfuric acid colorimetric titration according to conditions previously described in literature 30, 35. This titration method is simple, rapid, sensitive, and can be applied to di, tri, and oligosaccharides.…”

Section: Resultsmentioning

confidence: 99%

Chemical surface modification of poly(ethylene terephthalate) fibers by aminolysis and grafting of carbohydrates

Bech

Meylheuc²,

Lepoittevin

et al. 2007

J. Polym. Sci. A Polym. Chem.

Self Cite

136

126

View full text Add to dashboard Cite

show abstract

“…Similar effects were used to stabilize nanoparticles. [80][81][82] A new MRI platform was developed by coupling N-acetyl-D-glucosamine and D-mannose onto magnetic nanoparticles via amidation of the amine groups in the outer shell of apoferritin containing magnetic nanoparticles. 83 Metal nanoparticle-based biomimetic strategies using conjugated carbohydrates have been reviewed as potential replacements for native biomolecules in immunoassays and catalysis applications.…”

Section: 24mentioning

confidence: 99%

Strategies in biomimetic surface engineering of nanoparticles for biomedical applications

Gong

Winnik

2012

Nanoscale

View full text Add to dashboard Cite

Engineered nanoparticles (NPs) play an increasingly important role in biomedical sciences and in nanomedicine. Yet, in spite of significant advances, it remains difficult to construct drug-loaded NPs with precisely defined therapeutic effects, in terms of release time and spatial targeting. The body is a highly complex system that imposes multiple physiological and cellular barriers to foreign objects. Upon injection in the blood stream or following oral administation, NPs have to bypass numerous barriers prior to reaching their intended target. A particularly successful design strategy consists in masking the NP to the biological environment by covering it with an outer surface mimicking the composition and functionality of the cell's external membrane. This review describes this biomimetic approach. First, we outline key features of the composition and function of the cell membrane. Then, we present recent developments in the fabrication of molecules that mimic biomolecules present on the cell membrane, such as proteins, peptides, and carbohydrates. We present effective strategies to link such bioactive molecules to the NPs surface and we highlight the power of this approach by presenting some exciting examples of biomimetically engineered NPs useful for multimodal diagnostics and for target-specific drug/gene delivery applications. Finally, critical directions for future research and applications of biomimetic NPs are suggested to the readers.

show abstract

“…To know the exact quantity of grafted sugar repeat units, PET‐poly(LAMA) surfaces were treated with trifluoroacetic acid to hydrolyze the glycosidic bonds. Then, the sugar (galactose) solubilized in water was reacted with phenol and sulfuric acid to form a colored compound according to Scheme . The sugar concentration is obtained spectrophotometrically after determination of a calibration curve.…”

Section: Resultsmentioning

confidence: 99%

Hydrophilic PET surfaces by aminolysis and glycopolymer brushes chemistry

Lepoittevin

Costa

Pardoue

et al. 2016

J. Polym. Sci. Part A: Polym. Chem.

Self Cite

View full text Add to dashboard Cite

Poly(ethylene terephthalate) (PET) is a semiaromatic thermoplastic polyester used in many fields. For specific applications, controlled of the surface wettability (hydrophily/hydrophoby) could be a great challenge. Aminolysis of PET surfaces with branched polyethylenimine gives amino functional groups on the surface with high grafting density. Then, in a second step, atom transfer radical polymerization (ATRP) initiator was grafted by reaction with 2-bromoisobutyryl bromide. Surface initiated ATRP of 2-lactobionamidoethyl methacrylate (LAMA) was performed in solution in the presence of a sacrificial initiator or an appropriate amount of Cu(II) species that act as deactivator. The efficiency of all reactions was confirmed by X-ray photoelectron spectroscopy. Wetting properties and surface energy were found to vary systematically depending to the type of functionalization and grafting. The quantity of grafted carbohydrate was determined by phenol/sulfuric acid colorimetric titration. The sugar graft density was observed to vary according to the ratio (monomer)/(free initiator). High graft density could be obtained yielding to superhydrophilic polymer brushes.

show abstract

Synthesis and characterization of glycosylated nano particles

Cited by 5 publications

References 32 publications

Chemical surface modification of poly(ethylene terephthalate) fibers by aminolysis and grafting of carbohydrates

Chemical surface modification of poly(ethylene terephthalate) fibers by aminolysis and grafting of carbohydrates

Strategies in biomimetic surface engineering of nanoparticles for biomedical applications

Hydrophilic PET surfaces by aminolysis and glycopolymer brushes chemistry

Contact Info

Product

Resources

About