Synthesis and characterization of gelatin-PVP polymer composite scaffold for potential application in bone tissue engineering

Mishra, Rutusmita; Varshney, Ritu; Das, Neeladrisingha; Sircar, Debabrata; Roy, Partha

doi:10.1016/j.eurpolymj.2019.07.007

Cited by 73 publications

(49 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The TG curve of the PVP exhibited two mass losses: the first, in the range of 30 to 100 °C, with a mass variation of 8.77%, corresponding to the presence of water; the second, in the range of 357 to 480 °C, with a mass loss of 83.16%, attributed to the process of thermal polymer degradation, corroborating the literature [35,36]. For SDs with PVP, in the range of 137 to 245 °C, mass variations of 3.53% (IVS320-PVP/RE) and 1% (IVS320-PVP/KN) were found.…”

Section: Thermogravimetric Analysis (Tg)supporting

confidence: 87%

Novel Solid Dispersions of Naphthoquinone Using Different Polymers for Improvement of Antichagasic Activity

et al. 2020

View full text Add to dashboard Cite

IVS320 (3a,10b-dihydro-1H-cyclopenta[b]naphtho[2,3-d]furan-5,10-dione) is a naphthoquinone that has low solubility in aqueous medium, a physical behavior that limits its biological activities, considering that compounds from this class have several activities. In this work, solid dispersions (SDs) prepared between IVS320 and polymers hydroxypropyl methylcellulose (HPMC), polyethylene glycol (PEG), and polyvinylpyrrolidone (PVP) were developed using physical mixture (PM), kneading (KN), and rotary evaporation (RE) methods. Dispersions were investigated using Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermogravimetry (TG), powder X-ray diffraction (PXRD), and scanning electron microscopy (SEM). In addition, in vitro antiparasitic activity in Trypanosoma cruzi Y strains was evaluated. Physical-chemical characterization demonstrated the formation of SDs through the interaction of IVS320 with polymeric matrices. SDs of IVS320-polymer presented a significant potentiation of antichagasic activity, with inhibitory growth around 62% (IVS320-HPMC/RE), 55% (IVS320-PEG/RE), and 85% (IVS320-PVP/RE), while pure IVS320 showed a value of 48% for the highest concentrations evaluated (50 µg/mL).

show abstract

Section: Thermogravimetric Analysis (Tg)supporting

confidence: 87%

Novel Solid Dispersions of Naphthoquinone Using Different Polymers for Improvement of Antichagasic Activity

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The main use in research of the CAM is in the assessment of angiogenic, 21 , 41 anti-angiogenic or toxic 42 responses to drugs, 43 cells, extracellular vesicles 44 or materials, 3 biocompatibility of materials, 45 the growth or treatment of cancer 46 – 48 and xenograft application 49 – 52 for tissue growth and testing treatment modalities. Oncology research remains, to date, the most common field using the CAM assay.…”

Section: Current Common Applications Of the Cam In Researchmentioning

confidence: 99%

“…Biocompatibility of hydrophilic, porous, gelatin-polyvinylpyrrolidone (PVP) scaffolds was tested using the CAM assay by Mishra et al 45 Angiogenesis was not investigated or quantified in this study, with photographs taken at the time of material implantation and 3 days later, with no apparent indication of survival or normally developed chick numbers. It is reported that there was no effect on blood vessels compared with filter paper applied to each egg concurrently; therefore the material was deemed biocompatible due to lack of an obvious inflammatory response.…”

Section: Application Of the Cam To Test Modified Polymer Materialsmentioning

confidence: 99%

Evolving applications of the egg: chorioallantoic membrane assay andex vivoorganotypic culture of materials for bone tissue engineering

2020

View full text Add to dashboard Cite

The chick chorioallantoic membrane model has been around for over a century, applied in angiogenic, oncology, dental and xenograft research. Despite its often perceived archaic, redolent history, the chorioallantoic membrane assay offers new and exciting opportunities for material and growth factor evaluation in bone tissue engineering. Currently, superior/improved experimental methodology for the chorioallantoic membrane assay are difficult to identify, given an absence of scientific consensus in defining experimental approaches, including timing of inoculation with materials and the analysis of results. In addition, critically, regulatory and welfare issues impact upon experimental designs. Given such disparate points, this review details recent research using the ex vivo chorioallantoic membrane assay and the ex vivo organotypic culture to advance the field of bone tissue engineering, and highlights potential areas of improvement for their application based on recent developments within our group and the tissue engineering field.

show abstract

“…For example, chemical structure changes can be made in order to have a pH-responsive polymer, 9 or doping with atoms or magnetic particles to presents color effect with stimuli-responsive, 10 among other properties. 11,12 Thus, these materials are very attractive for a broad range of applications such as artificial muscles and bones, 13,14 coatings, 15 biosensors, 16 protection for ballistic impacts, 17 and many other applications. 7 Many strategies have been used in order to obtain polymers with self-healing properties, between the available possibilities, the strategy of use polymers containing chemical groups that react to form covalent bonds after damage can be highlighted.…”

Section: Introductionmentioning

confidence: 99%

Self‐healing polymer blend based on PETG and EMAA

Silva

Santos

et al. 2020

J of Applied Polymer Sci

View full text Add to dashboard Cite

In this work, novel immiscible polymer blends with remarkable self-healing properties were developed. The blends are based on poly(ethylene glycol-cocyclohexane-1,4-dimethanol terephthalate) (PETG), a nonself-healing polymer, and the ionomer sodium-neutralized poly(ethylene-co-methacrylic acid) (EMAA), with self-healing abilities. The ratios of (PETG)/ (EMAA) was varied from 0 to 100% (w/w) and mixtures were prepared using a twin-screw melt extrusion. The blend studied compositions were characterized by scanning electron microscope, differential scanning calorimetry, dynamic mechanical analysis and self-repair tests. The results revealed that blends samples were able to self-repair damages created by Vickers microhardness indentations. The self-repair is presented through video records where the establishment of scars in the damaged area can be observed. For the composition 50/50 (w/w), the whole repair was observed due the synergic effect between polymer chain mobility, new chemical interactions promoted between PETG and EMAA, thus improving its self-healing ability.

show abstract

Synthesis and characterization of gelatin-PVP polymer composite scaffold for potential application in bone tissue engineering

Cited by 73 publications

References 77 publications

Novel Solid Dispersions of Naphthoquinone Using Different Polymers for Improvement of Antichagasic Activity

Novel Solid Dispersions of Naphthoquinone Using Different Polymers for Improvement of Antichagasic Activity

Evolving applications of the egg: chorioallantoic membrane assay andex vivoorganotypic culture of materials for bone tissue engineering

Self‐healing polymer blend based on PETG and EMAA

Contact Info

Product

Resources

About