Synthesis and characterization of CuO nanoparticles stabilized by quercetin and its application for anti-breast cancer activity

Abstract

The main idea in this research used quercetin (QT) as a stabilizing agent to prepare CuO nanoparticle (NPs). QT is a pigment which exists from plants, fruits, and in some medicines. It contains numerous hydroxyl groups, works as a complexing agent and a self-assembly agent. The prepared CuO-NPs were characterized by Fourier transformed infrared (FT-IR), X-ray diffraction (XRD), scanning and transmission electron microscopy (SEM and TEM), and energy-dispersive X-ray analysis (EDX). The structure investigation confirm that the CuO-NPs were polycrystalline nature having a monoclinic crystalline form and showed (111̅ ) and (111) preferential orientations. The estimated particle sizes by XRD, TEM, and SEM ranged from 12.03 to 15.3 nm. Surface analysis displayed that homogeneously distributed CuO-NPs with a spherical shape. On the other hand, synthesized CuO-NPs were tested for anticancer activity on the human breast. The infected cell (MCF-7) uses MTT (3-(4,5-dimethyl-2-triazolyl)-2,5-diphenyl-2tetrazolium bromide) test. The inferred CuO-NPs clarify high anticancer cytotoxicity of the (MCF-7) with an IC50 μM value of 57.6 and 42.8 µg/mL for 24 and 72 h respectively.

Antibacterial Activity of Green Synthesized Copper Oxide Nanoparticles

“…The results of S. epidermidis showed that the inhibition zone diameter values were 16.4 mm at a concentration of 100 μg/mL, 15.2 mm at 75 μg/mL, and 13.5 mm at 50 μg/mL, while at the concentration of 25 μg/mL, the diameter recorded was 11.6 mm. The results of the present study agree with those of Alishah et al, where CuO NPs were found to have an inhibitory effect on S. epidermidis [9]. As for P. aeruginosa, the diameter of the zone of inhibition showed values of 17 mm at 100 μg/mL, 16.4mm at 75 μg/mL, 15.2 mm at 50 μg/mL, and 13.26 mm at 25 μg/mL.…”

Study the Effect of Copper Oxide Nanorods Enhanced by Silver Nanoparticles on the Highly Sensitive Gas Sensor

“…The peaks positions and relative intensities of the diffraction peaks of (32.5⁰, 35.5⁰, and 38.9⁰) correspond to the lattice plane of (110), ( 111) and (002) respectively reflections, in agreement with JCPDS data for CuO (JCPDS: card no. 48-1548) [27][28][29]. Therefore, the result here confirmed the evaporated films are CuO.…”

New Construction of Functionalized CuO/Al2O3 Nanocomposite-Based Polymeric Sensor for Potentiometric Estimation of Naltrexone Hydrochloride in Commercial Formulations

“…Currently, several reports are focused on metal oxides, including aluminium oxide (Al 2 O 3 ), copper oxide (CuO), nickel oxide (NiO), etc. Moreover, more attention has been focused on the perspective of copper oxide in various aspects such as antibacterial agents [12], catalysis [13], food packaging [14], sensors [15] and medicine [16]. Recently, there has been a growing awareness of the development of aluminium oxide nanoparticles (Al 2 O 3 NPs) which have a high specific surface area with extraordinary optical, catalytic, thermodynamic stability properties for progressive engineering and industrial applications [17][18][19].…”