Synthesis and Characterization of Colistin Loaded Nanoparticles Used to Combat Multi-drug Resistant Microorganisms

Ichim, Daniela Luminița; Duceac, Letiția Doina; Constantin, Marcu; Iordache, Alin Constantin; Ciomaga, Irina Mihaela; Luca, Alina Costina; Goroftei, Elena Roxana Bogdan; Mitrea, Geta; Damir, Daniela

doi:10.37358/rc.19.10.7635

Cited by 5 publications

(3 citation statements)

References 5 publications

(2 reference statements)

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“…Dentro do biofilme pode existir uma única espécie de bactérias ou um consórcio de multiespécies microbianas (Haussler & Fuqua, 2013;Kumar et al, 2017). As infecções nosocomiais causadas por esses patógenos MDR representam um problema global, tornando-se nos últimos anos uma das principais causas de morte (Ichim et al, 2019). Assim, grupos de pesquisas buscam estratégias terapêuticas eficazes para o tratamento de infecções causadas por esses patógenos, podendo se basear na utilização da nanotecnologia farmacêutica através do uso dos lipossomas.…”

Section: Problemática Das Infecções Causadas Por Enterobactériasunclassified

Vantagens da utilização de antibióticos encapsulados em lipossomas para o combate de infecções causadas por enterobactérias

Silva¹,

Souza

Macêdo

et al. 2021

RSD

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Introdução: O tratamento de doenças causadas por enterobactérias é um desafio cada vez maior. Esse problema resulta na ineficiência dos antibióticos combaterem os patógenos ou estimularem a fagocitose de células do sistema reticuloendotelial, principalmente contra bactérias que se instalam e se multiplicam no interior de células fagocíticas. Alguns antibióticos são ineficazes em adentrar as células ou tem sua capacidade reduzida pela membrana plasmática. Assim, a comunidade científica reúne esforços buscando novas alternativas terapêuticas que ultrapassem essas limitações. Os lipossomas são nanocarreadores lipídicos capazes de encapsular antibióticos, visando o aumento na especificidade da entrega, a concentração de compostos entregues ao local, manter a concentração plasmática dos fármacos e proteger os princípios ativos. Assim, o objetivo dessa revisão foi descrever as principais propriedades lipossomais, enfatizando as vantagens de utilizar essas vesículas lipídicas para administração de antibióticos frente a infecções causadas por enterobactérias. Metodologia: Trata-se de uma revisão bibliográfica através de buscas nas bases eletrônicas nacionais e internacionais selecionando artigos de 2007 a 2020 utilizando os descritores: Bactérias gram-negativas, Resistência bacteriana, Antimicrobianos e Nanotecnologia. Resultados: Lipossomas catiônicos e furtivos constituídos principalmente por colesterol, PEG, fosfatidilcolina e carboximetilquitosana encapsulando fármacos como amoxicilina, ciprofloxacina, cloxacilina, vancomicina, azitromicina, amoxicilina, cefepime, gentamicina e cefotaxime demonstraram atividade antibacteriana. Lipossomas encapsulando fármacos como cloranfenicol, azitromicina, gentamicina e polimixina B apresentaram maior eficiência antibiofilme frente a enterobactérias quando comparados aos fármacos não encapsulado. Conclusão: Os resultados mostraram que os lipossomas apresentam potencial terapêutico significativo para o tratamento de infecções causadas por enterobactérias.

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Section: Problemática Das Infecções Causadas Por Enterobactériasunclassified

Vantagens da utilização de antibióticos encapsulados em lipossomas para o combate de infecções causadas por enterobactérias

Silva¹,

Souza

Macêdo

et al. 2021

RSD

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“…In addition, post-COVID syndrome has caused difficulties in completing tasks and maintaining work schedules due to long-term symptoms, in some cases leading to temporary measures to adapt the workplace to allow workers to recover [41]. Another stress factor for healthcare workers has been the fear of becoming contaminated by the patients they care for and subsequently developing a variety of infectious pathologies, either as a result of decreased resistance due to overwork or as a complication of pre-existing chronic conditions [42][43][44][45].…”

Section: Introductionmentioning

confidence: 99%

Stress Factors for the Paediatric and Adult Palliative Care Multidisciplinary Team and Workplace Wellbeing Solutions

