Synthesis and characterization of genistein conjugated with gold nanoparticles and the study of their cytotoxic properties

Stolarczyk, Elżbieta U.; Stolarczyk, Krzysztof; Łaszcz, Marta; Kubiszewski, Marek; Maruszak, Wioleta; Olejarz, Wioletta; Bryk, Dorota

doi:10.1016/j.ejps.2016.09.019

Cited by 46 publications

(24 citation statements)

References 28 publications

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“…A shift into the nano-scale causes a significant increase in the specific grain boundary area per unit volume. This in turn results in a remarkable increase of the reactivity of the material, adsorption, anti-microbiological, and anticancer activity [ 6 , 7 , 8 , 9 , 10 ]. Nanoparticles improve therapy efficacy by transporting the drug to the drug target, thus increasing treatment safety.…”

Section: Introductionmentioning

confidence: 99%

Design and Molecular Modeling of Abiraterone-Functionalized Gold Nanoparticles

et al. 2018

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The aim of our work was the synthesis and physicochemical characterization of a unique conjugate consisting of gold nanoparticles (AuNPs) and a pharmacologically active anticancer substance abiraterone (AB). The direct coupling of AB with gold constitutes an essential feature of the unique AuNPs–AB conjugate that creates a promising platform for applications in nanomedicine. In this work, we present a multidisciplinary, basic study of the obtained AuNPs–AB conjugate. Theoretical modeling based on the density functional theory (DFT) predicted that the Aun clusters would interact with abiraterone preferably at the N-side. A sharp, intense band at 1028 cm−1 was observed in the Raman spectra of the nanoparticles. The shift of this band in comparison to AB itself agrees well with the theoretical model. AB in the nanoparticles was identified by means of electrochemistry and NMR spectroscopy. The sizes of the Au crystallites measured by XRPD were about 9 and 17 nm for the nanoparticles obtained in pH 7.4 and 3.6, respectively. The size of the particles as measured by TEM was 24 and 30 nm for the nanoparticles obtained in pH 7.4 and pH 3.6, respectively. The DLS measurements revealed stable, negatively charged nanoparticles.

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Section: Introductionmentioning

confidence: 99%

Design and Molecular Modeling of Abiraterone-Functionalized Gold Nanoparticles

et al. 2018

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“…One of the examples is the conjugate consisting of gold nanoparticles (AuNPs) and a pharmacologically active anticancer substance abiraterone (AB) or genistein (AuNPs-GE). The obtained results suggest that the complexes AuNPs with anticancer drugs can enhance their anticancer effect (32,33).…”

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confidence: 77%

Possibilities of nanodiamonds application – biological and medical aspects

Solarska-Ściuk¹,

Kleszczyńska²

2019

Acta Poloniae Pharmaceutica - Drug Research

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This topical review briefly discusses selected highlights of research on diamond nanoparticles obtained by different methods and their potential applications in biology and medicine. In recent years nanotechnology has aroused interest of a large number of scientists who endeavor to obtain nanoparticles (which differ in size and structure of surface) using different methods, in order to determine their physical, chemical and biological properties that are in relation to the methods used in the process of their production. The knowledge developed in this way will be beneficial in an attempt to use nanoparticles more reasonably in various branches of science. The distinguishing features of carbon nanoparticles are their biocompatibility, photostability and easily chemically modified surface that results in high usefulness for intracellular studies. What is more, low toxicity of nanoparticles with many cell lines is at the center of scientific interest. This, in turn, leads to a large number of biomedical applications. The property that nanodiamonds are able to penetrate cells through endocytosis, allows delivering the drug connected with nanoparticles into cancer cells. These features of nanoparticles have given many promising leads in nanooncology, in particular in drug delivery, diagnosis, imaging, and therapy. This paper presents a summary of different classes of nanodiamond particles, the ways of their uptake into cells, an overview of the possible application of nanoparticles as nanocarriers and as a clinical theranostic platform, as well as advantages and disadvantages of using nanodiamonds in biomedicine.

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“…These groups were proposed to chelate different metal ions by the following steps: (1) Adsorption onto the metal surface, (2) budding of NP, (3) aggregation, and (4) bioreduction [59]. The possible mechanism for genistein AuNPs was proposed as follows: (1) Transfer of the electron from genistein into the Au center, (2) reduction of the Au 3+ to Au 0 by genistein, and (3) further acted as a stabilizing agent to form a layer of negative ions leading to the formation of the AuNPs [71].…”

Section: Mechanisms Of Flavonoids-mediated Np Synthesismentioning

confidence: 99%

Green Synthesis of Plant-Mediated Metal Nanoparticles: The Role of Polyphenols

Ms¹,

Abbas²,

Kormin³

et al. 2019

Asian J Pharm Clin Res

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The use of metal nanoparticles (MNPs) in various fields is increasing day-by-day leading to a genuine concern about the issues related to their environmental and biological safety. The major approaches for the synthesis of NPs include physical and chemical methods which are expensive and hazardous to health in addition to being toxic to the environment. This review highlights the potential of plant extracts to carry out the synthesis of MNPs with a special emphasis on the role of flavonoids in nanosynthesis. This green and clean approach have been actively utilized in recent years as an alternative to conventional hazardous approaches. It has proved as cost-effective, non-toxic, less time and labor consuming, efficient, and eco-friendly method for the synthesis of MNPs with specific biological actions. This review also focuses on the role of polyphenols, including the flavonoids as bioreductants of metal salts for the synthesis of NPs along with their biomedical applications. Various examples of the MNPs, along with their biological actions, have also been summarized.

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Synthesis and characterization of genistein conjugated with gold nanoparticles and the study of their cytotoxic properties

Cited by 46 publications

References 28 publications

Design and Molecular Modeling of Abiraterone-Functionalized Gold Nanoparticles

Design and Molecular Modeling of Abiraterone-Functionalized Gold Nanoparticles

Possibilities of nanodiamonds application – biological and medical aspects

Green Synthesis of Plant-Mediated Metal Nanoparticles: The Role of Polyphenols

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