Synthesis and characterization of chitosan-coated magnetite nanoparticles and their application in curcumin drug delivery

Pham, Xuan Nui; Nguyen, Tan Phuoc; Pham, Tuyet Nhung; Tran, Thi Thuy Nga; Tran, Thi Van Thi

doi:10.1088/2043-6262/7/4/045010

Cited by 131 publications

(75 citation statements)

References 34 publications

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“…In Raman spectroscopy, the minor peak at 600 cm −1 was corresponding to the A1 g mode of magnetite where peaks at 220 and 280 for Eg mode (Fig. 7a), these similar peaks were already reported (Justin et al 2017;Mitchell et al 2015;Panta and Bergmann 2015;Pham et al 2016). There is a shift in Raman spectrum due to chitosan coating (Fig.…”

Section: Characterization Of Spions and Chitosan-coated Spionssupporting

confidence: 80%

Utilization of chitosan-coated superparamagnetic iron oxide nanoparticles for chromium removal

et al. 2018

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Superparamagnetic iron oxide nanoparticles (SPIONs) have been widely used for their versatility, while it is coated with a biopolymer like chitosan that adds attraction and also increases its applications. In this study, SPION was synthesized by chemical co-precipitation method, characterized using various analytical techniques like UV-Vis, FTIR, SEM, EDX, TEM, AFM, XRD, zeta potential and Raman spectroscopy analysis. Chitosan was coated onto the SPIONs and used for water treatment to remove chromium (450 ppm concentration). Chitosan-coated SPIONs were found to remove about 80% of chromium. Freundlich model was found to be fitting better for the current study.

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Section: Characterization Of Spions and Chitosan-coated Spionssupporting

confidence: 80%

Utilization of chitosan-coated superparamagnetic iron oxide nanoparticles for chromium removal

et al. 2018

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“…The pH of the reaction medium then rose to above 10 by adding 2 M of NaOH solution dropwise. The higher pH (10)(11)(12)(13)(14) ensures the complete precipitation of iron salts as well as decreases the size of nanoparticles. The temperature was then raised to 70 °C with continuous stirring and purging N 2 gas for 5 h. The precipitate obtained was then filtered, washed with acetone and double-distilled water until the pH comes to neutral, and then dried for 5-6 h at 70 °C in a hot air oven.…”

Section: Synthesis Of Spionsmentioning

confidence: 99%

“…SPIONs find applications in the fields of chemical catalysis, magnetic fluids, magnetic seals, data storage and various bio-applications like clinical diagnosis and therapy (such as MRI and MFH), biological labels, magnetic bio-separation and targeted drug delivery [4][5][6][7][8][9]. The SPIONs give the freedom to control the morphology, shape and size of the nanoparticles during the synthesis process, which can be used further in different applications [10][11][12][13]. The surface of iron oxide nanoparticles can be modified or coated as per need using various polymers, surfactants and inorganic materials like silica [14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Inhibitive effect of super paramagnetic iron oxide nanoparticles on the alkaline hydrolysis of procaine

2019

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The Super Paramagnetic Iron Oxide Nanoparticles (SPIONs) can bind drugs and act as drug-carriers. The magnetically active SPIONs can be used to deliver the drugs to the target through magnetic fields. The objective of the present work has been undertaken to study the stability, and binding behaviour of procaine with SPIONs and surfactant-coated SPIONs. Procaine is among the ester drugs and hydrolyses in the alkaline medium. The influence of SPIONs and surfactant-coated SPIONs on the rate of hydrolysis of procaine in alkaline medium may help to define the behaviour of the drug in the presence of these nanoparticles. The kinetic studies of procaine hydrolysis in the presence of SPIONs and surfactant-coated SPIONs were carried out spectrophotometrically. The concentrations of OH − ions were taken in excess over [procaine] to keep the reaction conditions under pseudo-first-order. The presence of SPIONs and the SPIONs coated with cetyltrimethylammonium bromide; CTABr and sodium dodecylsulphate; SDS surfactants displayed an inhibitive effect on the rate of hydrolysis of procaine. The synthesised nanoparticles were characterised using X-ray diffraction (XRD), scanning electron microscopy (SEM), vibrating sample magnetometer (VSM), transmission electron microscopy (TEM) and Fourier transform infrared spectroscopy (FTIR). The k ψ-[surfactant] profile in the presence of SPIONs was discussed using the pseudophase model in which the reactants are considered to be distributed in the aqueous and micellar media. The rate constant for the procaine hydrolysis and the binding constants of procaine with coated and non-coated SPIONs have been calculated by analysing the data for the variation in the rate constant with the change in [surfactant], [SPIONs] and [surfactant-coated SPIONs].

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“…Furthermore, NPs covering with biocompatible biopolymers such as chitosan, a cationic biopolymer at lower pHs, has attracted particular attention since it presents low toxicity, mucoadhesive properties, a flexible structure, and hydroxyl and amino groups with strongly affinity with water [19,[30][31][32]. Chitosan (CS), has been extensively researched in recent years as a primary material in the formation of carriers for therapeutic proteins and as non-viral gene-carrying vehicles [33][34][35], being therefore used in several pharmaceutical applications [33].…”

Section: Introductionmentioning

confidence: 99%

Biocompatible superparamagnetic nanoparticles with ibuprofen as potential drug carriers

et al. 2020

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This article describes the synthesis, characterization, in vitro cytotoxic and genotoxicity evaluation of chitosan-iron oxide nanoparticles (Fe 3 O 4 -CS) as vehicles for ibuprofen (IBU) molecule. Magnetite (Fe 3 O 4 ) nanoparticles were synthesized by co-precipitation of iron salts and coated with chitosan, leading to the formation of Fe 3 O 4 -CS hybrid nanoparticles, and then IBU was adsorbed on the surface of the modified nanoparticles. The physicochemical, morphological, and magnetic properties of the nanoparticles were determined by X-ray powder diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy and SQUID magnetic measurements. The nanoparticles have shown stability in aqueous medium presenting an average hydrodynamic size of 36 ± 9 nm for Fe 3 O 4 -CS, and 132 ± 1 nm for Fe 3 O 4 -CS-IBU. The cytotoxicity of nanoparticles using the cell viability of the blood mononuclear cell fraction and the analysis of gene expression of the repair genes hMSH2, hMSH6 and NF-kB were performed to evaluate their applicability as drug carriers. The results showed that Fe 3 O 4 -CS nanoparticles are suitable candidates as magnetic vehicles for ibuprofen in biomedical applications. Graphic abstract

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Synthesis and characterization of chitosan-coated magnetite nanoparticles and their application in curcumin drug delivery

Cited by 131 publications

References 34 publications

Utilization of chitosan-coated superparamagnetic iron oxide nanoparticles for chromium removal

Utilization of chitosan-coated superparamagnetic iron oxide nanoparticles for chromium removal

Inhibitive effect of super paramagnetic iron oxide nanoparticles on the alkaline hydrolysis of procaine

Biocompatible superparamagnetic nanoparticles with ibuprofen as potential drug carriers

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