Synthesis and characterization of chitosan/carbon quantum dots/Fe2O3 nanocomposite comprising curcumin for targeted drug delivery in breast cancer therapy

Targeted Anticancer Drug Delivery Using Chitosan, Carbon Quantum Dots, and Aptamers to Deliver Ganoderic Acid and 5‐Fluorouracil

“…Their results showed that the nanocomposites synthesized based on chitosan, carbon, and Fe2O3 have a spherical surface and an average size of 227.2 nm. Also, the synthesized nanocomposites had a positive zeta potential, indicating the manufactured drug's complete stability [39] . A novel pH‐sensitive nanocarrier based on a combination of chitosan (Cs), agarose (AG), and graphite carbon nitride (g‐C3N4) curcumin was created in another work by Rajabzadeh‐Khosroshahi et al.…”

“…Also, the synthesized nanocomposites had a positive zeta potential, indicating the manufactured drug's complete stability. [39] A novel pH-sensitive nanocarrier based on a combination of chitosan (Cs), agarose (AG), and graphite carbon nitride (g-C3N4) curcumin was created in another work by Rajabzadeh-Khosroshahi et al to supply curcumin. The study's findings demonstrated that XRD, FT-IR, Zeta/DLS, and FESEM characterization analyses verified the chemical bonds between CS, AG, and g-C3N4 and the interactions with the drug.…”

Recent advances in biomedical applications of carbon and graphene quantum dots: A review

“…CQDs and GQDs are basically bright photoluminescent quasispherical nanoparticles of around 10 nm size having graphitic sp 2 or sp 3 carbon hybridization. These are noncytotoxic under dark conditions, making them suitable for various therapeutic applications such as gene delivery, biosensing, drug delivery, bioimaging, cell labeling, and so on (Azam et al, 2021;Chung et al, 2021;Devi et al, 2022;Kaur et al, 2022;Tajik et al, 2020;Zhou et al, 2020;Zirak Hassan Kiadeh et al, 2022;Zoghi et al, 2023). Interestingly, their photoluminescence regions are very broad ranging from the near ultraviolet to near-infrared.…”

“…Zoghi et al fabricated a nanocomposite from chitosan, Fe 2 O 3 along with CQDs and encapsulated the hydrophobic anticancer drug, curcumin. In vitro studies in MCF-7 cancer cells by MTT assay and flow cytometry indicated significant cytotoxicity and the Korsmeyer-Peppas kinetic model was found to fit predominantly among the various drug release models(Zoghi et al, 2023).Khoshnood et al synthesized nitrogen-containing CQDs with ultrahigh photoluminescence quantum yield and conjugated them with folic acid and doxorubicin. They studied the bioimaging and cytotoxic properties of the conjugates both in vitro and in vivo and reported that the conjugate has higher toxicity in cancer cells in vitro with higher internalization in vivo, than the free drug(Khoshnood et al, 2023).…”

Cutting-edge approaches for targeted drug delivery in breast cancer: beyond conventional therapies

“…Recent research has focused on dual pH-responsive micelles for co-delivery of axitinib and paclitaxel, enhancing their anticancer efficacy against breast cancer. 90 …”