Popa,

Mîndru,

Hizanu (Dumitrache)

et al. 2024

Healthcare

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Background: Palliative care is a challenging specialty, especially when it comes to caring for children with serious life-limiting conditions and supporting their families. Workers face significant challenges and experience major impacts on their wellbeing. We conducted a qualitative study to understand the sources of stress in the palliative care team, their work expectations, and how they can cope with the demands. Methods: We used an online questionnaire about the causes of stress, the impact of the COVID-19 pandemic and the ways in which support is needed in the workplace. Results: Of the 56 palliative care professionals who participated in the survey, 57.1% considered the main causes of stress to be high workload, difficult emotional burdens (55.4%) affecting their outlook on life (61.2%), the death of patients (46.4%), and communication with patients’ families (26.8%). The COVID-19 pandemic increased stress levels for the majority of respondents (89.3%). The need for specialised training (53.6%), support groups, psychological counselling and adapted organisational policies was highlighted. Conclusions: The study demonstrates the importance of understanding the needs of both paediatric and adult palliative care staff in order to provide optimal care and support their balance in this demanding area of the healthcare system.

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“…Their capacity to incorporate various active molecules offers the possibility of enhancing the bactericidal and bacteriostatic efficacy of the antibiotic, limiting, at the same time, the adverse effect [18][19][20]. In order to limit ceftriaxone resistance, drug carriers based on chitosan nanoparticles may increase the therapeutic efficiency of the antibiotic by prolonging its release as well as minimizing its side effects [21][22][23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Third-Generation Cephalosporin-Loaded Chitosan Used to Limit Microorganisms Resistance

et al. 2020

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From their discovery, antibiotics have significantly improved clinical treatments of infections, thus leading to diminishing morbidity and mortality in critical care patients, as well as surgical, transplant and other types of medical procedures. In contemporary medicine, a significant debate regarding the development of multi-drug resistance involves all types of pathogens, especially in acute care hospitals due to suboptimal or inappropriate therapy. The possibility of nanotechnology using nanoparticles as matrices to encapsulate a lot of active molecules should increase drug efficacy, limit adverse effects and be an alternative helping to combat antibiotic resistance. The major aim of this study was to obtain and to analyze physico-chemical features of chitosan used as a drug-delivery system in order to stop the antibiotic resistance of different pathogens. It is well known that World Health Organization stated that multidrug resistance is one of the most important health threats worldwide. In last few years, nano-medicine emerged as an improved therapy to combat antibiotic-resistant infections agents. This work relies on enhancement of the antimicrobial efficiency of ceftriaxone against gram(+) and gram(−) bacteria by antibiotic encapsulation into chitosan nanoparticles. Physicochemical features of ceftriaxone-loaded polymer nanoparticles were investigated by particle size distribution and zeta potential, Fourier-transform infrared spectroscopy (FTIR), Thermal Gravimetric Analysis (TG/TGA), Scanning Electron Microscopy (SEM) characteristics techniques. The obtained results revealed an average particle size of 250 nm and a zeta potential value of 38.5 mV. The release profile indicates an incipient drug deliverance of almost 15%, after 2 h of approximately 83%, followed by a slowed drug release up to 24 h. Characteristics peaks of chitosan were confirmed by FTIR spectra indicating a similar structure in the case of ceftriaxone-loaded chitosan nanoparticles. A good encapsulation of the antibiotic into chitosan nanoparticles was also provided by thermo-gravimetric analysis. Morphological characteristics shown by SEM micrographs exhibit spherical nanoparticles of 30–250 nm in size with agglomerated architectures. Chitosan, a natural polymer which is used to load different drugs, provides sustained and prolonged release of antibiotics at a specific target by possessing antimicrobial activity against gram(+) and gram(−) bacteria. In this research, ceftriaxone-loaded chitosan nanoparticles were investigated as a carrier in antibiotic delivery.

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Synthesis and Characterization of Colistin Loaded Nanoparticles Used to Combat Multi-drug Resistant Microorganisms

Cited by 5 publications

References 5 publications

Vantagens da utilização de antibióticos encapsulados em lipossomas para o combate de infecções causadas por enterobactérias

Vantagens da utilização de antibióticos encapsulados em lipossomas para o combate de infecções causadas por enterobactérias

Stress Factors for the Paediatric and Adult Palliative Care Multidisciplinary Team and Workplace Wellbeing Solutions

Third-Generation Cephalosporin-Loaded Chitosan Used to Limit Microorganisms Resistance

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