Synthesis and Characterization of Chitosan/Hydroxyapatite Biocomposites Obtained by Reaction of Precipitation

Abstract

There is a growing need for new biomaterials that can gain predictable and controlled tissue response, this is, that as bone graft substitutes should initiate new bone formation, after which they should get reabsorbed and replaced by bone tissue. This combination aims to improve the mechanical properties, degradation rates and absorption rates of biocompatibility and biodegradability. The aim of this study was to propose a synthetic route in which the HA was obtained by reaction of precipitation directly on evaluating the influence of chitosan biopolymer in the middle of precipitation in the characteristics of hydroxyapatite obtained. XRD analysis revealed the presence of HA phase with low crystallinity. In the FTIR analysis identified the characteristic bands of hydroxyapatite, as well as bands that characterize an interaction between chitosan and hydroxyapatite, as the band around 1050cm-1. SEM analysis of the biocomposites chitosan/HA, showed a dispersion of HA particles in chitosan, revealing a homogenous material and microporous.

In Situ Precipitation of Cluster and Acicular Hydroxyapatite onto Porous Poly(γ-benzyl-l-glutamate) Microcarriers for Bone Tissue Engineering

“…55 The in situ precipitation method based on specific templates was regarded as an extension of the method. 56 In situ precipitation depends on the nucleation−aggregation−growth mechanism. Ca and P sources are anchored on the template by chemical or physical action to achieve local saturation of ion concentration.…”

“…Among them, the precipitation method has the advantages of low cost, simple process requirement, low reaction temperature, and high controllability of HA morphology . The in situ precipitation method based on specific templates was regarded as an extension of the method . In situ precipitation depends on the nucleation–aggregation–growth mechanism.…”