Synthesis and Characterization of Calcium Phosphate Ceramic/(Poly(vinyl alcohol)–Polycaprolactone) Bilayer Nanocomposites-A Bone Tissue Regeneration Scaffold

Maheshwari, Subramanian Uma; Govindan, K.; Raja, M. Manivel; Raja, Atul Kumar; Pravin, M B S; Kumar, Sourav

doi:10.1166/jnn.2018.14259

Cited by 7 publications

(3 citation statements)

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“…PVA has two diffraction peaks at 2θ ~19.2° and 20.2° [ 26 , 27 ], whereas PVP has two broad humps at approximately 2 θ ~11.2° and 21.2° [ 28 ]. As the PVA blended with the PVP, the positions of the diffraction peaks are changed due to the formation of intermolecular hydrogen bonding between the PVA and PVP polymers [ 29 ]. The diffraction patterns of the doped blends have a similar trend as they are loaded with up to 11% TPAI or 6% THAI without any characteristic peaks from the TPAI or THAI salt, indicating a complete dissociation of the salt in the blend matrix.…”

Section: Resultsmentioning

confidence: 99%

Structural, Optical, and Electrical Parameters of Doped PVA/PVP Blend with TPAI or THAI Salt

El-Naggar,

Brnawi,

Kamal

et al. 2023

Polymers

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The 70% polyvinyl alcohol/30% polyvinyl pyrrolidone (PVA/PVP) polymer blends, with different weight ratios of tetrapropylammonium iodide (TPAI) or tetrahexylammonium iodide (THAI) salt, were prepared using dimethyl sulfoxide (DMSO) as a solvent. The X-ray diffraction technique was used to trace the crystalline nature of the formed blends. The SEM and EDS techniques were applied to figure out the morphology of the blends. The variation in the FTIR vibrational bands was used to investigate the chemical composition and the effect of different salt doping on the functional groups of the host blend. The influence of the salt type (TPAI or THAI) and its ratio on the linear and nonlinear optical parameters for the doped blends were investigated in detail. Absorbance and reflectance are highly enhanced in the UV region reaching a maximum for the blend with 24% TPAI or THAI; so, it can be employed as shielding materials for UVA and UVB types. The direct (5.1 eV) and indirect (4.8 eV) optical bandgaps were reduced continuously to (3.52, 3.63 eV) and (3.45, 3.51 eV) while increasing the content of TPAI or THAI, respectively. The blend doped with 24% wt TPAI exhibited the highest refractive index (around 3.5 in 400–800 nm). The DC conductivity is affected by the content and type of salt, its dispersion, and blend-salt interaction. The activation energies of different blends were obtained by applying the Arrhenius formula.

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Section: Resultsmentioning

confidence: 99%

Structural, Optical, and Electrical Parameters of Doped PVA/PVP Blend with TPAI or THAI Salt

El-Naggar,

Brnawi,

Kamal

et al. 2023

Polymers

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“…The effects of tricalcium phosphate (TCP) on nanocomposites’ shape, crystalline structure, functional groups, and thermal behavior were studied. SEM was used to examine ultrathin cross-sections of the nanocomposites, which revealed that all except the polycaprolactone (PCL)-TCP fibers had an average fiber diameter (AFD) of about 100 nm [ 52 ]. For bone tissue engineering, metallic implants such as magnesium-based alloy foams may be utilized as a potential scaffold material due to their mechanical strength.…”

Section: Nanocomposite Ceramic’s Potential Role In Bone Regenerationmentioning

confidence: 99%

Recent Developments in Polymer Nanocomposites for Bone Regeneration

Abbas

Alqahtani

Alhifzi

2023

IJMS

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Most people who suffer acute injuries in accidents have fractured bones. Many of the basic processes that take place during embryonic skeletal development are replicated throughout the regeneration process that occurs during this time. Bruises and bone fractures, for example, serve as excellent examples. It almost always results in a successful recovery and restoration of the structural integrity and strength of the broken bone. After a fracture, the body begins to regenerate bone. Bone formation is a complex physiological process that requires meticulous planning and execution. A normal healing procedure for a fracture might reveal how the bone is constantly rebuilding as an adult. Bone regeneration is becoming more dependent on polymer nanocomposites, which are composites made up of a polymer matrix and a nanomaterial. This study will review polymer nanocomposites that are employed in bone regeneration to stimulate bone regeneration. As a result, we will introduce the role of bone regeneration nanocomposite scaffolds, and the nanocomposite ceramics and biomaterials that play a role in bone regeneration. Aside from that, recent advances in polymer nanocomposites might be used in a variety of industrial processes to help people with bone defects overcome their challenges will be discussed.

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“…The bioactivity of the scaffolds is increased with combination of the polymers with ceramics such as hydroxyapatite (HA) 7 . Ceramics are other important factors in the preparation of bone scaffolds 24 . In the present study, HA that is one of the main inorganic components of natural bone was selected as the ceramic phase of PCL/PHBV blending.…”

Section: Introductionmentioning

confidence: 99%

Design and fabrication of bone tissue scaffolds based on PCL/PHBV containing hydroxyapatite nanoparticles: dual‐leaching technique

Nahanmoghadam

Asemani

Goodarzi

et al. 2020

J Biomedical Materials Res

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Scaffolds are the important part of the tissue‐engineering field that are made from different biomaterials using various techniques. In this study, new scaffold based on polycaprolactone (PCL) and poly (hydroxybutyrate‐co‐hydroxyvalerate) (PHBV) containing hydroxyapatite nanopraticles (n‐HA) were fabricated using the dual‐leaching technique (DLT). Morphology, porosity, degradation rate, Fourier transfer infrared ray (FTIR) spectra, surface, and mechanical properties as well as capacity of cell binding and cell proliferation on the constructed scaffolds were evaluated. FTIR analysis showed that n‐HA particles have some interest interactions with polymeric chains. The best 3D‐structure was seen in PCL70PHBV30 scaffold using the scanning electron microscopy (SEM) and its structure improved in the presence of 3, 5 wt% of n‐HA. Results of energy dispersive x‐ray analysis (EDXA, map of Ca) showed that the nanoparticles have the uniform distribution within the fabricated scaffolds. Porosity analysis showed that the particulate salt leaching technique is a successful approach to building a 3D structure. Increasing of PHBV content and n‐HA up to 3 and 5 wt% in the PCL matrix led to increase porosity in all samples. Mechanical properties analysis showed that values of compression modulus and strength are decreased with addition of PHBV and HA nanoparticles. These results were directly in line with the results of morphology and porosity. Cell culture experiments demonstrated that the PCL/PHBV/nHA nanocomposite scaffold has a better tendency of proliferation to cells than that of the pure PCL/PHBV scaffold. All of these results suggest promising potentials of the developed PCL/PHBV/nHA scaffolds in this study desire for bone tissue engineering.

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Synthesis and Characterization of Calcium Phosphate Ceramic/(Poly(vinyl alcohol)–Polycaprolactone) Bilayer Nanocomposites-A Bone Tissue Regeneration Scaffold

Cited by 7 publications

References 0 publications

Structural, Optical, and Electrical Parameters of Doped PVA/PVP Blend with TPAI or THAI Salt

Structural, Optical, and Electrical Parameters of Doped PVA/PVP Blend with TPAI or THAI Salt

Recent Developments in Polymer Nanocomposites for Bone Regeneration

Design and fabrication of bone tissue scaffolds based on PCL/PHBV containing hydroxyapatite nanoparticles: dual‐leaching technique

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