Synthesis and characterization of biodegradable poly(3-hydroxybutyrate) and poly(ethylene glycol) multiblock copolymers

Zhao, Qiang; Cheng, Guoxiang; Li, Haiming; Ma, Xiaolu; Zhang, Liguang

doi:10.1016/j.polymer.2005.08.014

Cited by 41 publications

(26 citation statements)

References 33 publications

(37 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Estudos para a formação de oligômeros de PHB para a síntese de copolímeros vêm sendo realizados com sucesso [9] . Exemplos bem sucedidos utilizando o PHB como constituinte são os copolímeros biodegradáveis multiblocos de PHB/PEG [10] . Diversos estudos sobre as propriedades de blendas PHB/PCL vêm sendo realizados para possibilitar sua aplicação.…”

Section: Resultsunclassified

Síntese e caracterização do copolímero poli(3-hidroxibutirato-co-ε-caprolactona) a partir de poli (3-hidroxibutirato) e poli(ε-caprolactona)

et al. 2010

View full text Add to dashboard Cite

Resumo: O copolímero poli(3-hidroxibutirato-co-ε-caprolactona) foi sintetizado por transesterificação, a partir dos homopolímeros PHB e PCL, usando acetilacetonato de zircônio (IV), como catalisador, nas concentrações de 20, 50 e 80% de PHB em massa. Os copolímeros foram caracterizados por GPC, métodos espectroscópicos (RMN-1 H, RMN-13 C e IV-FT) e métodos térmicos (TG e DSC). A rota de síntese utilizada mostrou-se eficaz na síntese dos copolímeros P(HB-co-CL), os quais mostraram diminuição das cadeias poliméricas, apresentando Mw inferior a 24.000 Daltons. Todos os copolímeros obtidos são termicamente mais estáveis que o PHB e com menor cristalinidade que os homopolímeros de partida. Esses materiais são bons candidatos para utilização como biomateriais em matrizes para liberação controlada de fármacos ou mesmo como compatibilizante em blendas PHB/PCL. Palavras-chave: Biopolímeros, PHB, PCL, copolímero P(HB-co-CL).Synthesis and Characterization of the Copolymer Poly(3-Poly(3-Hydroxybutyrate)-co-ε-Caprolactone) from Poly(3-Hydroxybutyrate) and Poly(ε-Caprolactone) Abstract: In the present work, the copolymer poly(3-hydroxybutyrate-co-ε-caprolactone), P(HB-co-CL), was prepared by transesterification reaction from PHB and PCL. Zirconium (IV) acetylacetonate was used as catalyst and the copolymers were obtained in a wide range of compositions of PHB/PCL (20/80, 50/50, 80/20). These copolymers were characterized by GPC, FT-IR, 1 H-NMR, 13 C-NMR, TG, and DSC. The copolymers had weight average molecular weight less than 24.000 Daltons. All the systems were thermally more stable than PHB, showing lower crystallinity than the homopolymers. These materials are good candidates to be used as biomaterials, in drug release matrices, or even as PHB/PCL blends compatibilizers. Keywords: Biopolymers, PHB, PCL, P(HB-co-CL) copolymer. IntroduçãoDentre os vários materiais biodegradáveis, podemos citar a família dos poli(hidroxialcanoatos), PHAs, poliésteres provenientes de fontes renováveis, produzidos por uma ampla variedade de microrganismos como forma de reserva intracelular de carbono e energia [1] . Dentro da família dos PHAs destaca-se o poli(3-hidroxibutirato), PHB, que apresenta propriedades similares às do polipropileno [2] , sendo, porém, mais duro e quebradiço [3] . Tem crescido significativamente o interesse no estudo do PHB pelo seu variado potencial de aplicação, como em membranas [4] e na preparação de copolímeros, usando o hidroxivalerato, ou de compósitos com hidroxiapatita como forma de torná-lo menos quebradiço, no sentido de aumentar sua empregabilidade.O PHB é um poliéster termoplástico de origem microbiana sintetizado por diversas bactérias (por exemplo, Alcaligenes eutrophus e Rhodospirillum rubrum) que ocorrem naturalmente no solo. Esse é, em muitos casos, o polímero que mais se aproxima de um eco-material ideal: é obtido de fontes renováveis, é facilmente biodegradado em solos de compostagem, é biorreabsorvível e biocompatível (pode ser usado em implantes médicos ou como substrato para crescimento celular) ...

