Synthesis and Characterization of Folic Acid-Conjugated Terbium Complexes as Luminescent Probes for Targeting Folate Receptor-Expressing Cells
Grace T. McMullon,
Aiarpi Ezdoglian,
Anna C. Booth
et al.
Abstract:Several conjugates between folic acid and a series of
kinetically
stable lanthanide complexes have been synthesized, using amide coupling
and azide–alkyne cycloaddition methodologies to link the metal-binding
domain to folate through a variety of spacer groups. While all these
complexes exhibit affinity for the folate receptor, it is clear that
the point of attachment to folate is essential, with linkage through
the γ-carboxylic acid giving rise to significantly enhanced
receptor affinity. All the conjugates s… Show more
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