Synthesis and characterization of electroactive and biodegradable ABA block copolymer of polylactide and aniline pentamer

Huang, Lihong; Hu, Jun; Lang, Lili; Wang, Xin; Zhang, Peibiao; Jing, Xiabin; Wang, Xianhong; Chen, Xuesi; Lelkes, Peter I.; MacDiarmid, Alan G.; Wei, Yen

doi:10.1016/j.biomaterials.2006.12.007

Cited by 259 publications

(215 citation statements)

References 41 publications

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“…The biggest limitation of conductive polymers for in vivo applications is their inherent inability to degrade, which may induce chronic inflammation and require surgical removal (Huang et al, 2007). To address the drawbacks of existing conductive polymers, attempts to blend them with suitable biodegradable polymers have been carried out.…”

Section: Conducting Polymersmentioning

confidence: 99%

Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering

Ghasemi‐Mobarakeh¹,

Prabhakaran²,

Morshed³

et al. 2011

J Tissue Eng Regen Med

586

383

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Among the numerous attempts to integrate tissue engineering concepts into strategies to repair nearly all parts of the body, neuronal repair stands out. This is partially due to the complexity of the nervous anatomical system, its functioning and the inefficiency of conventional repair approaches, which are based on single components of either biomaterials or cells alone. Electrical stimulation has been shown to enhance the nerve regeneration process and this consequently makes the use of electrically conductive polymers very attractive for the construction of scaffolds for nerve tissue engineering. In this review, by taking into consideration the electrical properties of nerve cells and the effect of electrical stimulation on nerve cells, we discuss the most commonly utilized conductive polymers, polypyrrole (PPy) and polyaniline (PANI), along with their design and modifications, thus making them suitable scaffolds for nerve tissue engineering. Other electrospun, composite, conductive scaffolds, such as PANI/gelatin and PPy/poly(ε-caprolactone), with or without electrical stimulation, are also discussed. Different procedures of electrical stimulation which have been used in tissue engineering, with examples on their specific applications in tissue engineering, are also discussed.

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Section: Conducting Polymersmentioning

confidence: 99%

Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering

Ghasemi‐Mobarakeh¹,

Prabhakaran²,

Morshed³

et al. 2011

J Tissue Eng Regen Med

586

383

View full text Add to dashboard Cite

show abstract

“…Certain inorganic/ceramic materials such as hydroxyapatite (HAP) or calcium phosphates, having good osteoconductivity and being studied for mineralized tissue engineering, are also limited due to poor processability into highly porous structures and brittleness. In contrast, polymers have great design flexibility because the composition and structure can be tailored to the specific needs, and therefore have been extensively studied in various tissue engineering applications, including bone tissue engineering [4,5,8,9].…”

Section: Introductionmentioning

confidence: 99%

Biomimetic materials for tissue engineering

Peter

2008

Advanced Drug Delivery Reviews

1,180

812

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Tissue engineering and regenerative medicine is an exciting research area that aims at regenerative alternatives to harvested tissues for transplantation. Biomaterials play a pivotal role as scaffolds to provide three-dimensional templates and synthetic extracellular-matrix environments for tissue regeneration. It is often beneficial for the scaffolds to mimic certain advantageous characteristics of the natural extracellular matrix, or developmental or would healing programs. This article reviews current biomimetic materials approaches in tissue engineering. These include synthesis to achieve certain compositions or properties similar to those of the extracellular matrix, novel processing technologies to achieve structural features mimicking the extracellular matrix on various levels, approaches to emulate cell-extracellular matrix interactions, and biologic delivery strategies to recapitulate a signaling cascade or developmental/would-healing program. The article also provides examples of enhanced cellular/tissue functions and regenerative outcomes, demonstrating the excitement and significance of the biomimetic materials for tissue engineering and regeneration.

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“…Pioneering studies have demonstrated the efficiency of using ECPs for electrical interfacing with neural cells and tissues [18][19][20][21][22][23][24][25][26] .…”

mentioning

confidence: 99%

Large enhancement in neurite outgrowth on a cell membrane-mimicking conducting polymer

et al. 2014

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Although electrically stimulated neurite outgrowth on bioelectronic devices is a promising means of nerve regeneration, immunogenic scar formation can insulate electrodes from targeted cells and tissues, thereby reducing the lifetime of the device. Ideally, an electrode material capable of electrically interfacing with neurons selectively and efficiently would be integrated without being recognized by the immune system and minimize its response. Here we develop a cell membrane-mimicking conducting polymer possessing several attractive features. This polymer displays high resistance towards nonspecific enzyme/cell binding and recognizes targeted cells specifically to allow intimate electrical communication over long periods of time. Its low electrical impedance relays electrical signals efficiently. This material is capable to integrate biochemical and electrical stimulation to promote neural cellular behaviour. Neurite outgrowth is enhanced greatly on this new conducting polymer; in addition, electrically stimulated secretion of proteins from primary Schwann cells can also occur on it.

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Synthesis and characterization of electroactive and biodegradable ABA block copolymer of polylactide and aniline pentamer

Cited by 259 publications

References 41 publications

Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering

Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering

Biomimetic materials for tissue engineering

Large enhancement in neurite outgrowth on a cell membrane-mimicking conducting polymer

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