Synthesis and characterization of double molecular imprinted nanoparticles and investigation to adsorption of respiratory drugs

Demir, Esra Feyzioğlu; Akgöl, Sinan

doi:10.1080/25740881.2021.1991949

Cited by 3 publications

(2 citation statements)

References 40 publications

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“…Polymer based nanocarriers have been extensively employed in delivery of imaging agents and therapeutically active molecules [87]. It has been demonstrated that the MIP-based drug delivery systems enhanced drug efficiency with desired controlled release and decreased side effects due to better drug encapsulation [23,88,89]. Surface properties of the inorganic material have an important role in determining the overall biocompatibility; therefore, surface modifications can deliver MIP-based core-shell systems suitable for in vivo studies.…”

Section: Drug Deliverymentioning

confidence: 99%

Molecularly Imprinted Polymer-Coated Inorganic Nanoparticles: Fabrication and Biomedical Applications

et al. 2022

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Molecularly imprinted polymers (MIPs) continue to gain increasing attention as functional materials due to their unique characteristics such as higher stability, simple preparation, robustness, better binding capacity, and low cost. In particular, MIP-coated inorganic nanoparticles have emerged as a promising platform for various biomedical applications ranging from drug delivery to bioimaging. The integration of MIPs with inorganic nanomaterials such as silica (SiO2), iron oxide (Fe3O4), gold (Au), silver (Ag), and quantum dots (QDs) combines several attributes from both components to yield highly multifunctional materials. These materials with a multicomponent hierarchical structure composed of an inorganic core and an imprinted polymer shell exhibit enhanced properties and new functionalities. This review aims to provide a general overview of key recent advances in the fabrication of MIPs-coated inorganic nanoparticles and highlight their biomedical applications, including drug delivery, biosensor, bioimaging, and bioseparation.

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Section: Drug Deliverymentioning

confidence: 99%

Molecularly Imprinted Polymer-Coated Inorganic Nanoparticles: Fabrication and Biomedical Applications

et al. 2022

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“…Molecularly imprinted polymers (MIPs) represent a well-established class of materials with a rich historical background and a diverse array of applications. , In the realm of chemical analysis, MIPs have the potential to substitute biogenic materials like antibodies, providing the necessary selectivity for analytical methods. − Beyond their various applications, the preparation of MIPs for analysis demands meticulous consideration of specific factors that play a critical role in influencing the overall efficiency of the imprinting process . MIPs exhibit distinctive selectivity for a predefined analyte or compounds sharing similar structures, featuring detection regions that prevent unintended binding. − Their versatility finds application across various domains, including industry, medicine, agriculture, and the environment . The attractiveness of MIPs lies in their cost-effectiveness, simplicity, ease of production, physical durability, stability, resistance to temperature and pressure, applicability to numerous target analytes, and high affinity for these targets .…”

Section: Introductionmentioning

confidence: 99%

Selective Extraction and Quantification of Hemoglobin Based on a Novel Molecularly Imprinted Nanopolymeric Structure of Poly(acrylamide-vinyl imidazole)

Şarkaya,

Özçelik,

Yaşar

et al. 2024

ACS Omega

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Imbalances in hemoglobin (Hb) levels can lead to conditions such as anemia or polycythemia, emphasizing the importance of precise Hb extraction from blood. To address this, a novel synthetic imprinted polymer was meticulously developed for capturing and separating Hb. Poly(acrylamide-vinylimidazole) nanopolymer (poly(AAm-VIM)) was synthesized using acrylamide and vinyl imidazole as functional monomers through surfactant-free emulsion polymerization. Characterization using FTIR, particle size, zeta potential, and SEM ensured the polymer's structure. The Hb-imprinted nanopolymer (Hbpoly(AAm-VIM)) demonstrated notable specificity, with a calculated Hb-specific adsorption value (Q max ) of 3.7377 mg/g in a medium containing 2.5 mg/mL Hb. The molecularly imprinted polymer (MIP) exhibited approximately 5 times higher Hb adsorption than the nonimprinted polymer (NIP). Under the same conditions, the imprinted nanopolymer displayed 2.39 and 2.17 times greater selectivity for Hb over competing proteins such as bovine serum albumin (BSA) and lysozyme (Lys), respectively. Also, SDS-PAGE analysis results confirmed the purification of Hb by the molecularly imprinted nanopolymer. These results underscore the heightened specificity and efficacy of the molecularly imprinted nanopolymer in selectively targeting Hb atoms among other proteins. Incorporating such polymers is justified by their notable affinity, cost-effectiveness, and facile production. This research contributes valuable insights into optimizing synthetic imprinted polymers for efficient Hb extraction, with potential in medical diagnostics and treatment applications.

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Investigation of controlled salmeterol xinafoate and fluticasone propionate release from double molecular imprinted nanoparticles

Feyzioğlu-Demir,

Akgöl

2024

Polym. Bull.

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Salmeterol xinafoate (SAM) and fluticasone propionate (FLU) are one of the drug combinations used together in the treatment of lung diseases such as asthma and chronic obstructive pulmonary disease (COPD). The aim of this study is to investigate the usability of novel dual molecular imprinted nanoparticles (poly(2-hydroxyethyl methacrylate-N-methacryloyl-(L)-alanine-N-methacryloyl-(L)-histidine) [p(HEMA-MAAL-MAH)], abbr. DMIPNPs) as a controlled drug release systems. In this study, SAM and FLU drugs were chosen as model drugs because they are used in the treatment of these diseases. DMIPNPs were prepared by surfactant-free emulsion polymerization method and characterized by scanning electron microscopy (SEM) and fourier transform infrared spectrometer (FTIR). In in vitro drug release experiments, drug release conditions were optimized. SAM and FLU release from DMIPNPs experiments were also performed in the simulated lung fluid (SLF). The amount of released SAM and FLU were found as 4.79 and 5.68 mg/g in the SLF medium at the end of 48 h, respectively. The release kinetics of SAM and FLU from DMIPNPs were calculated in the SLF medium. The release of SAM and FLU was determined to be compatible with the Higuchi release models. According to these results, these DMIPNPs, dual-template molecular imprinted nanoparticles with dual monomers, are promising materials that can be used in the controlled release of two different drugs. Graphical abstract

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Synthesis and characterization of double molecular imprinted nanoparticles and investigation to adsorption of respiratory drugs

Cited by 3 publications

References 40 publications

Molecularly Imprinted Polymer-Coated Inorganic Nanoparticles: Fabrication and Biomedical Applications

Molecularly Imprinted Polymer-Coated Inorganic Nanoparticles: Fabrication and Biomedical Applications

Selective Extraction and Quantification of Hemoglobin Based on a Novel Molecularly Imprinted Nanopolymeric Structure of Poly(acrylamide-vinyl imidazole)

Investigation of controlled salmeterol xinafoate and fluticasone propionate release from double molecular imprinted nanoparticles

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