Synthesis and characterization of Cu(II), Co(II) and Ni(II) complexes of a number of sulfadrug azodyes and their application for wastewater treatment

El-Baradie, Kamal Y.; El-Sharkawy, Rehab G.; El‐Ghamry, Hoda A.; Sakai, Ken

doi:10.1016/j.saa.2013.09.070

Cited by 48 publications

(31 citation statements)

References 37 publications

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“…With respect to complexes 2 and 5 , the change in this band is attributed to its involvement in hydrogen bond formation with the adjacent NH group. The non‐ligand bands appearing in the complex spectra within 572–514 and 460–441 cm −1 ranges can be attributed to M─O and M─N stretching vibrations, respectively …”

Section: Resultsmentioning

confidence: 99%

Synthesis, structural characterization and DNA binding affinity of new bioactive nano‐sized transition metal complexes with sulfathiazole azo dye for therapeutic applications

Saad

El‐Ghamry

Kassem

2019

Applied Organom Chemis

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The azo dye ligand 4‐(5‐chloro‐2‐hydroxyphenylazo)‐N‐thiazol‐2‐ylbenzenesulfonamide (H2L) formed by the coupling reaction of sulfathiazole and p‐chlorophenol was synthesized and characterized using elemental analysis and Fourier transform infrared (FT‐IR) as well as UV–visible spectra. Nano‐sized divalent Cu, Co, Ni, Mn and Zn complexes of the synthesized azo dye ligand were prepared and investigated using various spectroscopic and analytical techniques. Elemental and thermal analyses indicated the formation of the Cu(II), Ni(II) and Mn(II) complexes in a molar ratio of 1:2 (L:M) while Co(II) and Zn(II) complexes exhibited a 1:1 (M:L) ratio. FT‐IR spectral studies confirmed the coordination of the ligand to the metal ions through the phenolic hydroxyl oxygen, azo nitrogen, sulfonamide oxygen and/or thiazole nitrogen. The geometric arrangements around the central metal ions were investigated applying UV–visible and electron spin resonance spectra, thermogravimetric analysis and molar conductance measurements. X‐ray diffraction patterns revealed crystalline nature of H2L and amorphous nature of all synthesized complexes. Transmission electron microscopy images confirmed nano‐sized particles and their homogeneous distribution over the complex surface. Antibacterial, antifungal and antitumour activities of the investigated complexes were screened compared with familiar standard drugs to confirm their potential therapeutic applications. The Cu(II) complex showed IC50 of 3.47 μg ml−1 (5.53 μM) against hepatocellular carcinoma cells, which means that it is a more potent anticancer drug compared with the standard cisplatin (IC50 = 3.67 μg ml−1 (12.23 μM)). Furthermore, the Co(II), Ni(II), Cu(II) and Zn(II) complexes displayed IC50 greater than that of an applied standard anticancer agent (5‐flurouracil) towards breast carcinoma cells. Hence, these complexes can be considered as promising anticancer drugs. The mode of binding of the complexes with salmon serum DNA was determined through electronic absorption titration and viscosity studies.

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Section: Resultsmentioning

confidence: 99%

Synthesis, structural characterization and DNA binding affinity of new bioactive nano‐sized transition metal complexes with sulfathiazole azo dye for therapeutic applications

Saad

El‐Ghamry

Kassem

2019

Applied Organom Chemis

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“…All the chemicals used in the synthesis of the compounds in the present study were of pure grade supplied by Sigma‐Aldrich in Japan as well as the solvents which were used for the spectral measurements. The instruments used for structure characterization are previously reported .…”

Section: Methodsmentioning

confidence: 99%

“…The azo dye ligand, H 2 L (Fig. ), was prepared by the coupling of sulfadiazine diazonium salt with 8‐hydroxy‐5‐nitroquinoline according to the previously reported method .…”

Section: Methodsmentioning

confidence: 99%

Nitroxoline Azo Dye Complexes as Effective Heterogeneous Catalysts for Color Removal and Degradation of Some Organic Textile Dyes

El-Wakiel

El‐Ghamry

2017

Int. J. Chem. Kinet.

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A new azo dye ligand of sulfadiazine with 5‐nitro‐8‐hydroxyquinoline (H2L) and its Cu(II), Mn(II), Co(II), and Ni(II) complexes have been synthesized and characterized using CHN, 1H NMR, EI‐mass, inductive coupled plasma, molar conductance, IR, thermogravimetric analysis, magnetic moment measurements, and UV–vis spectra. On the basis of spectral studies and analytical data, the azo dye acts as a monobasic bidentate ligand coordinating to the metal ions via deprotonated OH and azo nitrogen atom. The spectral data showed that the synthesized complexes have octahedral geometry. The application of the obtained chelates in the oxidative decomposition of three different textile dyes (i.e., AB92, AB40, and AB129) in the presence of H2O2 as an oxidant has been studied. The obtained results indicated that the reactivity of catalysts toward the decolorization of AB40 showed the following order: Cu complex > Ni complex > Co complex > Mn complex; the reactions obey the first‐order reaction mechanism, and the rate constants were determined.

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“…Structurally modified sulphonamides were found to be potential inhibitors of histone deacetylase and to cease tumour cell growth in vivo in animal cultures . The prominent mechanism behind the anti‐cancer effect of sulphonamide includes cell cycle perturbation in the G1 phase; CA and angiogenesis inhibition are known . Sulphonamide derivatives inhibit CA through coordination of their SO 2 NH anion with the Zn 2+ cation of the enzyme, leading to a reduction in

{HCO}_{3}^{-}

synthesis in the transition state required for CA to function …”

Section: Introductionmentioning

confidence: 99%

Antimicrobial sulphonamide azo dyes

Gaffer

2019

Coloration Technology

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Sulphonamide motifs are widely found in many drug candidates with relevant biological activity. Moreover, sulphonamide azo dyes are interesting candidates for synthetic chemists because such dyes provide access to a broad range of functional group transformations. Therefore, many synthetic procedures for the preparation of sulphonamide azo dyes have been developed in recent decades, and the search for rapid and efficient protocols is ongoing. The current article aims to review recent trends in the synthesis of sulphonamide azo dyes and their applications as high‐performance colorants with antimicrobial activity. For convenience, the diverse uses of sulphonamide azo dyes are discussed from the perspective of the application type rather than the structural class.

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Synthesis and characterization of Cu(II), Co(II) and Ni(II) complexes of a number of sulfadrug azodyes and their application for wastewater treatment

Cited by 48 publications

References 37 publications

Synthesis, structural characterization and DNA binding affinity of new bioactive nano‐sized transition metal complexes with sulfathiazole azo dye for therapeutic applications

Synthesis, structural characterization and DNA binding affinity of new bioactive nano‐sized transition metal complexes with sulfathiazole azo dye for therapeutic applications

Nitroxoline Azo Dye Complexes as Effective Heterogeneous Catalysts for Color Removal and Degradation of Some Organic Textile Dyes

Antimicrobial sulphonamide azo dyes

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