Synthesis and characterization of dipicolinate sensitized LaF3:Tb3+ nanoparticles and their interaction with bovine serum albumin

Jing, Kui; Guo, Xingjia; Diao, Xin; Wu, Qiong; Jiang, Yuchun; Sun, Ye; Pan, Xintong; Zhou, Nannan; Zhu, Yanjun

doi:10.1016/j.jlumin.2014.08.061

Cited by 9 publications

(2 citation statements)

References 32 publications

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“…Evidently, the K q value was greater than that of the diffusion controlled limit of 2.0 9 10 10 L mol -1 s -1 . This result denotes that the quenching of BSA was purely due to the static collision process and also confirms that there is a possibility of specific binding of 5FU-NPs in BSA, and these drug-conjugated nanoparticles can be transported by the carrier protein inside the body (Jing et al 2015).…”

Section: Uv-visible Absorption Studiessupporting

confidence: 65%

Synthesis of 5-Fluorouracil conjugated LaF3:Tb3+/PEG-COOH nanoparticles and its studies on the interaction with bovine serum albumin: spectroscopic approach

et al. 2015

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The luminescent lanthanide-doped nanoparticles have gathered considerable attention in many fields especially in biomedicine. In this work, the lanthanum fluoride-doped terbium nanoparticles (LaF 3 :Tb 3? NPs) via simple chemical precipitation method has been synthesized and functionalized with polyethylene glycol. The size and the shape of the nanoparticles are confirmed using X-ray diffraction and transmission electron microscopy. The conjugation of 5-Fluorouracil (5-FU) and thus synthesized nanoparticles (NPs) were confirmed using various spectroscopic methods such as UVVisible spectroscopy, fluorescence steady state, and excited state spectroscopy studies. The enhancement in fluorescence emission (k = 543 nm) of drug-conjugated nanoparticles confirms the Vander Waals force of attraction due to F-F bonding between the drug and the nanoparticles. Further, the effects of 5FU-NPs in carrier protein were investigated using bovine serum albumin as a protein model. The 5FU-LaF 3 :Tb 3? nanoparticles binding is illustrated with binding constant and number of binding sites. The structural change of bovine serum albumin has been studied using circular dichroism and Fourier transform infrared spectroscopy analysis. Graphical AbstractKeywords Lanthanum fluoride Á 5-Fluorouracil Á Serum albumin Á Fluorescence quenching Á Vander Waal force of attraction

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Section: Uv-visible Absorption Studiessupporting

confidence: 65%

Synthesis of 5-Fluorouracil conjugated LaF3:Tb3+/PEG-COOH nanoparticles and its studies on the interaction with bovine serum albumin: spectroscopic approach

et al. 2015

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“…The red shifts of λ max for Tyr and Trp residues indicate that the polarity in the micro‐regions around Tyr and Trp residues increased. Thus, Tyr and Trp residues were placed in a less hydrophobic environment, namely, more exposed to aqueous solvent during the interaction of ALBC with HSA .…”

Section: Resultsmentioning

confidence: 99%

Comparative studies on the interactions of baicalein and Al(III)–baicalein complex with human serum albumin

Wang

et al. 2015

Luminescence

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A new potential drug aluminum(III)-baicalein complex (ALBC) was synthesized and characterized. The binding mechanisms of baicalein (BC) and ALBC to human serum albumin (HSA) under simulative physiological conditions were investigated, in order to understand the pharmacokinetics of BC and ALBC. Fluorescence spectroscopy results suggested that the binding level of BC is higher than that of ALBC. Results of UV-vis, synchronous fluorescence, 3D fluorescence, circular dichroism and Fourier transform infrared spectroscopic analyses consistently demonstrated that the conformation of HSA was altered when bound to BC or ALBC. The distance between HSA as a donor and BC (or ALBC) as an acceptor was determined via fluorescence resonance energy transfer. The results of competitive experiments and molecular docking studies indicated that BC was located in site I (subdomain IIA) on HSA and that ALBC was bound to HSA mainly within site II (subdomain IIIA).

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Dual-emission LaF3:Tb@DPA-Eu nanoparticles as a ratiometric fluorescence probe for the detection of marbofloxacin

Duan

Wang

et al. 2021

Microchemical Journal

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Synthesis and characterization of dipicolinate sensitized LaF3:Tb3+ nanoparticles and their interaction with bovine serum albumin

Cited by 9 publications

References 32 publications

Synthesis of 5-Fluorouracil conjugated LaF3:Tb3+/PEG-COOH nanoparticles and its studies on the interaction with bovine serum albumin: spectroscopic approach

Synthesis of 5-Fluorouracil conjugated LaF3:Tb3+/PEG-COOH nanoparticles and its studies on the interaction with bovine serum albumin: spectroscopic approach

Comparative studies on the interactions of baicalein and Al(III)–baicalein complex with human serum albumin

Dual-emission LaF3:Tb@DPA-Eu nanoparticles as a ratiometric fluorescence probe for the detection of marbofloxacin

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