show abstract

Section: Resultsunclassified

Síntese e caracterização do copolímero poli(3-hidroxibutirato-co-ε-caprolactona) a partir de poli (3-hidroxibutirato) e poli(ε-caprolactona)

et al. 2010

View full text Add to dashboard Cite

show abstract

“…PHB and PEG segments formed separate crystalline phases with a lower crystallinity and a lower melting point than those of their corresponding pre-polymers, and a glass transition temperature between two pre-polymers. Young's modulus and the stress at break of the copolymers increased with increasing PHB segment length or PEG segment length, whereas the strain at break increased with increasing PEG segment length or decreasing PHB segment length [85,86]. When fabricated into an electrospun fibrous scaffold, it can be coated with calcium minerals by simple incubation in simulated body fluid, showing a potential application for bone regeneration [87].…”

Section: Acyl Chloridementioning

confidence: 99%

Synthetic routes to degradable copolymers deriving from the biosynthesized polyhydroxyalkanoates: A mini review

Ke¹,

Zhang²,

Ramakrishna³

et al. 2016

Express Polym. Lett.

View full text Add to dashboard Cite

Abstract.Polyhydroxyalkanoates are a family of natural polyesters being produced as intracellular carbon and energy reserves by a wide variety of microorganisms. They have developed rapidly in both research and development efforts globally in the last 15 years. Till now, over 100 different types of PHAs have been successfully biosynthesized using both genetic engineering and fermentation techniques. Their unique biodegradable, biocompatible and thermoplastic characteristics make PHAs promising candidates for the commodity and biomedical applications. This review focused on the chemical synthesis of the derivatives of the biosynthesized PHAs.

show abstract

“…46 In this study, a series of linear poly(ether urethane)s was achieved via controlling the stoichiometric amount at 1 : 1 molar ratio of aliphatic diol to PEG-diisocyanate. It was previously reported that excess HDI (HDI : diol = 1.3 : 1) might lead to a cross-linked product.…”

Section: Synthesis and Characterizationmentioning

confidence: 99%

Precise control of drug release from dually responsive poly(ether urethane) nanoparticles

Wang

et al. 2013

RSC Adv.

View full text Add to dashboard Cite

A series of linear poly(ether urethane)s was synthesized based on alternating PEG-diisocyanate of different molecular weight and N-methyldiethanolamine containing ternary amino moieties. The molecular structures of the obtained copolymers were confirmed with nuclear magnetic resonance, Fourier transform infrared spectroscopy and gel permeation chromatography. In aqueous solution, the amphiphilic copolymers could self-assemble into nanoparticles, which showed temperature and pH dual-responsive character. The stimuli-responsive behavior was characterized by light transmission, dynamic light scattering, nuclear magnetic resonance, and transmission electron microscopy. The phase transition temperature (T p ) of the nanoparticles could be modulated by changing the molecular weight of the PEG segments. The encapsulation and release of doxorubicin (DOX) were investigated using the obtained polymeric nanoparticles as carriers. The in vitro experimental results showed that DOX release from the nanoparticles was significantly accelerated when it was conducted at a higher temperature and lower pH value. Importantly, only when the ambient temperature was higher than the corresponding T p , the drug release could be remarkably enhanced by the pH decrease. The system showed a temperaturetriggered pH-dependent drug release. Cell viability and microscopic observation of liver cells (HepG2 cells) treated with the DOX-loaded polymeric nanoparticles demonstrated that the therapeutic activity and the DOX distribution could be precisely controlled by the novel dual-responsive system.

show abstract

Synthesis and characterization of biodegradable poly(3-hydroxybutyrate) and poly(ethylene glycol) multiblock copolymers

Cited by 41 publications

References 33 publications

Síntese e caracterização do copolímero poli(3-hidroxibutirato-co-ε-caprolactona) a partir de poli (3-hidroxibutirato) e poli(ε-caprolactona)

Síntese e caracterização do copolímero poli(3-hidroxibutirato-co-ε-caprolactona) a partir de poli (3-hidroxibutirato) e poli(ε-caprolactona)

Synthetic routes to degradable copolymers deriving from the biosynthesized polyhydroxyalkanoates: A mini review

Precise control of drug release from dually responsive poly(ether urethane) nanoparticles

Contact Info

Product

Resources

About