Synthesis and characterization of bisphenol-A imprinted polymer as a selective recognition receptor

Cela-Pérez, M.C.; Castro-López, Mar; Lasagabáster-Latorre, A.; López‐Vilariño, J.M.; González-Rodríguez, M. Victoria; Barral, L.

doi:10.1016/j.aca.2011.09.002

Cited by 45 publications

(36 citation statements)

References 38 publications

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“…To obtain higher recovery for the four CTKs, the effect of sample flow rate on the MIP extraction was investigated in the range from 0.05 to 0.2 mL/min. The obtained results showed that the recoveries of four CTKs decreased with increasing sample flow rate, resulting from binding equilibrium and mass transfer kinetics [41,42]. When the flow rate is too high, the binding interactions between the four CTKs and binding sites on the MIP are not enough to equilibrate, so that the analytes cannot be effectively adsorbed by MIP in monolith.…”

Section: Optimization Of Sample Flow Ratementioning

confidence: 93%

Monolithic molecularly imprinted solid-phase extraction for the selective determination of trace cytokinins in plant samples with liquid chromatography–electrospray tandem mass spectrometry

Ruan

Sheng-hua

et al. 2012

Anal Bioanal Chem

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Cytokinins (CTKs) are a class of growth-regulating hormones involved in various physiological and developmental processes. More novel analytical methods for the accurate identification and quantitative determination of trace CTKs in plants have been desired to better elucidate the roles of CTKs. In this work, a novel method based on monolithic molecularly imprinted solid-phase extraction followed by liquid chromatography-electrospray tandem mass spectrometry (mMI-SPE-LC-MS/MS) was developed for accurate determination of four CTKs in plant samples. The molecularly imprinted polymer monolith was prepared by using kinetin as the template in syringes and exhibited specific recognition ability for the four CTKs in comparison with that of non-imprinted polymer monolith. Several factors affecting the extraction performance of mMI-SPE, including the pH of loading sample solution, the nature and volume of elution solvent, the flow rate of sample loading, and sample volume, were investigated, respectively. Under the optimized conditions, the proposed mMI-SPE-LC-MS/MS method was successfully applied in the selective extraction and determination of four CTKs in plant tissues, and it offers detection limits (S/N = 3) of 104, 113, 130, and 89 pg/mL and mean recoveries of 85.9%, 79.3%, 73.5%, and 70.1% for kinetin, kinetin glucoside, trans-zeatin, and meta-topolin (mT), respectively, with the corresponding RSDs less than 15%.

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Section: Optimization Of Sample Flow Ratementioning

confidence: 93%

Monolithic molecularly imprinted solid-phase extraction for the selective determination of trace cytokinins in plant samples with liquid chromatography–electrospray tandem mass spectrometry

Ruan

Sheng-hua

et al. 2012

Anal Bioanal Chem

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“…Phenol has only one hydroxyl group, therefore, it can be retained in a binding site only by one hydrogen bond. In contrast to phenol, MIPs with higher imprinting factors have been prepared for 2,4-dichlorophenol (2.1) [9], 2,4-dinitrophenol (2.2) [10], bisphenol A [14], hydroquinone (2.2) [12]. These species used as templates have more specific shape and at least two functional groups available for bonding (e.g., two –NO 2 and one –OH in dinitrophenol).…”

Section: Resultsmentioning

confidence: 99%

“…Many MIPs have been synthesized for a range of phenols: chlorophenols [4,8,9], nitrophenols [5,10,11], dixydroxyphenols [6,12], nonylphenol [13], and bisphenol A [14], though only few of them target phenol and simple alkylphenols. MIPs for phenol have been prepared by non-covalent imprinting approach in the form of crushed monolith [15], a recognition layer immobilized on silica particles [16], as a membrane [17].…”

Section: Introductionmentioning

confidence: 99%

Development of Molecularly Imprinted Polymer in Porous Film Format for Binding of Phenol and Alkylphenols from Water

Gryshchenko

Bottaro

2014

IJMS

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Molecularly imprinted polymers (MIPs) were fabricated on glass slides with a “sandwich” technique giving ~20 μm thick films. Methanol/water as a solvent, and polyethyleneglycol and polyvinylacetate as solvent modifiers, were used to give a porous morphology, which was studied with scanning electron microscopy and gravimetric analysis. Various MIPs were synthesized through non-covalent imprinting with phenol as the template; itaconic acid, 4-vinylpyridine, and styrene as monomers; ethylene glycol dimethacrylate, triethylene glycol dimethacrylate, and pentaerythritol triacrylate (PETA) as cross-linkers. Binding and imprinting properties of the MIPs were evaluated based on phenol adsorption isotherms. Since phenol has only one weakly acidic hydroxyl group and lacks unique structural characteristics necessary for binding specificity, the preparation of selective MIPs was challenging. The recognition of phenol via hydrogen bonding is suppressed in water, while hydrophobic interactions, though promoted, are not specific enough for highly-selective phenol recognition. Nevertheless, the styrene-PETA MIP gave modest imprinting effects, which were higher at lower concentrations (Imprinting Factor (IF) = 1.16 at 0.5 mg·L−1). The isotherm was of a Freundlich type over 0.1–40 mg·L−1 and there was broad cross-reactivity towards other structurally similar phenols. This shows that phenol MIPs or simple adsorbents can be developed based on styrene for hydrophobic binding, and PETA to form a tighter, hydrophilic network.

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“…Each group of experiments was carried out five times in parallel. Moreover, related descriptions on the adsorption isotherms and binding kinetics fitting analyses were given in Supporting information, i.e., Langmuir, Freundlich, Scatchard, Langmuir-Freundlich models [27,28], and pseudo-first-order, pseudo-second-order, Elovich and intraparticle diffusion models [29,30].…”

Section: Static and Kinetic Adsorption Experimentsmentioning

confidence: 99%

Thermosensitive molecularly imprinted polymers on porous carriers: Preparation, characterization and properties as novel adsorbents for bisphenol A

Dong

Xiong

et al. 2014

Talanta

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a b s t r a c tThermosensitive molecularly imprinted polymers (T-MIPs) on porous carriers were prepared via the synergy of dual functional monomers of 4-vinylpyridine (VP) and N-isopropylacrylamide (NIPAM), for selective recognition and controlled adsorption and release of bisphenol A (BPA) by the temperature regulation. The porous polymer supporter was synthesized by multistep swelling of polystyrene and then both the NIPAM with temperature responsiveness and the basic monomers of VP were grafted on them in a simple way. The resultant T-MIPs showed high binding capacity, fast kinetics, and the adsorption processes were found to follow Langmuir-Freundlich isotherm and pseudo-second-order kinetic models. The adsorption capacity increased slightly along with the rise of temperature (such as 20 1C) under lower critical solution temperature (LCST, 33 1C) and decreased fast above LCST (such as 50 1C). Subsequently, the T-MIPs were employed as novel adsorbents for selective solid-phase extraction (SPE) of BPA from seawater and yogurt samples. Satisfying recoveries in the range of 94.83-98.47% were obtained with the precision of 3.21% at ambient temperature (20 1C). Through 6 adsorption-desorption cycles, the reusable T-MIPs exhibited a good recoverability with the relative standard error within 9.8%. The smart T-MIPs provided great potentials for selective identification, adsorption/release and removal of BPA by simple stimuli responsive regulation.

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Synthesis and characterization of bisphenol-A imprinted polymer as a selective recognition receptor

Cited by 45 publications

References 38 publications

Monolithic molecularly imprinted solid-phase extraction for the selective determination of trace cytokinins in plant samples with liquid chromatography–electrospray tandem mass spectrometry

Monolithic molecularly imprinted solid-phase extraction for the selective determination of trace cytokinins in plant samples with liquid chromatography–electrospray tandem mass spectrometry

Development of Molecularly Imprinted Polymer in Porous Film Format for Binding of Phenol and Alkylphenols from Water

Thermosensitive molecularly imprinted polymers on porous carriers: Preparation, characterization and properties as novel adsorbents for bisphenol A

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